Generally, it is more suitable for studies on Ne-like X-ray laser by using fundamental frequency laser as driving beam than by frequency doubling. However, many huge laser facilities built for ICF research are usually designed for doubling and trebling of laser frequency, and they are unfit for use as fundamental frequency laser. We simulated the Ne-like Ge X-ray laser making use of JB19 codes, respectively in the case of doubled and trebled frequency diving. The results indicated that the higher power output of Ne-like Ge X-ray laser is also obtained when driven by doubled frequency laser. However the required output of driving laser beam was 3.3 times that in the case of the fundamental. Any way it presents a direction of studying Ne-like X-ray laser with huge laser facilities in the future. A preliminary experimental study has proved this point.