Measurements were carried out under hydrostatic pressure up to 0.5GPa at room temperature, by using an ultrasonic pulse-echo method to measure the transit time of longitudinal and transverse elastic waves (10MHz) in a Nd60Al10Fe20Co10 bulk metallic glass. Based on the experimental data, the sound velocity, density, elastic moduli and Debye temperature were derived as functions of pressure, and the Murnaghan’s equation of state was obtained. Moreover, the compression curve, the elastic constants and the Debye temperature of the bulk metallic glass are calculated on the basis of the similarity between their physical properties in the glass state and those in corresponding crystalline state. These results confirm that the elastic properties of Nd60Al10Fe20Co10 bulk metallic glass are related to its component elements.