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The major reason why cancer kills is its metastatic potentials. Metastasis is an extremely complex three-dimensional (3D) process. Currently, routine in vivo cancer research still experiences bottlenecks in observation and manipulation, while in vitro research mainly stays in petri-dish levels that limit cell environment with two-dimensional confinements. Therefore, it is in urgent needs to construct 3D in vitro models to deepen the studies in cancer invasion and metastasis. However “how to carry out” is a big question that harasses scientists for decades. In this report, we will systematically discuss several popular technologies for 3D microfabrication and their applications in bio and cancer research. Besides, we will demonstrate our efforts to construct an all-in-one 3D micro ecology simulation system (3D MESS) which highly integrates a UV bio-compatible hydrogel printer, a light-sheet imaging system, and a nano pipette operation system. This novel system will create a brand-new method to fabricate, observe and controls the 3D structures and the cells inside. We believe that these advanced technology and ambitions will definitely update the current cancer research methods and bring promising hopes for future deeper understandings and more efficient treatment of cancer.
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Keywords:
- three-dimensional micro/nano fabrication /
- cancer /
- cancer biophysics /
- in vivo microenvironment
[1] Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun M J 2009 Ca-Cancer J. Clin. 59 225
[2] Wolgemuth C W 2011 Physics 4
[3] Tay C Y, Irvine S A, Boey F Y C, Tan L P, Venkatraman S 2011 Small 7 1361
[4] Pranav Soman, Jonathan Kelber A, Jin Woo Lee 2012 Biomaterials 33 7064
[5] Lu Y, Mapili G, Suhali G, Chen S, Roy K, J. A 2006 Biomed. Mater. Res. 77A 396
[6] Wang S, Foo C W P, Warrier A, Poo M M, Heilshorn S C, Zhang X 2009 Biomed. Microdvices. 11 1127
[7] Hoffman-Kim D, Mitchel J A, Bellamkonda R V 2010 Annu. Rev. Biomed. Eng. 12 203
[8] Zhang A P, Qu X, Soman P 2012 Adv. Mater. 24 4266
[9] Germán Comina, Anke Suskaa, Daniel Filippini 2014 Lab. Chip 14 424
[10] Kuo C T, Kuo C T, Chiang C L, Chang C H, Liu H K, Huang G S, Ruby Yun-Ju Huang, Leec H, Huang C S, Wo A M 2014 Biomaterials 35 1562
[11] Tiemo Bckmann, Nicolas Stenger 2012 Advanced Materials 24 2710
[12] Nelson B J, Kaliakatsos I K, Abbott J J, Annu 2010 Rev. Biomed. Eng. 12 55
[13] Klein F, Striebel T, Fischer J, Jiang Z, Franz C M, Freymann G, Wegener M, Bastmeyer M 2010 Adv. Mater. 22 868
[14] Sangwon Kim, Famin Qiu 2013 Adv. Mater. 25 5863
[15] Ying Zhang, Junmei Chen 2012 PNAS 109 24
[16] Connell J L, Ritschdorff E T 2013 PNAS 110 46
[17] Anselme K, Bigerelle M 2011 Int. Mater. Rev. 56 243
[18] Tina Qing Huang, Qu X, Justin Liu, Shaochen Chen 2014 Biomed Microdevices 16 127
[19] Kolin Hribar C, Pranav Soman, John Warner 2014 Lab. Chip 14 268
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[1] Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun M J 2009 Ca-Cancer J. Clin. 59 225
[2] Wolgemuth C W 2011 Physics 4
[3] Tay C Y, Irvine S A, Boey F Y C, Tan L P, Venkatraman S 2011 Small 7 1361
[4] Pranav Soman, Jonathan Kelber A, Jin Woo Lee 2012 Biomaterials 33 7064
[5] Lu Y, Mapili G, Suhali G, Chen S, Roy K, J. A 2006 Biomed. Mater. Res. 77A 396
[6] Wang S, Foo C W P, Warrier A, Poo M M, Heilshorn S C, Zhang X 2009 Biomed. Microdvices. 11 1127
[7] Hoffman-Kim D, Mitchel J A, Bellamkonda R V 2010 Annu. Rev. Biomed. Eng. 12 203
[8] Zhang A P, Qu X, Soman P 2012 Adv. Mater. 24 4266
[9] Germán Comina, Anke Suskaa, Daniel Filippini 2014 Lab. Chip 14 424
[10] Kuo C T, Kuo C T, Chiang C L, Chang C H, Liu H K, Huang G S, Ruby Yun-Ju Huang, Leec H, Huang C S, Wo A M 2014 Biomaterials 35 1562
[11] Tiemo Bckmann, Nicolas Stenger 2012 Advanced Materials 24 2710
[12] Nelson B J, Kaliakatsos I K, Abbott J J, Annu 2010 Rev. Biomed. Eng. 12 55
[13] Klein F, Striebel T, Fischer J, Jiang Z, Franz C M, Freymann G, Wegener M, Bastmeyer M 2010 Adv. Mater. 22 868
[14] Sangwon Kim, Famin Qiu 2013 Adv. Mater. 25 5863
[15] Ying Zhang, Junmei Chen 2012 PNAS 109 24
[16] Connell J L, Ritschdorff E T 2013 PNAS 110 46
[17] Anselme K, Bigerelle M 2011 Int. Mater. Rev. 56 243
[18] Tina Qing Huang, Qu X, Justin Liu, Shaochen Chen 2014 Biomed Microdevices 16 127
[19] Kolin Hribar C, Pranav Soman, John Warner 2014 Lab. Chip 14 268
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