Structure, magnetic and transport properties of polycrystalline Nd0.5 Sr0.4Pb0.1Mn1-xFexO3 Com pounds were experimentally studies. Single-phase samples were obtained in the range x=0.0—0.1 of Fe Content. There are no appreciable structure changes for the introduction of Fe. Mn-site doping favous a reduction of magnetic/resistive transport, at a rate of ～16K for 6% Fe, and an elevated resistivity. Metal-insulator transition disappears when the content of Fe exceeds ～0.08. The enhanced doping effects in Nd0.5Sr0.4Pb0.1Mn1-xFexO3 can be ascribed to the presence of Fe, which influences the concentration of mobile electron eg and restrain the double exchange interaction in the compounds.