The influence of pressure on the magnetotransport properties of CrO2 samples at low temperatures has been studied in this paper. The X-ray diffraction patterns of the samples show that the relative intensity of (110) peak increases with increasing pressure, which implies that pressure has the orientation effect on the CrO2 needle-shaped nanoparticles. At low temperatures, the resistance and magnetoresistance of CrO2 samples decrease with the increase of pressure. The experimental results suggest that at low temperatures, the conductance of the sample shows the typical characteristic of intergranular tunneling. Δ decreases with increasing pressure and magnetic field; and furthermore, the range of change of Δ with the magnetic field is relatied to the compacting pressure. The higher the compacting pressure, the smaller the variation of Δ with the magnetic field. These changes can be attributed to the adjustment of pressure on the intergranular tunnel barrier.