基于双带宽高斯滤波器的磁共振弹性图局域频率估算算法研究与实现

汪红志; 蔡筱云; 王鹤; 黄清明; 陈奇特; 俞捷; 王晓琰; 陆伦; 黄勇; 程红岩; 张学龙; 李鲠颖

doi:10.7498/aps.60.090204

摘要

本文对生物体软组织的生物力学模型进行了分析推导和简化,得到了磁共振相位图与生物组织弹性之间的力学关系,根据该关系研究了局域频率估算算法,应用Matlab对算法进行了编程实现,体模弹性图的实现验证了算法有效性,为后续开展临床肝纤维化分级研究奠定基础.

关键词:

In the present study we analyze the biomechanical properties of life-form parenchyma, derive the relationship between MR displacement-phase image and the elasticity of life-form parenchyma, thereby study the local frequency estimation(LFE) algorithm. Finally the algorithm is relized by Matlab, and the inversion results of phantom MRE image demonstrate the effectiveness of the LFE algorithm, which would form a basis for subsequent research on liver fibrosis classification .

Keywords:

MRE /
elastic biomechanical model /
LFE

作者及机构信息

(1)第二军医大学附属东方肝胆医院,上海 200438; (2)法国贡比涅工程技术大学,贡比涅,法国; (3)华东师范大学物理系,上海市磁共振重点实验室,上海 200062; (4)华东师范大学物理系,上海市磁共振重点实验室,上海 200062;上海理工大学医学影像工程研究所,上海 200093;上海医疗器械高等专科学校,上海 200093; (5)上海理工大学医学影像工程研究所,上海 200093; (6)上海理工大学医学影像工程研究所,上海 200093;上海医疗器械高等专科学校,上海 200093; (7)通用电器医疗系统(中国)有限公司,上海 201203

基金项目: 上海市科研创新基金(批准号:10YZ237),上海市教育高地建设项目科研基金(批准号:P0502)和上海市教育发展基金会"晨光计划"项目(批准号:2010CGB02)资助的课题. #通讯联系人. Email: gyli@phy.ecnu.edu.cn

Authors and contacts

(1)Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China; (2)GE Healthcare (China), Shanghai 201203, China; (3)Institute of Medical Imaging Technology, University of Shanghai Science and Technology, Shanghai 200093, China; (4)Institute of Medical Imaging Technology, University of Shanghai Science and Technology, Shanghai 200093, China;Shanghai Medical Instrumentation College, Shanghai 200093, China; (5)Shanghai Key Laboratory of Magnetic Resonance, De

参考文献

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[13]	Xydeas T, Siegmann K, Sinkus R 2005 Invest. Radio. 4 412
[14]	Hoers G, Jenkyn T, Dresner M 2003 Clini. Biomed. 18 537
[15]	Thomas R, Richard L, K N An. 2003 J. Biomech. 36 1917
[16]	Kemper J, Sinkus R, Lorenzen J. 2004 Rofo Fortschr Rontg 176 1094
[17]	Nicolle S, Lounis M, Willinger R 2005 Biorheology 42 209
[18]	Xu L, Gao P Y, Lin Y 2007 Chin. J. Med. Radio. 41 300
[19]	Rouviere O, Meng Y, Dresner A, Rossman J, Burgart L, Fidler J, Ehman R 2006 Radio. 240 440
[20]	Rouviere O, Meng Y, Dresner A, Rossman J,Burgart L,Fidler J,Ehman R 2005 Proceedings of the International Society for Magnetic Resonance in Medicine Miami, USA, May 7—13, 2005 p340
[21]	Klatt D, Asbach P, Rump J, Papazoglou S, Somasundaram R, Modrow J, BrauIn J, Sack I 2006 Invest. Radio. 41 841
[22]	Yin M, Grimm R, Manduca A, Ehman R 2006 Proceedings of the International Society for Magnetic Resonance in Medicine Seattle, USA, May 6—12, 2006 p2560
[23]	Wang H Z, Xu L F, Yu J, Huang Q, Wang X Y, Lu L, Wang H, Huang Y, Cheng H Y, Zhang X L, Li G Y 2010 Acta Phys. Sin. 59 7455(in Chinese)[汪红志、许凌峰、俞捷、黄清明、王晓琰、陆伦、王鹤、黄勇、程红岩、张学龙、李鲠颖 2010 物理学报 59 7455]
[24]	Cao Y, Yang K Q 2003 Acta Phys. Sin. 52 1984(in Chinese)[曹禺、杨孔庆 2003 物理学报 52 1984]
[25]	Houten D, Paulsen K, Miga M, Kennedy F, Weaver J 1999 Magn. Reson. Med. 42 779
[26]	Houten D, Weaver J, Miga M, Kennedy F, Paulsen K 2000 Med. Phys. 27 101
[27]	Bishop J, Samani A, Sciarretta J, Plwes D 2000 Phys. Med. Biol. 45 2081
[28]	Oliphant T, Manduca A, Ehman RL, Greenleaf J 2001 Magn. Reson. Med. 45 299
[29]	Manduca A, Oliphant TE, Dresner M, Mahowald J, Kruse S, Amromin E, Felmlee J, Greenleaf J, Ehman R 2001 Med. Imag. Analy. 5 237
[30]	Knutsson H, Westin F, Granlund G, 1994 Proceedings of the IEEE intl. conf. on image processing. Texas, USA, Nov 13—16 1 36
[31]	Wang H, Li G Y 2005 Acta Phys. Sin. 54 1431(in Chinese) [王鹤、李鲠颖 2005 物理学报 54 1431]

施引文献

[1]	Sinkus R, Tanter M, Xydeas T, Catheline S, Bercoff J, Fink M 2005 Magn. Reson. Imag. 23 159
[2]	Braun J, Buntkowsky G, Bernanding J, Tolxdorff T, Sack I 2001 Magn. Reson. Imag. 19 703
[3]	Oudry J, Chen J, Kavin J 2009 Magn. Reson. Imag. 30 1145
[4]	McKnight A, Kugel J, Rossman P, Manduca A, Hartmann L, Ehman R 2002 AJR 178 1411
[5]	Sinkus R. MR-Elastography 2006 MR Physics for Physicists. 5 1
[6]	Meng Y, Talwalkar J, Glaser J, Manduca A, Grimm C, Rossman J, Fidler L, Ehman L 2007 Clin. Gastroenterol. H 10 1207
[7]	Laurent Huwart, Frank Peeters, Ralph Sinkus 2006 NMR Biomed. 19 173
[8]	Hamer O, Aguirre D, Casola G 2006 Radiographics 26 1637
[9]	Muthupillai R, Lomas D, Rossman P, Greenleaf J,Manduca A, Ehman R 1995 Science 269 1854
[10]	Muthupillai R, Rossman P, Lomas D, Greenleaf J,Riederer S, Ehman R 1996 Magn. Reson. Med. 36 266
[11]	Sinkus R, Tanter M, Xydeas T 2005 Magn. Reson. Imag. 23 159
[12]	Sinkus R, Tanter M, Catheline S 2005 Magn. Reson. Med. 53 372
[13]	Xydeas T, Siegmann K, Sinkus R 2005 Invest. Radio. 4 412
[14]	Hoers G, Jenkyn T, Dresner M 2003 Clini. Biomed. 18 537
[15]	Thomas R, Richard L, K N An. 2003 J. Biomech. 36 1917
[16]	Kemper J, Sinkus R, Lorenzen J. 2004 Rofo Fortschr Rontg 176 1094
[17]	Nicolle S, Lounis M, Willinger R 2005 Biorheology 42 209
[18]	Xu L, Gao P Y, Lin Y 2007 Chin. J. Med. Radio. 41 300
[19]	Rouviere O, Meng Y, Dresner A, Rossman J, Burgart L, Fidler J, Ehman R 2006 Radio. 240 440
[20]	Rouviere O, Meng Y, Dresner A, Rossman J,Burgart L,Fidler J,Ehman R 2005 Proceedings of the International Society for Magnetic Resonance in Medicine Miami, USA, May 7—13, 2005 p340
[21]	Klatt D, Asbach P, Rump J, Papazoglou S, Somasundaram R, Modrow J, BrauIn J, Sack I 2006 Invest. Radio. 41 841
[22]	Yin M, Grimm R, Manduca A, Ehman R 2006 Proceedings of the International Society for Magnetic Resonance in Medicine Seattle, USA, May 6—12, 2006 p2560
[23]	Wang H Z, Xu L F, Yu J, Huang Q, Wang X Y, Lu L, Wang H, Huang Y, Cheng H Y, Zhang X L, Li G Y 2010 Acta Phys. Sin. 59 7455(in Chinese)[汪红志、许凌峰、俞捷、黄清明、王晓琰、陆伦、王鹤、黄勇、程红岩、张学龙、李鲠颖 2010 物理学报 59 7455]
[24]	Cao Y, Yang K Q 2003 Acta Phys. Sin. 52 1984(in Chinese)[曹禺、杨孔庆 2003 物理学报 52 1984]
[25]	Houten D, Paulsen K, Miga M, Kennedy F, Weaver J 1999 Magn. Reson. Med. 42 779
[26]	Houten D, Weaver J, Miga M, Kennedy F, Paulsen K 2000 Med. Phys. 27 101
[27]	Bishop J, Samani A, Sciarretta J, Plwes D 2000 Phys. Med. Biol. 45 2081
[28]	Oliphant T, Manduca A, Ehman RL, Greenleaf J 2001 Magn. Reson. Med. 45 299
[29]	Manduca A, Oliphant TE, Dresner M, Mahowald J, Kruse S, Amromin E, Felmlee J, Greenleaf J, Ehman R 2001 Med. Imag. Analy. 5 237
[30]	Knutsson H, Westin F, Granlund G, 1994 Proceedings of the IEEE intl. conf. on image processing. Texas, USA, Nov 13—16 1 36
[31]	Wang H, Li G Y 2005 Acta Phys. Sin. 54 1431(in Chinese) [王鹤、李鲠颖 2005 物理学报 54 1431]

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