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基于线性成像系统的光学超分辨显微术回顾

胡睿璇 潘冰洋 杨玉龙 张伟华

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基于线性成像系统的光学超分辨显微术回顾

胡睿璇, 潘冰洋, 杨玉龙, 张伟华

Brief retrospect of super-resolution optical microscopy techniques

Hu Rui-Xuan, Pan Bing-Yang, Yang Yu-Long, Zhang Wei-Hua
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  • 随着纳米科学技术的发展,如何打破光学衍射极限,将光学显微术的分辨本领推进到纳米尺度,已经成为光学领域的一个核心议题.在此背景下,过去的三十年间,发展了多种超分辨光学显微技术,并在生物、材料、化学领域取得了一系列令人瞩目的应用.本文以衍射理论为线索,回顾各类基于线性成像系统的超分辨光学显微技术;对以固浸物镜、结构光照明、扫描近场光学显微术、完美透镜以及超振荡透镜为代表的超分辨光学显微技术进行综述,讨论各种技术的原理,对其特点、应用与局限加以总结,并对该领域的未来发展予以展望.
    In the last few decades, nanoscience and nanotechnology have been growing with breath taking speed, and how to break through the diffraction limit and tame the light on a nanoscale have become the major challenges in optics. In this field, several super-resolution optical nanoscopy techniques have been developed, leading to a series of breakthroughs in physics, chemistry, and life sciences. In the work, we give a retrospect of the newly developed techniques in diffraction theory of linear optical systems, including the solid immersion lens, structured light illumination microscopy, scanning near-field optical microscopy, metamaterial-based wide field near-field imaging technique and super-oscillatory lens. Brief discussion on their principles, advantages and applications is also provided.
      通信作者: 张伟华, zwh@nju.edu.cn
    • 基金项目: 国家重点研发计划(批准号:2016YFA0201104)、国家重点基础研究发展计划(批准号:2015CB659400)和国家自然科学基金(批准号:11374152,11574142,11621091)资助的课题.
      Corresponding author: Zhang Wei-Hua, zwh@nju.edu.cn
    • Funds: Project supported by the National Key Technologies RD Program of China (Grant No. 2016YFA0201104), the National Basic Research Program of China (Grant No. 2015CB659400), and the National Natural Science Foundation of China (Grant Nos. 11374152, 11574142, 11621091).
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    Synge E H 1928 Phil. Mag. 6 356

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    [6]

    Betzig E, Trautman J K, Harris T D, et al. 1991 Science 251 1468

    [7]

    Betzig E, Trautman J K 1992 Science 257 189

    [8]

    Ash E A, Nicholls G 1972 Nature 237 510

    [9]

    Lewis A, Isaacson M, Harootunian A, Muray A 1984 Ultramicroscopy 13 227

    [10]

    Pohl D W, Denk W, Lanz M 1984 Appl. Phys. Lett. 44 651

    [11]

    Binnig G R H 1981 IBM J. Res. Dev. 30 355

    [12]

    Thomas A K, Hell S W 1999 Opt. Lett. 24 954

    [13]

    Rust M J, Bates M, Zhuang X 2006 Nat. Methods 3 793

    [14]

    Fang N, Lee H, Sun C, Zhang X 2005 Science 308 534

    [15]

    Taubner T, Korobkin D, Urzhumov Y, et al. 2006 Science 313 1595

    [16]

    Smolyaninov II, Hung Y J, Davis C C 2007 Science 315 1699

    [17]

    Gustafsson M G L 2000 J. Microsc. 198 82

    [18]

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    [19]

    Betzig E, et al. 2006 Science 313 1642

    [20]

    Rogers E T F, et al. 2012 Nat. Materials 11 432

    [21]

    Hell S W 2007 Science 316 1153

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    Jones S A, Shim S H, He J, Zhuang X W 2011 Nat. Methods 8 499

    [23]

    Pohl D W, Kawata S 2001 Near-Field Optics and Surface Plasmon Polaritons (Germany: Springer-Verlag)

    [24]

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    [26]

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    [27]

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    [31]

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    [32]

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    [33]

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    [34]

    Wang Z, et al. 2011 Nat. Commun. 2 218

    [35]

    Lukosz W, Marchand M 1963 J. Mod. Opt. 10 241

    [36]

    Heintzmann R, Cremer C 1999 Proc. SPIE 3568 185

    [37]

    Frohn J T, Knapp H F, Stemmer A 2000 Proc. Nat. Acad. Sci. USA 97 7232

    [38]

    Gustafsson M G L, Agard D A, Sedat J W 2000 Proc. SPIE 3919 141

    [39]

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    [50]

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    [51]

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    [52]

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出版历程
  • 收稿日期:  2017-03-29
  • 修回日期:  2017-06-21
  • 刊出日期:  2017-07-05

基于线性成像系统的光学超分辨显微术回顾

  • 1. 南京大学现代工程与应用科学学院, 南京大学固体微结构物理国家重点实验室, 南京大学人工微结构科学与技术协同创新中心, 南京 210093
  • 通信作者: 张伟华, zwh@nju.edu.cn
    基金项目: 国家重点研发计划(批准号:2016YFA0201104)、国家重点基础研究发展计划(批准号:2015CB659400)和国家自然科学基金(批准号:11374152,11574142,11621091)资助的课题.

摘要: 随着纳米科学技术的发展,如何打破光学衍射极限,将光学显微术的分辨本领推进到纳米尺度,已经成为光学领域的一个核心议题.在此背景下,过去的三十年间,发展了多种超分辨光学显微技术,并在生物、材料、化学领域取得了一系列令人瞩目的应用.本文以衍射理论为线索,回顾各类基于线性成像系统的超分辨光学显微技术;对以固浸物镜、结构光照明、扫描近场光学显微术、完美透镜以及超振荡透镜为代表的超分辨光学显微技术进行综述,讨论各种技术的原理,对其特点、应用与局限加以总结,并对该领域的未来发展予以展望.

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