The synchronization problem for a chemical reaction system composed of two continuous stirring tank reactorv is explored. Based on Lyapunov stability theory, a new method is proposed to design the controlling function. The range of the coupling strength to realize the synchronization between the two chemical systems is investigated both for the case with static velocity and with periodically disturbed velocity of the input material. Numerical simulations are then performed to demonstrate the effectiveness of the proposed scheme, which show that the method is suitable for both the autonomous system and the non-autonomous system with periodic perturbation.