Biomimetic microfluidic systemscan be obtained through multidisciplinary approaches by using bio-inspired structural and functional designsfor the microfluidic devices. This review mainly focuseson the concept of biomimetic microfluidics to improve the properties of microfluidic systemsfor breaking through the bottlenecks of the current microfluidic devices, such as antifoulingsmart, anddynamic response insidethe microchannelsunder different environments. In addition, herewe showthecurrentresearch progress ofbiomimetic microfluidic systems in applicationsrelatedtoantifoulingandsmartdevices, andbiomedicalresearch The review discusses both physical theories and critical technologies in thebiomimetic microfluidics, from biomimetic design to real-worldapplications, so as to offer new ideas for the design and application of smart microfluidics, and the authors hope this review will inspire the active interest of many scientists in the area of the development and application of soft matter, and multi-functional and smart biomimetic devices.