In this paper, the energy structure and the forbidden M1,M2,E2 transition probabilities between the ground state 3s23p63d10 1S0 and the low-lying excited 3s23p63d94l, 3s23p53d104l and 3s3p63d104l (l=s,p,d,f)states have been calculated for Ni-like ions of Z=45—95, by using GRASP92 package and REOS99 code based on the relativistic multi-configuration Dirac-Fock method. By Analyzing the effects of strong configuration interaction (CI) existing in Ni-like sequence, the abnormalies of forbidden transition probabilities existing in several highly charged Ni-like ions are explained,and some general laws for the influence of CI on forbidden transition probabilities are discussed.