A blending crossover differential evolution algorithm is proposed to increase the precision of camera-space manipulation (CSM) system. In this approach, six view parameters and flattening parameter are assembled into a single parameter of blending crossover differential evolution; the positioning precision of camera-space manipulation is set to be a fitness function.The CSM system can obtain the optimal parameter combination by evolutionary iteration.Experimental results of a virtual robot system show the robot positioning precision is improved by blending crossover differential evolution algorithm.