In this paperan improved dissipative particle dynamics(DPD) method was applied to simulate droplet motion in a grooved microchannel. The improved DPD method adopted a recently proposed combination of short-range repulsive and long-range attractive interaction, which can simulate fluid flows with free surfaces, such as droplet motions. The static contact angle between the droplet and the solid wall was simulated with the new potential function, andstatic contactangle～awf/af curve was obtained by Polynomial fit of the 2nd order. The influences ofwall wettability, flow field force, droplet temperature on the flow pattern of droplet in the grooved microchannel were investigated. The results showed that wall wettability and flow field force have large affectson the flow pattern of the droplet, whiledroplet temperature have little affectson it. This article is helpful to understand the fluid flow behavior with free surfaces on rough surfaces.