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一类自突触作用下神经元电路的设计和模拟

任国栋 武刚 马军 陈旸

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一类自突触作用下神经元电路的设计和模拟

任国栋, 武刚, 马军, 陈旸

Simulation of electric activity of neuron by setting up a reliable neuronal circuit driven by electric autapse

Ren Guo-Dong, Wu Gang, Ma Jun, Chen Yang
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  • 神经元在自突触作用下可以诱发各类放电活动的迁移, 神经元动作电位对电自突触的响应比较敏感. 通常用包含延迟因子和增益的反馈回路电流来刻画自突触对神经元动作电位的影响. 基于Pspice软件, 设计了包含自突触效应的神经元电路, 用以延迟反馈电路来模拟电自突触对电位的调制作用. 研究结果发现: 1)在外界刺激和电自突触回路协同作用下, 神经元电路输出信号可以呈现静息态, 尖峰放电, 簇放电状态. 2)在时变增大的外界刺激下和自突触回路驱动下, 神经元电路的输出电位序列在多种电活动模式之间(静息, 尖峰放电, 簇放电)交替出现, 其机理在于自突触回路具有记忆特性, 神经元对于不同的外界刺激可以做出不同模式的响应. 3)在给定比较大外界刺激下, 改变反馈回路的增益, 发现电路输出的序列也可以呈现不同模式交替, 即神经元对于相同的刺激可以通过自我调节自突触增益来产生不同模式的响应, 其机理可能在于回路的有效反馈, 这有助于理解突触的可塑性.
    Transition of electric activity of neuron can be induced by electric autapse, and its action potential is much sensitive to the stimuli from the electric autapse. Generally, the effect of electric autapse on membrane potential of neuron is often described by using time-delayed feedback in closed loop. Based on Pspice software, a class of electric circuit is designed with the electric autapse being taken into consideration, and a time-delayed circuit is used to detect the adjusting action of electric autapse on the action potential. Results are found as follows: (1) The neuronal electric circuit can produce quiescent state, spiking, bursting state under an external force besides the electric autapse circuit. (2) The transition of electric activity occurs between four different atates (quiescent, spiking, bursting state) by imposing a time-varying forcing current; its potential mechanism is that the electric circuit is associated with the memory, and the neuron can give different types of response to the same external forcing current. (3)When a strong external force is imposed, the outputs can show different type of electric activities due to an electric autapse, that is to say, self-adaption of gain in the autapse is useful for the neuron and thus different type of electric activities occurs, whose potential mechanism may be due to the effective feedback in the loop; so it is helpful to understand the synaptic plasticity.
    • 基金项目: 国家自然科学基金(批准号: 11265008, 11372122)资助的课题.
    • Funds: Project supported by the National Nautral Science of Foundation of China (Grant Nos. 11265008, 11372122).
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    Sanjuán M A F, Ibarz B, Casado J M 2011 Phys. Rep. 501 1

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    Gu H G 2013 Chaos 23 023126

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    Kunichika T, Hiroyuki K, Tetsuya Y, Aiharad K, Kawakamif H 2006 Neurocomput. 69 293

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    Yang Z Q, Lu Q S 2008 Sci. China Ser. Phys. Mech. Astron. 51 687

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    [40]

    Wagemakers A, Sanjuán A F, Casado J M 2006 Int. J. Bifurcat. Chaos 16 3617

    [41]

    Dahasert N, Ozturk I, Kilic R 2012 Nonlinear Dyn. 70 2343

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    Rabinovich M, Huerta R, Bazhenov M, Kozlov A K, Abarbanel H D I 1998 Phys. Rev. E 58 6418

    [43]

    Mayer J, Schuster H G, Claussen J C 2006 Phys. Rev E. 73 031908

    [44]

    Li F, Liu Q R, Guo H Y et al. 2012 Nonlinear Dyn. 69 2169

    [45]

    Nowotny T, Rabinovich M I 2007 Phys. Rev. Lett. 98 128106

    [46]

    Sitt J D, Aliaga J 2007 Phys. Rev. E 76 051919

    [47]

    Kwon O, Kim K, Park S, Moon H T 2011 Phys. Rev. E 84 021911

    [48]

    Ayers J, Rulkov N, Knudsen D, Kim Y B, Volkovskii A, Selverston A 2010 Appl. Bionics. Biom. 7 57

    [49]

    Lee Y J, Lee J, Kim K K, Kim Y B, Ayers J 2007 Neurocomput . 71 284

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    Bekkers J M 2003 Curr. Biol. 13 R433

    [51]

    Bekkers J M 2002 Curr. Biol. 12 R648

    [52]

    Bekkers J M 2009 Curr. Biol. 19 R296

    [53]

    Herrmann C S, Klaus A 2004 Int. J. Bifurcat. Chaos 14 623

    [54]

    Wang H T, Ma J, Chen Y L, Chen Y 2014 Commun. Nonlinear Sci. Numer. Simulat. 19 3242

    [55]

    Qin H X, Ma J, Jin W Y, Wang C N 2014 Sci. China Tech. Sci. 57 936

    [56]

    Chen J, Li C G 2011 Acta Phys. Sin. 60 050503 (in Chinese) [陈军, 李春光 2011 物理学报 60 050503]

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    L Y Y, Schmid G, Hänggi P, Schimansky-Geier L 2010 Phys. Rev. E 82 061907

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    Ma J, Ying H P, Liu Y, Li S R 2009 Chin. Phys. B 18 98

  • [1]

    Hodgkin A L, Huxley A F 1952 J. Physiol. 117 500

    [2]

    Rinzel J, Ermentrout G B 1989 Analysis of neuronal excitability and oscillations, C Koch and I. Segev (Eds.), Methods in neuronal Modeling: from synapses to Networks (MIT press, London)

    [3]

    Cronin J 1987 Mathematical Aspects of Hodgkin-Huxley Neural Theory (Cambridage University Press, Cambridge, UK)

    [4]

    Morris C, Lecar H 1981 Biophys. J. 35 193

    [5]

    Smith G D 2002 Comput. Cell Biol. 20 285

    [6]

    Sanjuán M A F, Ibarz B, Casado J M 2011 Phys. Rep. 501 1

    [7]

    Hindmarsh J L, Rose R M 1982 Nature 296 162

    [8]

    Hindmarsh J L, Rose R M 1984 Proc. R. Soc. Lond. B 221 87

    [9]

    Gu H G 2013 Chaos 23 023126

    [10]

    Kunichika T, Hiroyuki K, Tetsuya Y, Aiharad K, Kawakamif H 2006 Neurocomput. 69 293

    [11]

    Shilnikov A 2012 Nonlinear Dyn. 68 305

    [12]

    Yang Z Q, Lu Q S 2008 Sci. China Ser. Phys. Mech. Astron. 51 687

    [13]

    Crotti P 2011 Analysis of coherence resonance near bifurcation points in the stochastic Class II Morris-Lecar model. Master thesis (University of Fribourg Switzerland)

    [14]

    Selverston A I, Rabinovich M I, Abarbanel H D I Elson R, Szcs A, Pinto R D, Huerta R, Varona P 2000 J. Physiol. (Paris) 94 357

    [15]

    Wang W, Chen G, Wang Z D 1997 Phys. Rev. E 56 3728

    [16]

    Wei D Q, Luo X S 2007 Commun. Theor. Phys. 48 759

    [17]

    Perc M 2007 Phys. Rev. E 76 066203

    [18]

    Perc M, Gosak M 2008 New J. Phys. 10 053008

    [19]

    Gosak M, Marhl M, Perc M 2009 Physica D 238 506

    [20]

    Kwon O, Jo H H, Moon H T 2005 Phys. Rev. E 72 066121

    [21]

    Yuan W J, Luo X S, Yang R H 2007 Chin. Phys. Lett. 24 835

    [22]

    Perc M 2009 Eur. Phys. J. B 69 147

    [23]

    Chik D T W, Wang Y Q, Wang Z D 2001 Phys. Rev. E 64 021913

    [24]

    Yu Y G, Wang W, Wang J F, Liu F 2001 Phys. Rev. E 63 021907

    [25]

    Zhang J Q, Wang C D, Wang M S, Huang S F 2011 Nerocomput. 74 2961

    [26]

    Gu H G, Jia B, Li Y Y, Chen G R 2013 Physica A 392 1361

    [27]

    Wang Q Y, Zheng Y H, Ma J 2013 Chaos Solitons & Fractals 56 19

    [28]

    Ma J, Wu Y, Wu N J, Guo H Y 2013 Sci. China Phys. .Mech. Astro. 56 952

    [29]

    H B L, Ma J, Tang J 2013 Plos One 8 69251

    [30]

    Li Y Y, Jia B, Gu H G 2012 Acta Phys. Sin. 61 070504 (in Chinese) [李玉叶, 贾冰, 古华光 2012 物理学报 61 070504]

    [31]

    Tang Z, Li Y Y, Xi L, Jia B, Gu H G 2012 Commun. Theor. Phys. 57 61

    [32]

    Liu S B, Wu Y, Li J J, Xie Y, Tan N 2013 Nonlinear. Dyn. 73 1055

    [33]

    Wu Y, Li J J, Liu S B, Pan J Z, Du M M, Lin P 2013 Cogn. Neurodyn. 7 431

    [34]

    Gu H G 2013 Plos One 8 81759

    [35]

    Gu H G, Pan B B, Xu J 2014 EPL 106 50003

    [36]

    Gu H G, Jia B, Chen G R 2013 Phys. Lett. A 377 718

    [37]

    Jia B, Gu H G 2012 Acta Phys. Sin. 61 240505 (in Chinese) [贾冰, 古华光 2012 物理学报 61 240505]

    [38]

    Knudsen Daniel P 2006 Creating functional neural control circuits incorporating both discrete-time, map based neuron and Hindmarsh-Rose electronic neurons (Honors Junior/Senior Projects) Paper 11

    [39]

    Wu X Y, Ma J, Yuan L H, Liu Y 2014 Nonlinear Dyn. 75 113

    [40]

    Wagemakers A, Sanjuán A F, Casado J M 2006 Int. J. Bifurcat. Chaos 16 3617

    [41]

    Dahasert N, Ozturk I, Kilic R 2012 Nonlinear Dyn. 70 2343

    [42]

    Rabinovich M, Huerta R, Bazhenov M, Kozlov A K, Abarbanel H D I 1998 Phys. Rev. E 58 6418

    [43]

    Mayer J, Schuster H G, Claussen J C 2006 Phys. Rev E. 73 031908

    [44]

    Li F, Liu Q R, Guo H Y et al. 2012 Nonlinear Dyn. 69 2169

    [45]

    Nowotny T, Rabinovich M I 2007 Phys. Rev. Lett. 98 128106

    [46]

    Sitt J D, Aliaga J 2007 Phys. Rev. E 76 051919

    [47]

    Kwon O, Kim K, Park S, Moon H T 2011 Phys. Rev. E 84 021911

    [48]

    Ayers J, Rulkov N, Knudsen D, Kim Y B, Volkovskii A, Selverston A 2010 Appl. Bionics. Biom. 7 57

    [49]

    Lee Y J, Lee J, Kim K K, Kim Y B, Ayers J 2007 Neurocomput . 71 284

    [50]

    Bekkers J M 2003 Curr. Biol. 13 R433

    [51]

    Bekkers J M 2002 Curr. Biol. 12 R648

    [52]

    Bekkers J M 2009 Curr. Biol. 19 R296

    [53]

    Herrmann C S, Klaus A 2004 Int. J. Bifurcat. Chaos 14 623

    [54]

    Wang H T, Ma J, Chen Y L, Chen Y 2014 Commun. Nonlinear Sci. Numer. Simulat. 19 3242

    [55]

    Qin H X, Ma J, Jin W Y, Wang C N 2014 Sci. China Tech. Sci. 57 936

    [56]

    Chen J, Li C G 2011 Acta Phys. Sin. 60 050503 (in Chinese) [陈军, 李春光 2011 物理学报 60 050503]

    [57]

    L Y Y, Schmid G, Hänggi P, Schimansky-Geier L 2010 Phys. Rev. E 82 061907

    [58]

    Ma J, Ying H P, Liu Y, Li S R 2009 Chin. Phys. B 18 98

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出版历程
  • 收稿日期:  2014-06-20
  • 修回日期:  2014-09-30
  • 刊出日期:  2015-03-05

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