Decoding the neural activity of dorsal spinal nerve root evoked by acupuncture at Zusanli point based on the generalized linear model

Xue Ming; Wang Jiang; Deng Bin; Wei Xi-Le; Chen Ying-Yuan

doi:10.7498/aps.62.098701

Abstract

Neural system can characterize the information evoked in external stimulations by spatiotemporal encoding. Acupunctureas, as a mechanical actionis equivalent to an external stimulus to the neural system. In order to decipher how neural systems represent and transmit acupuncture information, experiments are designed such that different frequencies of manual acupuncture (MA) manipulations can be given to ‘Zusanli’ point of an experimental rat, and the induced electrical signals in spinal dorsal root ganglion are detected and recorded. First, the spike trains are obtained by data preprocessing and transformed into point process trains. Then a generalized linear model is introduced to encode the acupuncture information and produce the simulated neural spike train. In addition, a Bayesian decoding algorithm is used to reconstruct the displacement oscillograms of the acupuncture needle from the neural point process spike train. Finally, the quantile-quantile (Q-Q) plot based on the time-rescaling theorem is used to evaluate the agreement between the encoding model and the point process data. Results prove to be valid based on statistical analysis. These studies have offered new insights into neural processing underlying acupuncture and have implementations for constructing the interface between neural systems and machines and improving the clinical study.

Keywords:

Authors and contacts

1.
School of Electrical and Automation Eng., Tianjin University, Tianjin 300072, China
Funds: Project supported by the Key Program of the National Natural Science Foundation of China (Grant No. 50537030), the National Natural Science Foundation of China(Grant Nos. 61072012, 61172009), the Young Scientists Fund of the National Natural Science Foundation of China (Grant Nos. 50907044, 60901035, 61104032) and the China Postdoctoral Science Foundation (Grant No. 2012M510750).

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Cited By

[1]	Andersson S, Lundeberg T 1995 Med. Hypotheses 45 271
[2]	VanderPloeg K, Yi X 2009 J. Acupunct. Meridian Stud. 2 26
[3]	Leake R, Broderick J E 1999 Integr. Med. 1 107
[4]	Foster J M, Sweeney B P 1987 Br. J. Hosp. Med. 38 308
[5]	Cho Z H, Chung S C, Jones J P, Park J B, Park H J, Lee H J, Wong E K, Min B I 1998 Proc. Natl. Acad. Sci. USA 95 2670
[6]	Zhang Y, Qin W, Liu P, Tian J, Liang J M, Karen V D, Liu Y J 2009 Neurosci. Lett. 449 6
[7]	Zhang W T, Jin Z, Cui G H 2003 Brain Res. 982 168
[8]	Wang T T, Yuan Y, Kang Y, Yuan W L, Zhang H T, Wu L Y, Feng Z T 2005 Neurosci. Lett. 382 236
[9]	Han J S 2003 Trends Neurosci. 26 17
[10]	Backer M, Hammes M G, Valet M, Deppe M, Conrad B, Tolle T R, Dobos G 2002 Neurosci. Lett. 333 203
[11]	Cui Y M, Qi L J 1998 International Journal of Clinical Acupuncture 9 317
[12]	Cai W Y 1992 American Journal of Chinese Medicine 20 331
[13]	Han C X, Wang J, Che Y Q, Deng B, Guo Y, Guo Y M, Liu Y Y 2010 Acta Phys. Sin. 59 5880 (in Chinese) [韩春晓, 王江, 车艳秋, 邓斌, 郭义, 郭永明, 刘阳阳 2010 物理学报 59 5880]
[14]	Takeshige C, Oka K, Mizuno T, Hisamitsu T, Luo C P, Kobori M, Mera H, Fang T Q 1993 Brain Res. Bull. 30 53
[15]	Squire L, Berg D, Bloem F, Lac S D, Ghosh A, Spitzer N 2009 Sensory system and motor system (Beijing: Science Press)
[16]	Wang J, Sun L, Fei X, Zhu B 2007 Chaos Solitons Fract. 33 901
[17]	Men C, Wang J, Qin Y M, Deng B, Wei X L 2011 Computer Methods and Programs in Biomedicine 104 498
[18]	Men C, Wang J, Deng B, Wei X L, Che Y Q, Han C X 2012 Neurocomputing 79 12
[19]	Men C, Wang J, Qin Y M, Tsang K M, Deng B 2011 Applied Mathematical Modelling 36 4742
[20]	Luo X L, Wang J, Han C X, Deng B, Wei X L, Bian H R 2012 Chin. Phys. B 21 028701
[21]	Bian H R, Wang J, Han C X, Deng B, Wei X L, Che Y Q 2011 Acta Phys. Sin. 60 118701 (in Chinese) [边洪瑞, 王江, 韩春晓, 邓斌, 魏熙乐, 车艳秋 2011 物理学报 60 118701]
[22]	Yi G S, Wang J, Deng B, Wei X L, Han C X 2012 Chin. Phys. B 028703
[23]	Yang Z Q, Lu Q S 2006 Chin. Phys. 15 578
[24]	Lu Q S, Wang H X, Wang Q Y 2005 Chin. Phys. 14 2189
[25]	Duan Y B, Hu S J, Xie Y, Xu J X, Kang Y M 2004 Chin. Phys. 13 1396
[26]	He G G, Zhu P, Chen H P, Xie X P 2010 Acta Phys. Sin. 59 5307 (in Chinese) [何国光, 朱萍, 陈宏平, 谢小平 2010 物理学报 59 5307]
[27]	Zhang H, Fang L P, Tong Q Y 2007 Acta Phys. Sin. 56 7339 [张宏, 方路平, 童勤业 2007 物理学报 56 7339]
[28]	Yu W Q, Xu D, Liu F, Wang W, Li J 2009 Chin. Phys. B 18 5560
[29]	Zhan Y, Zhang S H, Zhao T J, An H L, Zhang Z D, Han Y R, Liu H, Zhang Y H 2008 Chin. Phys. B 17 2297
[30]	Koyama S, Eden U T, Brown E N, Kass R E 2010 Annals of the Institute of Statistical Mathematics 62 37
[31]	Rieke F, Warland D, de Ruyter van Steveninck R, Bialek W 1997 Spikes: Exploring the neural code (Cambridge: The MIT Press)
[32]	Daley D J, Vere-Jones D 2003 An introduction to the theory of point processes (New York: Springer)
[33]	Liu T Y, Yang H Y, Ku A L, Gao M 2010 Acupuncture Research 35 61 (in Chinese) [刘堂义, 杨华元, 蒯乐, 高明 2010 针刺研究 35 61]
[34]	Quiroga R Q, Nadasdy Z, Ben-Shaul Y 2004 Neural Comput. 16 1661
[35]	Truccolo W, Eden U T, Fellows M R, Donoghue J P, Brown E N 2005 Journal of Neurophysiology 93 1074
[36]	Smith A C, Brown E N 2003 Neural Computation 15 965
[37]	Keat J, Reinagel P, Reid R C, Meister M 2001 Neuron 30 803
[38]	Pillow J, Shlens J, Paninski L, Sher A, Litke A, Chichilnisky E, Simoncelli E 2008 Nature 454 995
[39]	Brown E N, Barbieri R, Ventura V, Kass R E, Frank L M 2002 Neural Computation 14 325
[40]	Akaike H 1994 Proceedings of the first US/Japan conference on the frontiers of statistical modeling: an informational approach Dordrecht, Kluwer, January 31, 1994 p33
[41]	Brown E N, Frank L M, Tang D, Quirk M C, Wilson M A 1998 J. Neurosci. 18 7411
[42]	Tanner M A 1996 Tools for Statistical Inference: Methods for the Exploration of Posterior Distributions and Likelihood Functions (New York: Springer-Verlag)
[43]	Kitagawa G, Gersh W 1996 Smoothness priors analysis of time series (New York: Springer)

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Vol. 62, Issue 9 - 2013-05-05

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