Near-Zero-Field NMR and hyperpolarization technology

LI Zeming; LV Yunxi; QI Haogang; QU Qianyue; TAN Zheng; WANG Li; JIANG Weiping; HU Yinan; ZHOU Xin

doi:10.7498/aps.74.20250771

Abstract
Near-zero-field nuclear magnetic resonance (NMR) has emerged as a rapidly evolving approach for spectroscopy and imaging, offering promising opportunities in portable diagnostics and fast chemical analysis. A key technology is the atomic magnetometer, whose continuous improvement has stimulated interest in potential clinical applications. Near-zero-field NMR has long been limited by weak signal strength, but recent developments in hyperpolarization methods offer effective solutions. Dissolution dynamic nuclear polarization (dDNP), parahydrogen-based polarization schemes (PHIP/SABRE), chemically induced dynamic nuclear polarization (CIDNP), and spin-exchange optical pumping (SEOP) have all demonstrated initial feasibility in this context.
By combining such hyperpolarization strategies with near-zero-field detection, strong signals can be obtained without the need for conventional high-field magnets. This capability opens new pathways for applying near-zero-field NMR to both chemical sensing and biomedical imaging, enabling compact tools for rapid analysis and diagnostic applications. Here, we review the recent progress at the intersection of near-zero-field NMR and hyperpolarization techniques.

Keywords:
Near-zero-field NMR /

hyperpolarization /

magnetometer /

MRI
Cited By

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