In this paper, the stochastic resonance of two-dimensional Duffing oscillator under the adiabatic assumption is studied. For the large parameter condition, we propose the large parameter stochastic resonance of two-dimensional Duffing oscillator, and discuss the relationship between the scale transformation stochastic resonance and the parameter adjustment stochastic resonance. Then we reveal the mechanism of signal detection by Duffing oscillator stochastic resonance in large parameter condition, and extend its application to weak signal detection.