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Due to unnoticeable changes in complex refractive index of tissue under varied pathological and physiological states, the traditional optical coherence tomography (OCT) is deficient in molecular characterization. In this paper, the stimulated-emission based optical coherence tomography is proposed, which provides both molecular contrast and scattering contrast OCT imaging simultaneously. Based on the established ultra-high resolution spectral domain OCT system, a pump-probe spectral domain OCT system with a single wide-bandwidth light source is developed through an added modulated pump beam via spectrum splitting. In addition, the theory about the stimulated-emission signal and the image formulation under the modulated pump beam is presented. The coherent detection of the transient stimulated emission is realized by the developed pump-probe spectral domain OCT system. With the stimulated-emission OCT signal and the traditional OCT signal obtained at the same time, molecular contrast OCT images of the samples consisting of nitride powder are reconstructed successfully.
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Keywords:
- optical coherence tomography /
- stimulated emission /
- pump-probe detection /
- molecular specificity
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[1] Huang D, Swanson E A, Lin C P, Schuman J S, Stinson W G, Chang W, Hee M R, Flotte T, Gregory K, Puliafito C A, Fujimoto J G 1991 Science 254 1178
[2] Izatt J A, Hee M R, Owen G M, Swanson E A, Fujimoto J G 1994 Opt. Lett. 19 590
[3] Drexler W, Fujimoto J G 2008 Optical Coherence Tomography:Technology and Applications (Berlin:Springer) pp1-72
[4] Drexler W, Morgner U, Ghanta R K, Kärtner F X, Schuman J S, Fujimoto J G 2001 Nat. Med. 7 502
[5] Welzel J, Lankenau E, Birngruber R, Engelhardt R 1997 J. Am. Acad. Dermatol. 37 958
[6] Welzel J 2001 Skin Res. Technol. 7 1
[7] Fujimoto J G 2003 Nat. Biotechnol. 21 1361
[8] Adler D C, Chen Y, Huber R, Schmitt J, Connolly J, Fujimoto J G 2007 Nat. Photon. 1 709
[9] Liu L, Gardecki J A, Nadkarni S K, Toussaint J D, Yagi Y, Bouma B E, Tearney G J 2011 Nat. Med. 17 1010
[10] Yan X G, Shen Y, Pan C, Li P, Ding Z H 2016 Acta Phys. Sin. 65 024201 (in Chinese)[严雪过, 沈毅, 潘聪, 李鹏, 丁志华 2016 物理学报 65 024201]
[11] Tang T, Zhao C, Chen Z Y, Li P, Ding Z H 2015 Acta Phys. Sin. 64 174201 (in Chinese)[唐弢, 赵晨, 陈志彦, 李鹏, 丁志华 2015 物理学报 64 174201]
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[13] Yan Y Z, Ding Z H, Wang L, Shen Y 2013 Acta Phys. Sin. 62 164204 (in Chinese)[颜扬治, 丁志华, 王玲, 沈毅 2013 物理学报 62 164204]
[14] Huang L M, Ding Z H, Hong W, Wang C 2012 Acta Phys. Sin. 61 023401 (in Chinese)[黄良敏, 丁志华, 洪威王川 2012 物理学报 61 023401]
[15] Xue P, Fujimoto J G 2008 Chin. Sci. Bull. 53 1963
[16] Liang Y M, Zhou D C, Meng F Y, Wang M W 2007 Acta Phys. Sin. 56 3246 (in Chinese)[梁艳梅, 周大川, 孟凡勇王明伟 2007 物理学报 56 3246]
[17] Robles F E, Wilson C, Grant G, Wax A 2011 Nat. Photon. 5 744
[18] Rao K D, Choma M A, Yazdanfar S, Rollins A M, Izatt J A 2003 Opt. Lett. 28 340
[19] Applegate B E, Izatt J A 2006 Opt. Express 14 9142
[20] Desmond J, Shelton R L, Applegate B E 2010 Opt. Express 18 12399
[21] Kim W, Applegate B E 2015 Opt. Lett. 40 1426
[22] Yoo H, Kim J W, Shishkov M, Namati E, Morse T, Shubochkin R, McCarthy J R, Ntziachristos V, Bouma B E, Jaffer F A, Tearney G J 2011 Nat. Med. 17 1680
[23] Min W, Lu S, Chong S, Roy R, Holtom G R, Xie X S 2009 Nature 461 1105
[24] Wei L, Min W 2012 Anal. Bioanal. Chem. 403 2197
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