C60 films were irradiatied ar room temperature by medium-energy(120—360 keV) radiation of different ions (H+, He+, N+, Ar+), and the radiation effects were investigated using Raman spectra. The results showed that the radiation of medium-energy ions could cause C60 films polymerized and amorphous. However, occurrence of the phenomena depends on dosage, which is related to the interaction between the radiation ion and C60 molecule. A possible explanation for the experimental results is given and the mechanism of the interaction between the radiation ion and C60 molecule is discussed.