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荧光显微镜研究极端pH值诱导磷脂支撑膜的侧向再组织

盛洁 张国梁 李玉强 朱涛 蒋中英

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荧光显微镜研究极端pH值诱导磷脂支撑膜的侧向再组织

盛洁, 张国梁, 李玉强, 朱涛, 蒋中英

Extreme pH-induced lateral reorganization of supported lipid bilayer by fluorescence microscope

Sheng Jie, Zhang Guo-Liang, Li Yu-Qiang, Zhu Tao, Jiang Zhong-Ying
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  • 利用荧光显微镜研究了极端pH值诱导支撑磷脂双层膜的侧向再组织. 结果表明,在强酸/强碱性溶液中,流动性较好的二油酰磷脂酰胆碱支撑膜出现破裂、分离、出芽或生出微管等与细胞内吞和外排相似的现象. 基于极性分子与H+/H3O+或OH-的相互作用,以电中性的磷脂首基为核吸附溶液中的H+/H3O+或OH-. 当磷脂膜上下叶吸附的电荷量不同时,引起两叶有效面积差,即磷脂膜曲率不对称,从而诱发磷脂膜出现各种结构和动力学的响应. 本研究有助于理解极端环境对生物膜的影响,为研究生物膜的形变过程提供了参考.
    The extreme pH-induced lateral reorganization of supported lipid bilayer membranes are studied by fluorescence microscopy. The results show that the fluid dioleoyl-phosphatidylcholine bilayers in extreme acidic or basic solution presents a similar phenomenon to endocytosis and exocytosis, such as rupture, detachment, budding, formation of microtubules etc. In the view of the interaction of polar molecules with H+/H3O+ or OH ions, we conclude that the zwitterionic phospholipid headgroup as core adsorbs the H+/H3O+ or OH ions in electrolyte solution. The asymmetric charge adsorption quantity of the lipid headgroups leads to the effective area discrepancy between the outer and inner leaflets of lipid bilayers. The asymmetric membrane curvatures induce a variety of structures and dynamic responses. The present study helps explain lipid membranes reorganization under extreme pH conditions and provides some guidelines for deformation process of lipid membranes.
    • 基金项目: 国家重点基础研究发展计划(批准号:2012CB821500)和国家自然科学基金(批准号:21264016,21364016)资助的课题.
    • Funds: Project supported by the National Basic Research Program of China (Grant No. 2012CB821500) and the National Natural Science Foundation of China (Grant Nos. 21264016, 21364016).
    [1]

    Suresh S, Edwardson J M 2010 Biochem. Bioph. Res. Co. 399 571

    [2]

    Li L, Liang X Y, Lin M Y, Qiu F, Yang Y L 2005 JACS 127 17996

    [3]

    Li R T, Xie L, Zhu Z S, Liu Q, Hu Y, Jiang X Q, Yu L X, Qian X P, Guo W H, Ding Y T, Liu B R 2011 PLoS One 6 24172

    [4]

    Li D X, He Q, Cui Y, Li J B 2007 Chem. Mater. 19 412

    [5]

    Yang K, Ma Y Q 2012 Soft Matter 8 606

    [6]

    Zhou X H, Zhang S G, Yang J Q, Qu X M, Liu Y S, Wang S G 2007 Acta Phys. Sin. 56 6137 (in Chinese) [周晓华, 张劭光, 杨继庆, 屈学民, 刘渊声, 王斯刚 2007 物理学报 56 6137]

    [7]

    Xie Y Z, Liu J X, Ouyang Z C 2002 Elastic Theory of Surfaces of Biomembrane-Vesicle (Shanghai: Shanghai Scientific and Technical Publishers) p87 (in Chinese) [谢毓章, 刘寄星, 欧阳钟灿 2002 生物膜泡曲面弹性理论 (上海: 上海科学技术出版社) 第87 页]

    [8]

    Xia B K, Li J F, Li W H, Zhang H D, Qiu F 2013 Acta Phys. Sin. 62 248701 (in Chinese) [夏彬凯, 李剑锋, 李卫华, 张红东, 邱枫 2013 物理学报 62 248701]

    [9]

    Bandekar A, Sofou S 2012 Langmuir 28 4113

    [10]

    Goertz M P, Goyal N, Montano G A, Bunker B C 2011 Langmuir 27 5481

    [11]

    Liu X H, Huang W M, Wang E K 2005 J. Electroanal. Chem. 577 349

    [12]

    Jiang Z Y, Zhang G L, Ma J, Zhu T 2013 Acta Phys. Sin. 62 018701 (in Chinese) [蒋中英, 张国梁, 马晶, 朱涛 2013 物理学报 62 018701]

    [13]

    Yamazaki V, Sirenko O, Schafer R J, Groves J T 2005 JACS 127 2826

    [14]

    Zhang J A A, Pawelchak J 2000 Eur. J. Pharm. Biopharm. 50 357

    [15]

    Wang B, Zhang L F, Bae S C, Granick S 2008 PNAS 105 18171

    [16]

    Garcia-Manyes S, Oncins G, Sanz F 2006 Electrochim. Acta 51 5029

    [17]

    Wang C Y, Tao Y 1993 Glass Surface and Surface Treatment (Beijing: China Building Materials Press) p123 (in Chinese) [王承遇, 陶瑛 1993 玻璃表面和表面处理 (北京: 中国建材工业出版社) 第123页]

    [18]

    Liang X Y 2007 Ph. D. Dissertation (Shanghai: Fudan University) (in Chinese) [梁新宇2007 博士学位论文 (上海: 复旦大学)]

    [19]

    Vacha R, Siu S W I, Petrov M, Bockmann R A, Barucha-Kraszewska J, Jurkiewicz P, Hof M, Berkowitz, M L, Jungwirth P 2009 J. Phys. Chem. A 113 7235

  • [1]

    Suresh S, Edwardson J M 2010 Biochem. Bioph. Res. Co. 399 571

    [2]

    Li L, Liang X Y, Lin M Y, Qiu F, Yang Y L 2005 JACS 127 17996

    [3]

    Li R T, Xie L, Zhu Z S, Liu Q, Hu Y, Jiang X Q, Yu L X, Qian X P, Guo W H, Ding Y T, Liu B R 2011 PLoS One 6 24172

    [4]

    Li D X, He Q, Cui Y, Li J B 2007 Chem. Mater. 19 412

    [5]

    Yang K, Ma Y Q 2012 Soft Matter 8 606

    [6]

    Zhou X H, Zhang S G, Yang J Q, Qu X M, Liu Y S, Wang S G 2007 Acta Phys. Sin. 56 6137 (in Chinese) [周晓华, 张劭光, 杨继庆, 屈学民, 刘渊声, 王斯刚 2007 物理学报 56 6137]

    [7]

    Xie Y Z, Liu J X, Ouyang Z C 2002 Elastic Theory of Surfaces of Biomembrane-Vesicle (Shanghai: Shanghai Scientific and Technical Publishers) p87 (in Chinese) [谢毓章, 刘寄星, 欧阳钟灿 2002 生物膜泡曲面弹性理论 (上海: 上海科学技术出版社) 第87 页]

    [8]

    Xia B K, Li J F, Li W H, Zhang H D, Qiu F 2013 Acta Phys. Sin. 62 248701 (in Chinese) [夏彬凯, 李剑锋, 李卫华, 张红东, 邱枫 2013 物理学报 62 248701]

    [9]

    Bandekar A, Sofou S 2012 Langmuir 28 4113

    [10]

    Goertz M P, Goyal N, Montano G A, Bunker B C 2011 Langmuir 27 5481

    [11]

    Liu X H, Huang W M, Wang E K 2005 J. Electroanal. Chem. 577 349

    [12]

    Jiang Z Y, Zhang G L, Ma J, Zhu T 2013 Acta Phys. Sin. 62 018701 (in Chinese) [蒋中英, 张国梁, 马晶, 朱涛 2013 物理学报 62 018701]

    [13]

    Yamazaki V, Sirenko O, Schafer R J, Groves J T 2005 JACS 127 2826

    [14]

    Zhang J A A, Pawelchak J 2000 Eur. J. Pharm. Biopharm. 50 357

    [15]

    Wang B, Zhang L F, Bae S C, Granick S 2008 PNAS 105 18171

    [16]

    Garcia-Manyes S, Oncins G, Sanz F 2006 Electrochim. Acta 51 5029

    [17]

    Wang C Y, Tao Y 1993 Glass Surface and Surface Treatment (Beijing: China Building Materials Press) p123 (in Chinese) [王承遇, 陶瑛 1993 玻璃表面和表面处理 (北京: 中国建材工业出版社) 第123页]

    [18]

    Liang X Y 2007 Ph. D. Dissertation (Shanghai: Fudan University) (in Chinese) [梁新宇2007 博士学位论文 (上海: 复旦大学)]

    [19]

    Vacha R, Siu S W I, Petrov M, Bockmann R A, Barucha-Kraszewska J, Jurkiewicz P, Hof M, Berkowitz, M L, Jungwirth P 2009 J. Phys. Chem. A 113 7235

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  • 被引次数: 0
出版历程
  • 收稿日期:  2013-10-23
  • 修回日期:  2013-12-09
  • 刊出日期:  2014-03-05

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