In this paper, we use the Huxley potential function to fit the interaction energy data, which have been calculated at the theoretical level of the QCISD(T)/aug-cc-pVTZ. Differential and partial cross-sections of 16Ne, 20Ne, 34Ne atoms and HF molecule collisions are calculated by the accurate close-coupling approximation method when the incident energy is 100meV. We study the changing tendencies of Ne-HF collisional cross-sections with Ne isotopic substitution.