In this paper, we employ molecular static approach with quantum corrected Sutten-Chen many-body potential to study the mechanical behavior of nickel nanofilm during uniaxial loading, and investigate its microstructure by common neighbor analysis methods. The simulated results show that the existence of void significantly weakens the Young’s modulus and yield stress of nanofilm; with the increased strain, the shape of void changes from circular into elliptical, and the void is eventually entirely closed. The plastic deformation of nanofilm is characterized by 111 glide associated with Shockley partial dislocations, resulting in the formation of stacking faults.