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单个心肌细胞中随机钙火花诱发的钙离子螺旋波

白永强 朱星

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单个心肌细胞中随机钙火花诱发的钙离子螺旋波

白永强, 朱星

Calcium ion spiral wave induced by random calcium ion sparks in single heart cell

Bai Yong-Qiang, Zhu Xing
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  • 利用改进的描述单个心肌细胞内钙信号的离散的fire-diffuse-fire模型和相分析方法, 模拟研究了钙火花随机释放特性对钙离子螺旋波的诱导激发作用, 研究结果表明, 适当频率的钙火花可以在静息心肌细胞中诱导产生钙离子螺旋波; 时序和空间不同的钙火花引起的相奇点的出现, 是产生螺旋波的关键; 系统相奇点的个数与钙火花频率相关, 并且对于固定系统有极限值.
    Calcium ion spiral wave induced by random released calcium ion sparks in single heart cell is studied using the improved discrete fire-diffuse-fire model and phase analysis method. The results show that calcium ion spiral wave can be excited in resting heart cell by calcium ion sparks at an appropriate release frequency. The key of the generation of calcium ion spiral wave is the emergence of the phase singularity caused by the calcium sparks in the different time and space sequences. The number of phase singularity is exponentially linked with calcium ion spark frequency, and has the limit in a fixed system.
    • 基金项目: 黑龙江省自然科学基金(批准号: A200911)和国家重点基础研究发展计划(973计划)(批准号: 2007CB936800)资助的课题.
    • Funds: Project supported by the Natural Science Foundation of Heilongjiang Province, China (Grant No. A200911), and the National Basic Research Program of China (Grant No. 2007CB936800).
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    Coombes S, Timofeeva Y 2003 Phys. Rev. E 68 021915

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    Bai Y Q, Zhu X 2010 Chin. Phys. Lett. 27 048201

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    Gray R A, Pertsov A M, Jalife J 1998 Nature 392 75

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    Iyer A N, Gray R A 2001 Ann. Biomed. Eng. 29 47

    [15]

    Falcke M, Tsimring L, Levine H 2000 Phys. Rev. E 62 2636

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    Bai Y, Tang A, Wang S, Zhu X 2008 J. Microsc. 229 555

    [17]

    Tang A H, Wang S Q 2009 Chaos 19 037114

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    Gotoh M, Uchida T, Mandel W J, Fishbein M C, Chen P S, Karagueuzian H S 1997 Circulation 95 2141

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    Marée A F M, Panfilov A V 1997 Phys. Rev. Lett. 78 1819

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    Tang D N, Tang G N 2010 Acta Phys. Sin. 59 2319 (in Chinese) [唐冬妮, 唐国宁 2010 物理学报 59 2319]

    [21]

    Qiu K, Tang J, Ma J, Luo J M 2010 Chin. Phys. B 19 030508

  • [1]

    Clapham D E 1995 Cell 80 259

    [2]

    Berridge M J, Lipp P, Bootman M D 2000 Nat. Rev. Mol. Cell Biol. 1 11

    [3]

    Carafoli E, Santella L, Brance D, Brini M 2001 Crit. Rev. Biochem. Mol. Biol. 36 107

    [4]

    Berridge M J, Bootman M D, Llewelyn Roderick H 2003 Nat. Rev. Mol. Cell Biol. 4 517

    [5]

    Bers D M 2002 Nature 415 198

    [6]

    Cheng H, Lederer W J, Cannell M B 1993 Science 262 740

    [7]

    Cheng H, Lederer M R, Lederer W J, Cannell M B 1996 Am. J. Physiol. 270 C148

    [8]

    Lukyanenko V, Györke S 1999 J. Physiol. 521 575

    [9]

    Bjornstad O N, Peltonen M, Liebhold A M, Baltensweiler W 2002 Science 298 1020

    [10]

    Keizer J, Smith G D 1998 Biophys. Chem. 72 87

    [11]

    Coombes S, Timofeeva Y 2003 Phys. Rev. E 68 021915

    [12]

    Bai Y Q, Zhu X 2010 Chin. Phys. Lett. 27 048201

    [13]

    Gray R A, Pertsov A M, Jalife J 1998 Nature 392 75

    [14]

    Iyer A N, Gray R A 2001 Ann. Biomed. Eng. 29 47

    [15]

    Falcke M, Tsimring L, Levine H 2000 Phys. Rev. E 62 2636

    [16]

    Bai Y, Tang A, Wang S, Zhu X 2008 J. Microsc. 229 555

    [17]

    Tang A H, Wang S Q 2009 Chaos 19 037114

    [18]

    Gotoh M, Uchida T, Mandel W J, Fishbein M C, Chen P S, Karagueuzian H S 1997 Circulation 95 2141

    [19]

    Marée A F M, Panfilov A V 1997 Phys. Rev. Lett. 78 1819

    [20]

    Tang D N, Tang G N 2010 Acta Phys. Sin. 59 2319 (in Chinese) [唐冬妮, 唐国宁 2010 物理学报 59 2319]

    [21]

    Qiu K, Tang J, Ma J, Luo J M 2010 Chin. Phys. B 19 030508

计量
  • 文章访问数:  6222
  • PDF下载量:  356
  • 被引次数: 0
出版历程
  • 收稿日期:  2012-03-19
  • 修回日期:  2012-05-24
  • 刊出日期:  2012-08-05

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