In this paper, a 3-D chemical release dynamics model including neutral gas diffusion, chemical reaction and ambipolar diffusion of plasma, is proposed first. And then the software frame is developed for the study of chemical releases in the ionosphere. The computer simulation on some representative chemical releases including H2O, CO2, H2 and SF6 is carried out finally. The temporal-spatial effects of the local turbulence introduced by these chemical releases are discussed.