We demonstrate a new method for fabrication of rare-doped silica-based glass, which is liquid doped with non-chemical vapor deposition (non-CVD) melting process. The Ytterbium doped silica-based glass with the ratio of 98SiO2-0.5Yb2O3-1.5Al2O3wt% is achieved by using this method. The refractive index (nD) and the density(ρ) of the glass are 1.519 and 2.62g/cm3 respectively. In measurement experiment, it shows that it has strong absorption in the wavelength range from 850nm to 1050nm, and the main absorption peak is at 978nm and the secondary absorption peak is at 919nm. Using the laser with wavelength of 978nm as pumping source, the emission peak is at 1018nm in the fluorescence spectrum with a 71.8nm fluorescence half-line width. Meanwhile, the integrated absorption cross section, stimulated emission cross section, fluorescence time, saturated pump intensity, minimum pump intensity and other parameters are calculated. Test results indicate that the doped silica-based glass has good thermal stability and large power threshold, which is an ideal gain medium for large power photonic crystal fiber lasers.