The crystal structure, oxygen content, resistance, Hall effect and superconducting crkical temperature of YBa2Cu1-xCox(Cu1-yZny)2Oz system (0≤x, y≤0.1) have been studied. It is found that with increase of Co and Zn contents, the transformation from superconducting metal with orthorhombic structure to non-superconducting semiconductor with tetragonal structure occurs. At the same time, the Tc and the carrier density nh decrease sharply. The effects with Co and Zn doping simultaneously are not simply additive. With increase of Co and Zn concentrations, there is a strong coorelation between Co doping on Cu(l) and Zn on Cu (2) sites. The experimental results show that the coupling between Cu-O planes and Cu-O chains gives much influence on the electronic transport properties in normal states and superconductivity. The characteristics of the hole carriers and its dependence on Tc in 123 phase compounds are also dicussed.