As a new type of nano-semiconductor material, Cu2S quantum dot (QD) has received much attention due to its particular chemical and optical properties. In this paper we use COMSOL Multiphysics 4.2a software, select Radio Frequency model and combine the Maxwell theory to simulate and analyze the factors influencing Cu2S with its SPR. By using the Kretschmann prism coupling model, changing the QD size, the refractive index of QD solvent, the wavelength of incident light and coated substance of the QD, the data about how the SPR appears and the effectsof those factors are obtained. So the simulation results will be a theoretical foundation and reference to the further study.