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物理学在肿瘤细胞的极性及迁移研究中的应用

王璟 杨根 刘峰

物理学在肿瘤细胞的极性及迁移研究中的应用

王璟, 杨根, 刘峰
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  • 肿瘤细胞和所处微环境的物理性质, 以及它们之间的相互物理作用对于肿瘤的产生、发展与转移都有极大的影响, 这使得从物理学角度探索肿瘤研究成为了必然趋势. 肿瘤转移是癌症致死的最大因素, 而肿瘤细胞迁移中的极化是肿瘤转移的重要一步. 本文总结了物理学实验和模型在揭示细胞迁移和极化机理方面的贡献. 实验上应用最新的微流控芯片技术与表面微模型化技术等手段, 研究空间维度、黏附行为、机械力等物理信号对于细胞极性的建立与保持以及细胞迁移行为的影响后, 发现物理信号与生化反应之间的相互耦合对于细胞迁移有着至关重要的作用; 理论上基于扩散反应方程, 已经建立了一系列表征细胞极化的模型. 今后的研究将结合物理实验建立肿瘤细胞迁移中的极化模型, 进而发展针对肿瘤细胞感知物理信号的新的治疗肿瘤转移方法.
    • 基金项目: 国家自然科学基金(批准号: 11434001)和科技部重大仪器专项(批准号: 2012YQ030142)资助的课题.
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    Byun S, Son S, Amodei D, Cermak N, Shaw J, Kang J H, Hecht V C, Winslow M M, Jacks T, Mallick P, Manalis S R 2013 Proc. Natl. Acad. Sci. U. S. A. 110 7580

    [7]

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    [9]

    Indra I, Undyala V, Kandow C, Thirumurthi U, Dembo M, Beningo K A 2011 Phys. Biol. 8 015015

    [10]

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    [11]

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    [12]

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    [13]

    Liu L, Sun B, Pedersen J N, Yong K-M A, Getzenberg R H, Stone H A, Austin R H 2011 Proc. Natl. Acad. Sci. U. S. A. 108 6853

    [14]

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    [15]

    Tsai JH, Yang J 2013 Genes. Dev. 27 2192

    [16]

    Zhang J, Tian X J, Zhang H, Teng Y, Li R, Bai F, Elankumaran S, Xing J 2014 Sci. Signal. 7 ra91

    [17]

    Lu M, Jolly M K, Onuchic J, Ben-Jacob E 2014 Cancer. Res. 74 4574

    [18]

    Wolf K, Alexander S, Schacht V, Coussens LM, Andrian von UH, van Rheenen J, Deryugina E, Friedl P 2009 Semin. Cell. Dev. Biol. 20 931

    [19]

    Stroka K M, Konstantopoulos K 2014 Am. J. Physiol. Cell. Physiol. 306 C98

    [20]

    Gilmore A P, Burridge K 1996 Nature 381 531

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    Miyamoto S, Teramoto H, Coso O A, Gutkind J S, Burbelo P D, Akiyama S K, Yamada K M 1995 J. Cell. Biol. 131 791

    [22]

    Cukierman E, Pankov R, Stevens DR, Yamada KM 2001 Science 294 1708

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    Fraley S I, Feng Y, Krishnamurthy R, Kim D H, Celedon A, Longmore G D, Wirtz D 2010 Nat. Cell. Biol. 12 598

    [25]

    Petroll W M, Ma L, Jester J V 2003 J. Cell. Sci. 116 1481

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    Fraley S I, Feng Y, Giri A, Longmore G D, Wirtz D 2012 Nat. Commun. 3 719

    [27]

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    [29]

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    [30]

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    [31]

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    Srinivasan S, Wang F, Glavas S, Ott A, Hofmann F, Aktories K, Kalman D, Bourne H R 2003 J. Cell. Biol. 160 375

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    Gao L, Shao L, Chen B C, Betzig E 2014 Nat. Protoc. 9 1083

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    Kreso A, Dick J E 2014 Cell. Stem. Cell. 14 275

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    Yang G, Quan Y, Wang W, Fu Q, Wu J, Mei T, Li J, Tang Y, Luo C, Ouyang Q, Chen S, Wu L, Hei T K, Wang Y 2012 Br. J. Cancer. 106 1512

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  • 收稿日期:  2014-12-02
  • 修回日期:  2015-02-06
  • 刊出日期:  2015-03-05

物理学在肿瘤细胞的极性及迁移研究中的应用

  • 1. 北京大学物理学院, 核物理与核技术国家重点实验室, 北京 100891;
  • 2. 北京大学定量生物中心, 北京 100871
    基金项目: 

    国家自然科学基金(批准号: 11434001)和科技部重大仪器专项(批准号: 2012YQ030142)资助的课题.

摘要: 肿瘤细胞和所处微环境的物理性质, 以及它们之间的相互物理作用对于肿瘤的产生、发展与转移都有极大的影响, 这使得从物理学角度探索肿瘤研究成为了必然趋势. 肿瘤转移是癌症致死的最大因素, 而肿瘤细胞迁移中的极化是肿瘤转移的重要一步. 本文总结了物理学实验和模型在揭示细胞迁移和极化机理方面的贡献. 实验上应用最新的微流控芯片技术与表面微模型化技术等手段, 研究空间维度、黏附行为、机械力等物理信号对于细胞极性的建立与保持以及细胞迁移行为的影响后, 发现物理信号与生化反应之间的相互耦合对于细胞迁移有着至关重要的作用; 理论上基于扩散反应方程, 已经建立了一系列表征细胞极化的模型. 今后的研究将结合物理实验建立肿瘤细胞迁移中的极化模型, 进而发展针对肿瘤细胞感知物理信号的新的治疗肿瘤转移方法.

English Abstract

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