相移吸收二元性算法用于X射线混合衬度定量显微CT的可行性研究

刘慧强; 任玉琦; 周光照; 和友; 薛艳玲; 肖体乔

doi:10.7498/aps.61.078701

摘要

本文采用相移吸收二元性(PAD)相位恢复算法来实现混合衬度样品内部不同密度组分的定量成像, 采用数字模拟和实验研究验证该方法的可行性. 模拟结果表明, 对于三种不同材料其重构误差均小于1%, 且误差值随材料折射率的增大而减小. 利用上海光源X射线成像线站开展了实验研究, 结果表明用单距PAD相位恢复算法可获取样品的定量信息. 与模拟结果相比, 实验中的重构精度相对较低, 环状伪影可能是影响精度的主要原因. 模拟和实验研究过程中, 均只采用了一组单距投影数据. 可以认为, 相移吸收二元性算法可用于混合衬度样品的定量信息分析研究. 由于剂量相对较低, 应可适合于软组织和骨骼同时存在时生物医学样品的定量相衬CT研究.

关键词:

Abstract

Weak absorption is the main condition of conventional phase retrieval of in-line X-ray phase-contrast CT. The absorption of most samples, however, cannot be neglected in practice, it is needed to find new algorithms of attaining quantitative information. The phase retrieval algorithm of phase-attenuation duality (PAD) is used to realize the quantitative imaging of different density parts in a mixed contrast sample, and the digital simulation and experimental investigation are carried out in order to prove its feasibility in this paper. The simulated results show that the reconstructive errors of three materials are less than 1%, and the values decrease with the increase of refractive index. The experiment was carried out in the X-ray imaging and biological application beam-line of Shanghai Synchrotron Facility, and the results show that the PAD method can attain the sample quantitative information and the reconstructive accuracy is relatively low compared with that of simulation. Through the analysis of experimental data, ring artifact is mostly the primary cause. One single projection data set is used only in simulation and experiment. So the PAD approach can be applied to the quantitative information research of mixed contrast objects. In addition, because of the relatively low radiation dose, it should be suited to investigate the quantitative phase-contrast CT of biomedical sample with soft tissue and bone together.

Keywords:

phase-attenuation duality /
phase retrieval /
in-line X-ray phase contrast computed tomography

作者及机构信息

1.
中国科学院上海应用物理研究所, 上海 201800;

2.
中国科学院研究生院, 北京 100049

基金项目: 国家重点基础研究发展计划课题(批准号: 2010CB834301), 中国科学院对外合作重点项目(批准号: GJHZ09058), 国家自然科学基金(批准号: 10805071, 10705020)和上海市基础研究重点项目(批准号: 08JC1411900)资助的课题.

Authors and contacts

1.
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China;

2.
Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Funds: Project supported by the National Basic Research Program of China (Grant No. 2010CB834301), the External Cooperation Program of Chinese Academy of sciences (Grant No. GJHZ09058), the National Natural Science Foundation of China (Grant Nos. 10805071, 10705020), and the Key Basic Research Program of Shanghai, China (Grant No. 08Jc1411900).

参考文献

[1]	Chen R C, Xie H L, Du G H, Deng B, Zhu P P, Tong Y J, Wang Y D, Xiao T Q 2010 Acta Opt. Sin. 30 1106 [陈荣昌, 谢红兰, 杜国浩, 邓彪, 朱佩平, 佟亚军, 王玉丹, 肖体乔 2010 光学学报 textbf 30 1106]
[2]	Chen R C 2010 Ph. D. Thesis (Shanghai: Shanghai Institute of Applied Physics, Chinese Academy of Sciences) (in Chinese) [陈荣昌 2010 博士学位论文 (上海:中国科学院上海应用物理研究所)]
[3]
[4]	Xue Y L, Xiao T Q,Wu L H, Chen C, Guo R Y, Du G H, Xie H L, Deng B, Ren Y Q, Xu H J 2010 Acta Phys. Sin. 59 5496 [薛艳玲, 肖体乔, 吴立宏, 陈灿, 郭荣怡, 杜国浩, 谢红兰, 邓彪, 任玉琦, 徐洪杰 2010 物理学报 textbf 59 5496]
[5]
[6]
[7]	Chen R C, Longo R, Rigon L, Zanconati F, Pellegrin A De, Arfelli F, Dreossi D, Menk R H, Vallazza E, Xiao T Q, Castelli E 2010 Phys. Med. Biol. 55 4993
[8]	Zhou G Z, Tong Y J, Chen C, Ren Y Q,Wang Y D, Xiao T Q 2011 Acta Phys. Sin. 60 028071 [周光照, 佟亚军, 陈灿, 任玉琦, 王玉丹, 肖体乔 2011 物理学报 textbf 60 028071]
[9]
[10]
[11]	Chen R C, Xie H L, Rigon L, Longo R, Castelli E, Xiao T Q 2011 Opt. Lett. 36 1719
[12]
[13]	Yuqi Ren, Can Chen, Rongchang Chen, Guangzhao Zhou, Yudan Wang, Tiqiao Xiao 2011 Opt. Express. 19 4170
[14]
[15]	Su X Y, Li J T 1999 Information Optics (1st Edition) (Beijing: Science Press) p3446 (in Chinese) [苏显渝, 李继陶 1999 信息光学 (第一版) (北京: 科学出版) 第3446页]
[16]	Hsieh J 2006 Computed Tomography: Principle, Design, Artifacts and Recent Advances (1st Edition) (Beijing: Science Press) p27 50 (in Chinese) [ 谢强 2006 计算机断层成像技术: 原理、设计、伪像和进展 (第一版) (北京: 科学出版社) 第2750页]
[17]
[18]
[19]	Wu X Z, Liu H, Yan A M 2008 EJR 68S S8
[20]	Wu X Z, Liu H, Yan A M 2005 Opt. Lett. 30 379
[21]
[22]
[23]	Guigay J P, Langer M, Boistel R, Cloetens P 2007 Opt. Lett. 32 1617
[24]
[25]	Wu X Z, Yan A M 2009 Opt. Express. 17 11187
[26]	Groso A, Stampanoni M, Abela R, Schneider P, Linga S, Muller R 2006 Appl. Phys. Lett. 88 214014
[27]
[28]	Langer M, Cloetens P, Guigay J P, Peyrin F 2008 Am. Assoc. Phys. Med. 35 4556
[29]
[30]
[31]	Zabler S, Cloetens P, Guigay J P, Baruchel J 2005 Rev. Sci. Instrum. 76 073705
[32]
[33]	Langer M, Cloetens P, Peyrin F 2009 J. Opt. Soc. Am. A 26 1876
[34]	Cloetens P, Mache R, Schlenker M, Mache S L 2006 PNAS 103 14626
[35]
[36]	Langer M, Peyrin F 2010 IEEE 19 2428
[37]
[38]
[39]	Groso A, Abela R, Stampanoni M 2006 Opt. Express 14 8103

施引文献

[1]	Chen R C, Xie H L, Du G H, Deng B, Zhu P P, Tong Y J, Wang Y D, Xiao T Q 2010 Acta Opt. Sin. 30 1106 [陈荣昌, 谢红兰, 杜国浩, 邓彪, 朱佩平, 佟亚军, 王玉丹, 肖体乔 2010 光学学报 textbf 30 1106]
[2]	Chen R C 2010 Ph. D. Thesis (Shanghai: Shanghai Institute of Applied Physics, Chinese Academy of Sciences) (in Chinese) [陈荣昌 2010 博士学位论文 (上海:中国科学院上海应用物理研究所)]
[3]
[4]	Xue Y L, Xiao T Q,Wu L H, Chen C, Guo R Y, Du G H, Xie H L, Deng B, Ren Y Q, Xu H J 2010 Acta Phys. Sin. 59 5496 [薛艳玲, 肖体乔, 吴立宏, 陈灿, 郭荣怡, 杜国浩, 谢红兰, 邓彪, 任玉琦, 徐洪杰 2010 物理学报 textbf 59 5496]
[5]
[6]
[7]	Chen R C, Longo R, Rigon L, Zanconati F, Pellegrin A De, Arfelli F, Dreossi D, Menk R H, Vallazza E, Xiao T Q, Castelli E 2010 Phys. Med. Biol. 55 4993
[8]	Zhou G Z, Tong Y J, Chen C, Ren Y Q,Wang Y D, Xiao T Q 2011 Acta Phys. Sin. 60 028071 [周光照, 佟亚军, 陈灿, 任玉琦, 王玉丹, 肖体乔 2011 物理学报 textbf 60 028071]
[9]
[10]
[11]	Chen R C, Xie H L, Rigon L, Longo R, Castelli E, Xiao T Q 2011 Opt. Lett. 36 1719
[12]
[13]	Yuqi Ren, Can Chen, Rongchang Chen, Guangzhao Zhou, Yudan Wang, Tiqiao Xiao 2011 Opt. Express. 19 4170
[14]
[15]	Su X Y, Li J T 1999 Information Optics (1st Edition) (Beijing: Science Press) p3446 (in Chinese) [苏显渝, 李继陶 1999 信息光学 (第一版) (北京: 科学出版) 第3446页]
[16]	Hsieh J 2006 Computed Tomography: Principle, Design, Artifacts and Recent Advances (1st Edition) (Beijing: Science Press) p27 50 (in Chinese) [ 谢强 2006 计算机断层成像技术: 原理、设计、伪像和进展 (第一版) (北京: 科学出版社) 第2750页]
[17]
[18]
[19]	Wu X Z, Liu H, Yan A M 2008 EJR 68S S8
[20]	Wu X Z, Liu H, Yan A M 2005 Opt. Lett. 30 379
[21]
[22]
[23]	Guigay J P, Langer M, Boistel R, Cloetens P 2007 Opt. Lett. 32 1617
[24]
[25]	Wu X Z, Yan A M 2009 Opt. Express. 17 11187
[26]	Groso A, Stampanoni M, Abela R, Schneider P, Linga S, Muller R 2006 Appl. Phys. Lett. 88 214014
[27]
[28]	Langer M, Cloetens P, Guigay J P, Peyrin F 2008 Am. Assoc. Phys. Med. 35 4556
[29]
[30]
[31]	Zabler S, Cloetens P, Guigay J P, Baruchel J 2005 Rev. Sci. Instrum. 76 073705
[32]
[33]	Langer M, Cloetens P, Peyrin F 2009 J. Opt. Soc. Am. A 26 1876
[34]	Cloetens P, Mache R, Schlenker M, Mache S L 2006 PNAS 103 14626
[35]
[36]	Langer M, Peyrin F 2010 IEEE 19 2428
[37]
[38]
[39]	Groso A, Abela R, Stampanoni M 2006 Opt. Express 14 8103

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