The interplay between the fabrication parameters during the fabrication of photonic crystal fibers（PCF） are numerically analyzed. Relation between these parameters and the final fiber’s geometry is identified. With the cooperative control of drawing temperature and feed speed, the final hole structure can be effectively controlled by tuning the applied pressure. A single-mode PCF with its d/Λ approaching 0.45, and a PCF with high air-filling fraction, whose d/Λ equals 0.8, are successfully fabricated. For fabrication of PCFs with uneven-sized holes, parameter control alone is sometimes inadequate in achieving the desired geometry. Taking a single-polarization single-mode（SPSM） PCF structure as example, the preform’s geometry is redesigned for optimization by inverse calculation. And the required SPSM PCF can thus be fabricated.