搜索

x

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

开放式多通道多芯少模光纤表面等离子体共振生物传感器

肖士妍 贾大功 聂安然 余辉 吉喆 张红霞 刘铁根

引用本文:
Citation:

开放式多通道多芯少模光纤表面等离子体共振生物传感器

肖士妍, 贾大功, 聂安然, 余辉, 吉喆, 张红霞, 刘铁根

Multi-channel few-mode multicore fiber based surface plasmon resonance biosensor with open air-hole

Xiao Shi-Yan, Jia Da-Gong, Nie An-Ran, Yu Hui, Ji Zhe, Zhang Hong-Xia, Liu Tie-Gen
PDF
HTML
导出引用
  • 基于多芯少模光纤结构特性, 提出了一种具有开放式感知通道的多芯少模光纤表面等离子体共振生物传感器. 建立了多芯少模光纤表面等离子体共振生物传感器的模型, 利用有限元方法分析了纤芯气孔间距、膜层厚度、膜层材料以及不同传输模式对传感器性能的影响, 并讨论了传感器多通道感知性能. 仿真分析发现, 纤芯气孔间距决定了倏逝波的耦合强度, 材料特性和模式共同影响了表面等离子体共振峰的位置和灵敏度. 经过计算可知: 当单个凹槽传感通道上沉积100 nm铟锡氧化物薄膜, 分析物折射率范围为1.33—1.39时, LP11ax模式对应的平均光谱灵敏度为12048 nm/RIU(其中RIU为折射率单位, 即refractive index unit), 最高灵敏度为20824.66 nm/RIU, 最大折射率分辨率可达4.8 × 10–6 RIU; 当光纤外围凹槽镀上不同厚度的金膜、银膜和铟锡氧化物膜时, 既可以单独探测生物物质, 也可以联合检测同一生物物质, 实现了传感通道的控制灵活性和测试物质的多样性.
    Based on the structural characteristics of the few-mode multicore fiber (FM-MCF), a multi-channel FM-MCF surface plasmon resonance (SPR) biosensor with open air-hole is presented. Due to the air-hole distribution of the FM-MCF, the six outer air-holes naturally become open air-holes, i.e. groove sensing channels, fabricated by chemical etching. Then, compared with D-shape structure, tapered structure of fiber and air-hole of photonic crystal fiber (PCF), the open groove structure is easy to accommodate the liquid analyte. In order to obtain better sensing performance, a sensing model of the presented FM-MCF SPR biosensor with sensitive dielectric layer is established and numerical simulations are performed using the finite element method. In the simulations, the effect of core-hole distance, coating thickness, sensing dielectrics, transmission modes in optical fiber on the sensing performance as well as the role of multi-channel are analyzed. The simulation results show that when the air-hole is tangent to the core (d = 0 μm), the FM-MCF SPR biosensor has the better performance because the core-hole distance d determines the leakage intensity of the evanescent wave. As the evanescent field excited by high-order mode (LP11ax mode) is stronger than that by fundamental mode (LP01x mode), the performance of biosensors for SPR excitation by using high-order mode is better than by using fundamental mode. Meanwhile when the coating thickness of gold, silver and indium tin oxides (ITOs) is 40 nm, 30 nm and 100 nm respectively, the FWHM of loss spectrum reaches a minimum value, which means that the presented biosensor has the better performance in this sense. For the case of different sensing dielectrics, it is observed that the resonance wavelength of gold and silver film are in the visible wavelength range, while the ITO is at near-infrared wavelength. Then it is useful for our biosensor to simultaneously detect many liquid analytes in one SPR transmittance spectrum. In addition, the calculation results also show that when one of the groove channels is coated with 100 nm ITO for the LP11ax mode, the FM-MCF SPR biosensor has a highest sensitivity of 20824.66 nm/RIU and refractive index (RI) resolution is 4.8 × 10–6 RIU with the surrounding RI changing from 1.33 to 1.39, in which the RI of bovine serum albumin (BSA) solution, human Immunoglobulin G and C-reactive protein can be detected. Moreover, when the outer groove channels of our biosensor are coated with gold, silver and ITO film with different thickness, many biological liquid analytes can be detected separately or the same biological liquid analyte can be detected jointly, which reveals that the control flexibility of the groove sensing channel and the diversity of the detection analytes .
      通信作者: 贾大功, dagongjia@tju.edu.cn ; 余辉, yuhui@tju.edu.cn
    • 基金项目: 国家级-国家自然科学基金(61875152)
      Corresponding author: Jia Da-Gong, dagongjia@tju.edu.cn ; Yu Hui, yuhui@tju.edu.cn
    [1]

    Cooper M A 2002 Nat. Rev. Drug Discov. 1 515Google Scholar

    [2]

    Borisov S M, Wolfbeis O S 2008 Chem. Rev. 108 423Google Scholar

    [3]

    李加东, 程珺洁, 苗斌, 魏晓玮, 张志强, 黎海文, 吴东岷 2014 物理学报 63 070204Google Scholar

    Li J D, Cheng J J, Miao B, Wei X W, Zhang Z Q, Li H W, Wu D M 2014 Acta Phys. Sin. 63 070204Google Scholar

    [4]

    Shankaran D R, Gobi K V, Miura N 2007 Sensor Actuat. B-Chem. 121 158Google Scholar

    [5]

    Fan X D, White I M, Shopova S I, Zhu H Y, Suter J D, Sun Y Z 2008 Anal. Chim. Acta 620 8Google Scholar

    [6]

    Gupta B D, Verma R K 2009 J. Sens. 2009 1

    [7]

    Homola J 2008 Chem. Rev. 108 462Google Scholar

    [8]

    Velázquez-González J S, Monzón-Hernández D, Moreno-Hernández D, Martínez-Piñón F, Hernández-Romano I 2017 Sensor Actuat. B-Chem. 242 912Google Scholar

    [9]

    施伟华, 尤承杰, 吴静 2015 物理学报 64 224221Google Scholar

    Shi W H, You C J, Wu J 2015 Acta Phys. Sin. 64 224221Google Scholar

    [10]

    冯李航, 曾捷, 梁大开, 张为公 2013 物理学报 62 124207Google Scholar

    Feng L H, Zeng J, Liang D K, Zhang W G 2013 Acta Phys. Sin. 62 124207Google Scholar

    [11]

    张海志 2003 生物学通报 38 1Google Scholar

    Zhang H Z 2003 Bull. Biol. 38 1Google Scholar

    [12]

    Kassani S H, Khazaeinezhad R, Jung Y M, Kobelke J, Oh K 2015 IEEE Photonics J. 7 1Google Scholar

    [13]

    Liu C, Yang L, Lu X L, Liu Q, Wang F M, Lv J W, Sun T, Mu H W, Chu P K 2017 Opt. Express 25 14227Google Scholar

    [14]

    Yang Z, Xia L, Li C, Chen X, Liu D M 2019 Opt. Commun. 430 195Google Scholar

    [15]

    Wei Y, Su Y D, Liu C L, Zhang Y H, Nie X F, Liu Z H, Zhang Y, Peng F 2017 Opt. Express 25 21841Google Scholar

    [16]

    Li A, Wang Y F, Hu Q, Shieh W 2015 Opt. Express 23 1139Google Scholar

    [17]

    Sakaguchi J, Klaus W, Mendinueta J M D, Puttnam B J, Luís R S, Awaji Y, Wada N, Hayashi T, Nakanishi T, Watanabe T, Kokubun Y, Takahata T, Kobayashi T 2015 J. Lightwave Technol. 34 93Google Scholar

    [18]

    Xia C, Amezcua-Correa R, Bai N, Antonio-Lopez E, Arrioja D M, Schulzgen A, Richardson M, Liñares J, Montero C, Mateo E, Zhou X, Li G F 2012 IEEE Photonics Technol. Lett. 24 1914Google Scholar

    [19]

    Rakić A D, Djurišić A B, Elazar J M, Majewski M L 1998 Appl. Opt. 37 5271Google Scholar

    [20]

    Wang Y J, Dong J L, Luo Y H, Tang J Y, Lu H H, Yu J H, Guan H Y, Zhang J, Chen Z 2017 IEEE Photonics J. 9 1Google Scholar

    [21]

    Dong J L, Zhang Y X, Wang Y J, Yang F, Hu S Q, Chen Y F, Zhu W G, Qiu W T, Guan H Y, Lu H H, Yu J H, Zhong Y C, Zhang J, Luo Y H, Chen Z 2019 Opt. Express 27 11348Google Scholar

    [22]

    Zheng Y F, Lang T T, Cao B B, Jin J J, Dong R Q, Feng H 2018 Opt. Fiber Technol. 46 179Google Scholar

    [23]

    Wang W J, Mai Z G, Chen Y Z, Wang J Q, Li L, Su Q N, Li X J, Hong X M 2017 Sci. Rep. 7 1Google Scholar

  • 图 1  (a) FM-MCF SPR生物传感器的横截面; (b) FM-MCF横截面; (c) FEM网格划分

    Fig. 1.  (a) Cross section of the FM-MCF SPR biosensor; (b) cross section of the FM-MCF; (c) FEM mesh for calculation.

    图 2  氢氟酸腐蚀FM-MCF过程中纤芯和气孔间距d的变化 (a)包层与最外侧气孔相切; (b)腐蚀气孔与纤芯恰好相切; (c)纤芯被腐蚀; 下方的插图是红色区域的放大示意图

    Fig. 2.  The core-hole distance d variation during using hydrofluoric acid to fabricate the groove channel: (a) Cladding is tangent to the outermost air-holes; (b) air-holes are tangent to the cores; (c) fiber cores are also etched. The inserts below are zoom-in of red region.

    图 3  (a)当na = 1.33—1.36时不同d的芯模损耗光谱曲线; (b)不同RI下d对共振波长和灵敏度的影响; (c) d与传感器FWHM和FOM的关系

    Fig. 3.  (a) Loss spectra of the core mode with different d when na = 1.33—1.36; (b) the effect of d on both resonance wavelength and sensitivity with various RI; (c) relations between d and FWHM as well as FOM of the sensor.

    图 4  不同膜层厚度下的芯模损耗光谱 (a)金膜; (b)银膜; (c) ITO

    Fig. 4.  Loss spectra of the core mode for different coating thickness (t): (a) Au; (b) Ag; (c) ITO.

    图 5  na变化时传感器的共振光谱 (a)金膜厚度为40 nm; (b) ITO膜厚度为100 nm

    Fig. 5.  Loss spectra of the sensor with na increasing: (a) tAu = 40 nm; (b) tITO = 100 nm.

    图 6  待测物RI与共振波长之间的关系 (a) 金膜厚度为40 nm; (b) ITO膜为100 nm

    Fig. 6.  Relations between na and resonance wavelength for different t: (a) tAu = 40 nm; (b) tITO = 100 nm.

    图 7  (a) LP01x模的电场分布; (b) LP01x模的光场分布; (c) LP11ax模的电场分布; (d) LP11ax模的光场分布

    Fig. 7.  (a) Electric field distributions of LP01x; (b) optical field distributions of LP01x; (c) electric field distributions of LP11ax; (d) optical field distributions of LP11ax.

    图 8  (a) LP11ax模激发的光谱损耗曲线; (b) LP11ax模激发时na与共振波长之间的关系

    Fig. 8.  (a) Loss spectra excited by LP11ax mode; (b) relations between na and resonance wavelength at LP11ax mode.

    图 9  三种生物物质传感时光谱损耗 (a) 1通道na = 1.35, 金膜; (b) 2通道na = 1.34, 银膜; (c) 5通道na = 1.33, ITO膜; 插图是共振发生时通道中光场分布

    Fig. 9.  The loss spectra of three bio-substances sensing: (a) Channel 1 for Au coating with na = 1.35; (b) channel 2 for Ag coating with na = 1.34; (c) channel 5 for ITO coating with na = 1.33. Insets are optical field distributions for three channels.

    图 10  na从1.33增加到1.34时, 多通道传感检测同种物质时的光谱损耗 (a) 1通道; (b) 2通道; (c) 5通道

    Fig. 10.  Loss spectra for detecting one bio-substance simultaneously using multi-channel when na increases from 1.33 to 1.34: (a) Channel 1; (b)channel 2; (c) channel 5.

  • [1]

    Cooper M A 2002 Nat. Rev. Drug Discov. 1 515Google Scholar

    [2]

    Borisov S M, Wolfbeis O S 2008 Chem. Rev. 108 423Google Scholar

    [3]

    李加东, 程珺洁, 苗斌, 魏晓玮, 张志强, 黎海文, 吴东岷 2014 物理学报 63 070204Google Scholar

    Li J D, Cheng J J, Miao B, Wei X W, Zhang Z Q, Li H W, Wu D M 2014 Acta Phys. Sin. 63 070204Google Scholar

    [4]

    Shankaran D R, Gobi K V, Miura N 2007 Sensor Actuat. B-Chem. 121 158Google Scholar

    [5]

    Fan X D, White I M, Shopova S I, Zhu H Y, Suter J D, Sun Y Z 2008 Anal. Chim. Acta 620 8Google Scholar

    [6]

    Gupta B D, Verma R K 2009 J. Sens. 2009 1

    [7]

    Homola J 2008 Chem. Rev. 108 462Google Scholar

    [8]

    Velázquez-González J S, Monzón-Hernández D, Moreno-Hernández D, Martínez-Piñón F, Hernández-Romano I 2017 Sensor Actuat. B-Chem. 242 912Google Scholar

    [9]

    施伟华, 尤承杰, 吴静 2015 物理学报 64 224221Google Scholar

    Shi W H, You C J, Wu J 2015 Acta Phys. Sin. 64 224221Google Scholar

    [10]

    冯李航, 曾捷, 梁大开, 张为公 2013 物理学报 62 124207Google Scholar

    Feng L H, Zeng J, Liang D K, Zhang W G 2013 Acta Phys. Sin. 62 124207Google Scholar

    [11]

    张海志 2003 生物学通报 38 1Google Scholar

    Zhang H Z 2003 Bull. Biol. 38 1Google Scholar

    [12]

    Kassani S H, Khazaeinezhad R, Jung Y M, Kobelke J, Oh K 2015 IEEE Photonics J. 7 1Google Scholar

    [13]

    Liu C, Yang L, Lu X L, Liu Q, Wang F M, Lv J W, Sun T, Mu H W, Chu P K 2017 Opt. Express 25 14227Google Scholar

    [14]

    Yang Z, Xia L, Li C, Chen X, Liu D M 2019 Opt. Commun. 430 195Google Scholar

    [15]

    Wei Y, Su Y D, Liu C L, Zhang Y H, Nie X F, Liu Z H, Zhang Y, Peng F 2017 Opt. Express 25 21841Google Scholar

    [16]

    Li A, Wang Y F, Hu Q, Shieh W 2015 Opt. Express 23 1139Google Scholar

    [17]

    Sakaguchi J, Klaus W, Mendinueta J M D, Puttnam B J, Luís R S, Awaji Y, Wada N, Hayashi T, Nakanishi T, Watanabe T, Kokubun Y, Takahata T, Kobayashi T 2015 J. Lightwave Technol. 34 93Google Scholar

    [18]

    Xia C, Amezcua-Correa R, Bai N, Antonio-Lopez E, Arrioja D M, Schulzgen A, Richardson M, Liñares J, Montero C, Mateo E, Zhou X, Li G F 2012 IEEE Photonics Technol. Lett. 24 1914Google Scholar

    [19]

    Rakić A D, Djurišić A B, Elazar J M, Majewski M L 1998 Appl. Opt. 37 5271Google Scholar

    [20]

    Wang Y J, Dong J L, Luo Y H, Tang J Y, Lu H H, Yu J H, Guan H Y, Zhang J, Chen Z 2017 IEEE Photonics J. 9 1Google Scholar

    [21]

    Dong J L, Zhang Y X, Wang Y J, Yang F, Hu S Q, Chen Y F, Zhu W G, Qiu W T, Guan H Y, Lu H H, Yu J H, Zhong Y C, Zhang J, Luo Y H, Chen Z 2019 Opt. Express 27 11348Google Scholar

    [22]

    Zheng Y F, Lang T T, Cao B B, Jin J J, Dong R Q, Feng H 2018 Opt. Fiber Technol. 46 179Google Scholar

    [23]

    Wang W J, Mai Z G, Chen Y Z, Wang J Q, Li L, Su Q N, Li X J, Hong X M 2017 Sci. Rep. 7 1Google Scholar

  • [1] 沈艳丽, 史冰融, 吕浩, 张帅一, 王霞. 基于石墨烯的Au纳米颗粒增强染料随机激光. 物理学报, 2022, 71(3): 034206. doi: 10.7498/aps.71.20211613
    [2] 王彦, 韩颖, 李增辉, 龚琳, 王璐瑶, 李曙光. 一种沟槽辅助气孔隔离的低串扰高密度异质多芯少模光纤. 物理学报, 2022, 71(2): 024205. doi: 10.7498/aps.71.20210974
    [3] 王彦, 韩颖, 李增辉, 龚琳, 王璐瑶, 李曙光. 一种沟槽辅助气孔隔离的低串扰高密度异质多芯少模光纤*. 物理学报, 2021, (): . doi: 10.7498/aps.70.20210974
    [4] 丁子平, 廖健飞, 曾泽楷. 基于表面等离子体共振的新型超宽带微结构光纤传感器研究. 物理学报, 2021, 70(7): 074207. doi: 10.7498/aps.70.20201477
    [5] 孙小亮, 陈长虹, 孟德佳, 冯士高, 于洪浩. 复合金属光栅模式分离与高性能气体传感器应用. 物理学报, 2015, 64(14): 147302. doi: 10.7498/aps.64.147302
    [6] 施伟华, 尤承杰, 吴静. 基于表面等离子体共振和定向耦合的D形光子晶体光纤折射率和温度传感器. 物理学报, 2015, 64(22): 224221. doi: 10.7498/aps.64.224221
    [7] 廖文英, 范万德, 李海鹏, 隋佳男, 曹学伟. 准晶体结构光纤表面等离子体共振传感器特性研究. 物理学报, 2015, 64(6): 064213. doi: 10.7498/aps.64.064213
    [8] 李国龙, 何力军, 李进, 李学生, 梁森, 高忙忙, 袁海雯. 纳米银增强聚合物太阳能电池光吸收的研究. 物理学报, 2013, 62(19): 197202. doi: 10.7498/aps.62.197202
    [9] 荆庆丽, 杜春光, 高健存. 表面等离子共振现象的新应用——微弱磁场的测量. 物理学报, 2013, 62(3): 037302. doi: 10.7498/aps.62.037302
    [10] 张喆, 柳倩, 祁志美. 基于金银合金薄膜的近红外表面等离子体共振传感器研究. 物理学报, 2013, 62(6): 060703. doi: 10.7498/aps.62.060703
    [11] 冯李航, 曾捷, 梁大开, 张为公. 契形结构光纤表面等离子体共振传感器研究. 物理学报, 2013, 62(12): 124207. doi: 10.7498/aps.62.124207
    [12] 邹志宇, 刘晓芳, 曾敏, 杨白, 于荣海, 姜鹤, 唐瑞鹤, 吴章奔. 电场辅助溶解法实现玻璃表面金纳米粒子的形貌控制. 物理学报, 2012, 61(10): 104208. doi: 10.7498/aps.61.104208
    [13] 闫红丹, Peter Lemmens, Johannes Ahrens, Martin Bröring, Sven Burger, Winfried Daum, Gerhard Lilienkamp, Sandra Korte, Aidin Lak, Meinhard Schilling. 基于表面等离子体耦合的高密度金纳米线阵列. 物理学报, 2012, 61(23): 237105. doi: 10.7498/aps.61.237105
    [14] 钟明亮, 李山, 熊祖洪, 张中月. 十字形银纳米结构的表面等离子体光子学性质. 物理学报, 2012, 61(2): 027803. doi: 10.7498/aps.61.027803
    [15] 邱东江, 范文志, 翁圣, 吴惠桢, 王俊. 以表面等离子体为媒介的ZnO薄膜发光增强特性研究. 物理学报, 2011, 60(8): 087301. doi: 10.7498/aps.60.087301
    [16] 郝鹏, 吴一辉, 张平. 纳米金表面修饰与表面等离子体共振传感器的相互作用研究. 物理学报, 2010, 59(9): 6532-6537. doi: 10.7498/aps.59.6532
    [17] 龙拥兵, 张剑, 汪国平. 基于表面等离子体激元共振的飞秒抽运探测技术研究. 物理学报, 2009, 58(11): 7722-7726. doi: 10.7498/aps.58.7722
    [18] 朱宝华, 王芳芳, 张 琨, 马国宏, 顾玉宗, 郭立俊, 钱士雄. Au:TiO2和Au:Al2O3纳米颗粒复合膜的线性和非线性光学特性. 物理学报, 2008, 57(5): 3085-3092. doi: 10.7498/aps.57.3085
    [19] 洪小刚, 徐文东, 李小刚, 赵成强, 唐晓东. 数值模拟探针诱导表面等离子体共振耦合纳米光刻. 物理学报, 2008, 57(10): 6643-6648. doi: 10.7498/aps.57.6643
    [20] 朱宝华, 王芳芳, 张 琨, 马国宏, 郭立俊, 钱士雄. Ag:Bi2O3复合膜的线性和非线性光学性质. 物理学报, 2007, 56(7): 4024-4031. doi: 10.7498/aps.56.4024
计量
  • 文章访问数:  6976
  • PDF下载量:  159
  • 被引次数: 0
出版历程
  • 收稿日期:  2020-03-10
  • 修回日期:  2020-04-15
  • 上网日期:  2020-05-09
  • 刊出日期:  2020-07-05

/

返回文章
返回