In order to analyze the causes of star sensor performance degradation and attitude measurement accuracy reduction in space radiation environment, the total ionizing dose effects on complementary metal oxide semiconductor (CMOS) star sensor performance are studied. By using an established outfield star sensor test system, the Orion Nebula and the zenith direction of the sky are imaged. Through the experimental processes of star map data acquisition, star point extraction and star map matching, the influence mechanisms of complementary metal oxide semiconductor active pixel sensor (CMOS APS) noises on background gray mean value of star map and number of identified stars are analyzed. A recognition algorithm for finding stars annihilated by radiated noise is proposed. Through theoretical derivation, the quantitative relationships between CMOS APS dark current noise, dark signal non-uniformity noise and photon response non-uniformity noise and star centroid positioning error are established. The γ radiation results show that the image gray-mean of the whole star map increases, the number of identified stars decreases, and the star point centroid positioning accuracy decreases, which seriously affect star map recognition of star sensor. This research provides a theoretical basis for the radiation-resistant reinforcement design of high precision star sensors.