Study of inhomogeneous tissue equivalent water thickness correction method in proton therapy

Xie Zhao; Zou Lian; Hou Qing; Zheng Xia

doi:10.7498/aps.62.068701

Abstract

The inhomogeneous tissue equivalent water thickness correction method is an important part of research in proton radiotherapy. In this paper, we simulate the transport processes of a high-energy proton beam being injected into the water and other materials using Monte-Carlo multi-particle transport code Fluka, and according to the energy deposition distribution we obtain the depth of the Bragg peak when the protons are injected into different materials. Then we fit an analytic formula (R = αE0p) to the relationship between initial proton energy and the depth of the proton Bragg peak in different materials. It is found that for the different energies of proton beam being injected into non-uniform organization, the difference between the Bragg peak depth from fitting and the depth of the proton beam Bragg peaks from Fluka program is less than 1 mm. If we can establish a database about the relationship of Bragg peak ratio between medium and water, with electron density, then the equivalent water thickness correction method will be able to applied to the dose calculation of for homogeneous medium in proton therapy.

Keywords:

Authors and contacts

1.
Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Joint Laboratory for Medical Physics, Radiation Oncology Center, Chengdu 610072, China;
2.
Key Laboratory for Radiation Physics and Technology of Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, China;
3.
Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Emergency Department, Chengdu 610072, China

References

[1]	Wilson B R 1946 Radiology 47 487
[2]	Tobias C A, Aanger H O, Lawrence J H 1952 Am. J. Roetgenl. 67 1
[3]	Alfredo F, Paola R S, Alberto F, Johannes R 2011 Fluka: a multi-particle transport code. (Italian National Institute for Nuclear Physics (INFN) and European Organization for Nuclear Research (CERN))
[4]	I Ferrari R A, Mairani A, Paganetti H，Parodi K, Sala P 2011 Phys. Med. Biol. 56 4001
[5]	Ju Z P, Cao W F, Liu X W 2009 Acta Phys. Sin. 58 174 (in Chinese) [鞠志萍, 曹午飞, 刘小伟 2009 物理学报 58 174]
[6]	Ju Z P, Cao W F, Liu X W 2010 Acta Phys. Sin. 59 199 (in Chinese) [鞠志萍, 曹午飞，刘小伟 2010物理学报 59 199]
[7]	Wang Y G, Luo Z M 2000 Acta Phys. Sin. 49 1639 (in Chinese) [王营冠, 罗正明 2000物理学报 49 1639]
[8]	Bortfeld T 1997 Med. Phys. 24 2024

Cited By

[1]	Wilson B R 1946 Radiology 47 487
[2]	Tobias C A, Aanger H O, Lawrence J H 1952 Am. J. Roetgenl. 67 1
[3]	Alfredo F, Paola R S, Alberto F, Johannes R 2011 Fluka: a multi-particle transport code. (Italian National Institute for Nuclear Physics (INFN) and European Organization for Nuclear Research (CERN))
[4]	I Ferrari R A, Mairani A, Paganetti H，Parodi K, Sala P 2011 Phys. Med. Biol. 56 4001
[5]	Ju Z P, Cao W F, Liu X W 2009 Acta Phys. Sin. 58 174 (in Chinese) [鞠志萍, 曹午飞, 刘小伟 2009 物理学报 58 174]
[6]	Ju Z P, Cao W F, Liu X W 2010 Acta Phys. Sin. 59 199 (in Chinese) [鞠志萍, 曹午飞，刘小伟 2010物理学报 59 199]
[7]	Wang Y G, Luo Z M 2000 Acta Phys. Sin. 49 1639 (in Chinese) [王营冠, 罗正明 2000物理学报 49 1639]
[8]	Bortfeld T 1997 Med. Phys. 24 2024

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