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Use of the two-point-source -P1 approximation model for recovery of optical parameters in biological tissue

Qi Bei-Bei Liu Ying Jia Guang-Yi Liu Xiao-Jun

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Use of the two-point-source -P1 approximation model for recovery of optical parameters in biological tissue

Qi Bei-Bei, Liu Ying, Jia Guang-Yi, Liu Xiao-Jun
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  • Based on a theoretical model for spatial diffusion reflection with two-point-source -P1 approximation to the radiative transport equation for a semi-infinite homogeneous turbid medium, the optical absorption coefficient a, reduced scattering coefficient ' s, and the second-order parameter of the medium are recovered from the measurement data of the reflectance by the nonlinear least squares method. The results show that the two-point-source -P1 approximation can give more satisfactory results for describing irradiance distribution close to source when the source-detector separation is larger than one transport mean free path. We can also obtain the anisotropy factor g according to the relationship between and ' s. This study is of great significance for the measurement of the optical properties of biological tissues and the application of diffuse reflectance spectroscopy technology.
    [1]

    Zhang Z X 2008 New Technology and Applications of Biomedical Photonics (Beijing: Science Press) (in Chinese) [张镇西 2008 生物医学光子学新技术及应用 (北京:科学出版社)]

    [2]
    [3]

    Tuchin V V 2007 Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis (Bellingham: SPIE Press)

    [4]

    Wei H J, Xing D, Wu G Y 2004 Chin. J. Lasers 31 305 (in Chinese) [魏华江、邢 达、巫国勇 2004 中国激光 31 305]

    [5]
    [6]
    [7]

    Venugopalan V, You J S, Tromberg B J 1998 Phys. Rev. E 58 2395

    [8]

    Joseph J H, Wiscombe W J, Weinman J A 1976 J. Atmos. Sci. 33 2452

    [9]
    [10]
    [11]

    Hayakawa C K, Hill B Y, You J S 2004 Appl. Opt. 43 4577

    [12]
    [13]

    You J S, Hayakawa C K, Venugopalan V 2005 Phys. Rev. E 72 021903

    [14]

    Seo I, Hayakawa C K, Venugopalan V 2008 Med. Phys. 35 681

    [15]
    [16]

    Chai C G, Chen Y Q, Li P C, Luo Q M 2007 Appl. Opt. 46 4843

    [17]
    [18]
    [19]

    Chai C G, Chen Y Q, Zeng S Q, Luo Q M 2008 J. Mod. Opt. 55 1375

    [20]

    Kim A D 2004 J. Opt. Soc. Am. A 21 820

    [21]
    [22]
    [23]

    Tian H J, Liu Y, Wang L J, Zhang Z B, Xiao L F 2009 Acta Phys. Sin. 58 243 (in Chinese) [田会娟、刘 迎、王利军、张智卜、肖立峰 2009 物理学报 58 243]

    [24]
    [25]

    Wang R, Liu Y 2010 Chin. J. Lasers 37 1147 (in Chinese) [王 锐、刘 迎 2010 中国激光 37 1147]

    [26]
    [27]

    Groenhuis R A J, Ferwerda H A, Bosch J J T 1983 Appl. Opt. 22 2456

    [28]

    Wang L H, Jacques S L, Zheng L Q 1995 Comput. Meth. Prog. Biol. 47 131

    [29]
  • [1]

    Zhang Z X 2008 New Technology and Applications of Biomedical Photonics (Beijing: Science Press) (in Chinese) [张镇西 2008 生物医学光子学新技术及应用 (北京:科学出版社)]

    [2]
    [3]

    Tuchin V V 2007 Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis (Bellingham: SPIE Press)

    [4]

    Wei H J, Xing D, Wu G Y 2004 Chin. J. Lasers 31 305 (in Chinese) [魏华江、邢 达、巫国勇 2004 中国激光 31 305]

    [5]
    [6]
    [7]

    Venugopalan V, You J S, Tromberg B J 1998 Phys. Rev. E 58 2395

    [8]

    Joseph J H, Wiscombe W J, Weinman J A 1976 J. Atmos. Sci. 33 2452

    [9]
    [10]
    [11]

    Hayakawa C K, Hill B Y, You J S 2004 Appl. Opt. 43 4577

    [12]
    [13]

    You J S, Hayakawa C K, Venugopalan V 2005 Phys. Rev. E 72 021903

    [14]

    Seo I, Hayakawa C K, Venugopalan V 2008 Med. Phys. 35 681

    [15]
    [16]

    Chai C G, Chen Y Q, Li P C, Luo Q M 2007 Appl. Opt. 46 4843

    [17]
    [18]
    [19]

    Chai C G, Chen Y Q, Zeng S Q, Luo Q M 2008 J. Mod. Opt. 55 1375

    [20]

    Kim A D 2004 J. Opt. Soc. Am. A 21 820

    [21]
    [22]
    [23]

    Tian H J, Liu Y, Wang L J, Zhang Z B, Xiao L F 2009 Acta Phys. Sin. 58 243 (in Chinese) [田会娟、刘 迎、王利军、张智卜、肖立峰 2009 物理学报 58 243]

    [24]
    [25]

    Wang R, Liu Y 2010 Chin. J. Lasers 37 1147 (in Chinese) [王 锐、刘 迎 2010 中国激光 37 1147]

    [26]
    [27]

    Groenhuis R A J, Ferwerda H A, Bosch J J T 1983 Appl. Opt. 22 2456

    [28]

    Wang L H, Jacques S L, Zheng L Q 1995 Comput. Meth. Prog. Biol. 47 131

    [29]
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Publishing process
  • Received Date:  02 March 2011
  • Accepted Date:  26 July 2011
  • Published Online:  05 June 2011

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