Thorium-232 (²³²Th) has been recognized as a promising target material for medical radioisotope production, owing to its low natural radioactivity, good chemical stability, and ease of fabrication. Multiple medically important isotopes—including diagnostic nuclides such as 99Mo and therapeutic α-emitters like ²²³Ra and ²²⁵Ra—can be produced simultaneously with considerable yields when bombarded with medium-to high-energy protons via the p+²³²Th reaction. However, experimental cross-section data for such reactions remain insuffcient and fragmented due to limitations in proton beam application at intermediate energies and delayed progress in nuclear mechanism studies, which hinders the optimization of isotope production strategies and validation of theoretical models. In this work, the production cross sections for key medical isotopes from the p+²³²Th reaction were systematically measured. Irradiation experiments were performed on high-purity thorium oxide targets, fabricated via a high-temperature sintering process to overcome brittleness, using 40-80 MeV protons at the Associated Proton-beam Experiment Platform （APEP） of the China Spallation Neutron Source (CSNS). The activation method combined with off-line γ-ray spectroscopy using a calibrated HPGe detector was employed. Proton flux were monitored via the ^natCu(p,x)⁵⁸Co reaction, and activities were corrected for cooling and counting times to obtain endof-bombardment values. The measured excitation functions were compared with existing EXFOR data, TENDL evaluations, and FLUKA simulations where TENDL data were unavailable. For most nuclides, our results agree well with previous experiments but are systematically lower than TENDL predictions, indicating a need for further benchmarking. Notably, this work measures the first cross-section data for ⁸⁸Y and ¹⁵³Sm in the 40-80 MeV range, filling the existing gaps. In addition， we assessed integral yields for a 5 g/cm² thorium target under six days of continuous 1 μA irradiation， which indicate that yields for ⁹⁹Mo, ¹¹¹Ag, and ¹³¹I reach tens of millicuries and provide general guidance for optimizing production and controlling impurities. This work constitutes the first cross-section measurement of proton-induced reactions carried out at the CSNS APEP, and the results enrich the experimental nuclear database and provide valuable reference data for medical isotope production via the p+²³²Th reaction.