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Using a long-distance microscope imaging system and a lock-in phase integrate technique, optical measurements demonstrate that the evolutional behaviors of a phospholipid-shelled micro-bubble, a kind of ultrasound contrast agent, under two ultrasound frequencies and different pressures. Dozens of frames of an oscillating microbubble for one acoustic cycle are captured. The experimental data of micro-bubble diameter are fit by the numerical calculations of the Hoff model and the Rayleigh-Plesset model, respectively. The results show the good agreement between experimental data and the theoretical calculation in the Hoff model. In addition, the spectral analysis based on the experimental data indicates that the relative intensity of the second harmonic increases with the driving pressure amplitude.
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Keywords:
- encapsulated microbubbles /
- lock-in integrate imaging method /
- spectra
[1] Goldberg B B, Raichlen J S, Forsberg F 2001 Ultrasound Contrast Agents-Basic Principles and Clinical Applications (2nd Ed.) (London:Martin Dunitz) p25
[2] Shankar P M, Krishna P D, Newhouse V L 1998 Ultrasound Med. Biol. 24 395
[3] Bloch S H, Dayton P A, Ferrara K W 2004 IEEE Eng. Med. Biol. Mag. 23 18
[4] Robertson V J, Baker K G 2001 Phys. Ther. 81 1339
[5] Church C C 1995 J. Acoust. Soc. Am. 97 1510
[6] Hoff L, Sontum P C, Hovem J M 2000 J. Acoust. Soc. Am. 107 2272
[7] Marmottant P, van der Meer S, Emmer M, Versluis M, de Jong N, Hilgenfeldt S, Lohse D 2005 J. Acoust. Soc. Am. 118 3499
[8] de Jong N, Frinking P J A, Bouakaz A, Goorden M, Schourmans T, Jingping X, Mastik F 2000 Ultrasound Med. Biol. 26 487
[9] Chomas J E, Dayton P, May D, Ferrara K 2001 J. Biomed. Opt. 6 41
[10] Postema M, Bouakaaz A, Chin C T, de Jong N 2003 IEEE Trans. Ultrason. Ferroelect. Freq. Contr. 50 523
[11] Chen H, Kreider W, Brayman A A, Bailey M R, Matula T J 2011 Phys. Rev. Lett. 106 034301
[12] Wolfrum B, Mettin R, Lauterborn W 2002 Appl. Phys. Lett. 81 5060
[13] Liu Y N, Chen W Z, Huang W, Gao X X 2005 Chin. Sci. Bull. 50 2458 (in Chinese) [刘亚楠, 陈伟中, 黄威, 高娴娴 2005 科学通报 50 2458]
[14] Huang W, Chen W Z, Liu Y N, Gao X X 2006 Ultrasonics 44 e407
[15] Matula T J 2000 Ultrasonics 38 559
[16] Keller J B, Miksis M 1980 J. Acoust. Soc. Am. 68 628
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[1] Goldberg B B, Raichlen J S, Forsberg F 2001 Ultrasound Contrast Agents-Basic Principles and Clinical Applications (2nd Ed.) (London:Martin Dunitz) p25
[2] Shankar P M, Krishna P D, Newhouse V L 1998 Ultrasound Med. Biol. 24 395
[3] Bloch S H, Dayton P A, Ferrara K W 2004 IEEE Eng. Med. Biol. Mag. 23 18
[4] Robertson V J, Baker K G 2001 Phys. Ther. 81 1339
[5] Church C C 1995 J. Acoust. Soc. Am. 97 1510
[6] Hoff L, Sontum P C, Hovem J M 2000 J. Acoust. Soc. Am. 107 2272
[7] Marmottant P, van der Meer S, Emmer M, Versluis M, de Jong N, Hilgenfeldt S, Lohse D 2005 J. Acoust. Soc. Am. 118 3499
[8] de Jong N, Frinking P J A, Bouakaz A, Goorden M, Schourmans T, Jingping X, Mastik F 2000 Ultrasound Med. Biol. 26 487
[9] Chomas J E, Dayton P, May D, Ferrara K 2001 J. Biomed. Opt. 6 41
[10] Postema M, Bouakaaz A, Chin C T, de Jong N 2003 IEEE Trans. Ultrason. Ferroelect. Freq. Contr. 50 523
[11] Chen H, Kreider W, Brayman A A, Bailey M R, Matula T J 2011 Phys. Rev. Lett. 106 034301
[12] Wolfrum B, Mettin R, Lauterborn W 2002 Appl. Phys. Lett. 81 5060
[13] Liu Y N, Chen W Z, Huang W, Gao X X 2005 Chin. Sci. Bull. 50 2458 (in Chinese) [刘亚楠, 陈伟中, 黄威, 高娴娴 2005 科学通报 50 2458]
[14] Huang W, Chen W Z, Liu Y N, Gao X X 2006 Ultrasonics 44 e407
[15] Matula T J 2000 Ultrasonics 38 559
[16] Keller J B, Miksis M 1980 J. Acoust. Soc. Am. 68 628
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