The Hong-Ou-Mandel (HOM) interferometer using entangled photon source possesses important applications in quantum precision measurement and relevant areas. In this paper, a simultaneous measurement scheme of multiple independent delay parameters based on a cascaded HOM interferometer is proposed. The cascaded HOM interferometer is composed of
n 
concatenated 50∶50 beam splitters and independent delay parameters
\tau _1 
,
\tau _2 
, ···,
\tau _n 
. The numbers
n=1, 2\;\mathrma\mathrmn\mathrmd\;3 
refer to the standard HOM interferometer, the second-cascaded HOM interferometer, and the third-cascaded HOM interferometer, respectively. Through the theoretical study of the cascaded HOM interference effect based on frequency entangled photon pairs, it can be concluded that there is a corresponding relationship between the dip position and the independent delay parameter in the second-order quantum interferogram. In the standard HOM interferometer, there is a dip in the second-order quantum interferogram, which can realize the measurement of delay parameter
\tau _1 
. In the second-cascaded HOM interferometer, there are two symmetrical dips in the second-order quantum interferogram, which can realize the simultaneous measurement of two independent delay parameters
\tau _1 
and
\tau _2 
. By analogy, in the third-cascaded HOM interferometer, there are six symmetrical dips in the second-order quantum interferogram, which can realize the simultaneous measurement of three independent delay parameters
\tau _1 
,
\tau _2 
and
\tau _3 
. Therefore, multiple independent delay parameters can be measured simultaneously based on a cascaded HOM interferometer.
In the experiment, the second-cascaded HOM interferometer based on frequency entangled photon source is built. The second-order quantum interferogram of the second-cascaded HOM interferometer is obtained by the coincidence measurement device. Two independent delay parameters
\tau _1 
and
\tau _2 
are measured simultaneously by recording the positions of two symmetrical dips, which are in good agreement with the theoretical results. At an averaging time of 3000 s, the measurement accuracy of two delay parameters
\tau _1 
and
\tau _2 
can reach 109 and 98 fs, respectively. These results lay a foundation for extending the applications of HOM interferometer in multi-parameter quantum systems.