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基于拟氨基酸编码方法的同义密码子的偏好性与结合强度的相关性研究

朱平 高雷 徐振源

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基于拟氨基酸编码方法的同义密码子的偏好性与结合强度的相关性研究

朱平, 高雷, 徐振源

Correlation between the usage degree of the synonymous codon and the strength of combination based on the quasi-amino acid coding

Zhu Ping, Gao Lei, Xu Zhen-Yuan
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  • 计算了基于拟氨基酸编码方法下的同义密码子的相对使用度,分析了78个人类基因(19967个密码子)中基于拟氨基酸编码方法下的同义密码子的偏好使用情况.石秀凡等的研究结果显示了人类基因中基于基因组基因编码方法下,对同义密码子的选择在所有密码子家族中仍都呈现明显一致的偏好.即偏好使用密码子-反密码子结合作用强的密码子,恰好是以 c结尾的密码子;且避免使用结合作用中度的密码子.依据结果和数据分析, 推测人类基因对密码子的选择除了受基因组结构中 isochore和基因签名的影响外,还和密码子-反密码子结合强度密切相
    The relative usage degree of the synonymous codon is computed and the use of preferences of the synonymous codon in 78 human genes(19967 codons) is analysed based on the quasi-amino acids coding. The results of Shi Xiufan et al. show that human genes clearly show the consistent preference in synonymous codon choice in all codon family based on the genomic genetic codes. That is, human genes prefer to use the codons with strong combination of the codon-anticodon, the codons ending with c, so that the use of the codons with moderate combination is avoided. The choice of codon in human genes is not only affected by the isochore and genome in the genome structure, but also related to the strength of combination with the codon-anticodon. All the above-mentioned factors affect the human genes,and so all the codon families clearly show the consistent preference to the synonymous codon. This study shows that the above-mentioned characteritics are more obvious when the method of quasi-amino acids coding is used.
    • 基金项目: 科技部国际科技合作基金(批准号: 2007DFA70670)和江南大学创新团队发展计划(批准号:2008CX002)资助的课题.
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  • PDF下载量:  1894
  • 被引次数: 0
出版历程
  • 收稿日期:  2008-06-19
  • 修回日期:  2008-07-31
  • 刊出日期:  2009-03-05

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