Quantum phase space theory is widely used to investigate physical, and chemical questions. It gives us a powerful tool to study the relations between the classical and quantum world. In quantum phase space theory, entangled molecular dynamics method is developed based on quantum Liouville equation. It is different from classical Hamilton dynamics, the trajectories are entangled i.e. not independent with each other. The quantum effect in the system can be described using the semiclassical theory, and give a vivid physical picture. The quantum tunneling, photodissociation, and self-correlation are investigated using the entangled trajectory. In this paper, we review the recent development in this field.