In this paper we discuss the preparation of Tb1-xDyxFe2－y/Pb(Zr,Ti)O3 trilayers and a technique of single magnetic field-driven magnetoelectric coupling. A colossal ME voltage has been measured in the trilayers with the technique. The results obtained are far from that observed from that driven by two-field ME effect for the same material and probably predict some new physical effect. This technique can be expected to simplify the applications of ME effect in some fields.