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Investigation on the application of phase-attenuation duality to X-ray mixed contrast quantitative micro-tomography

Liu Hui-Qiang Ren Yu-Qi Zhou Guang-Zhao He You Xue Yan-Ling Xiao Ti-Qiao

Investigation on the application of phase-attenuation duality to X-ray mixed contrast quantitative micro-tomography

Liu Hui-Qiang, Ren Yu-Qi, Zhou Guang-Zhao, He You, Xue Yan-Ling, Xiao Ti-Qiao
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  • Weak absorption is the main condition of conventional phase retrieval of in-line X-ray phase-contrast CT. The absorption of most samples, however, cannot be neglected in practice, it is needed to find new algorithms of attaining quantitative information. The phase retrieval algorithm of phase-attenuation duality (PAD) is used to realize the quantitative imaging of different density parts in a mixed contrast sample, and the digital simulation and experimental investigation are carried out in order to prove its feasibility in this paper. The simulated results show that the reconstructive errors of three materials are less than 1%, and the values decrease with the increase of refractive index. The experiment was carried out in the X-ray imaging and biological application beam-line of Shanghai Synchrotron Facility, and the results show that the PAD method can attain the sample quantitative information and the reconstructive accuracy is relatively low compared with that of simulation. Through the analysis of experimental data, ring artifact is mostly the primary cause. One single projection data set is used only in simulation and experiment. So the PAD approach can be applied to the quantitative information research of mixed contrast objects. In addition, because of the relatively low radiation dose, it should be suited to investigate the quantitative phase-contrast CT of biomedical sample with soft tissue and bone together.
      Corresponding author: , tqxiao@sinap.ac.cn
    • Funds: Project supported by the National Basic Research Program of China (Grant No. 2010CB834301), the External Cooperation Program of Chinese Academy of sciences (Grant No. GJHZ09058), the National Natural Science Foundation of China (Grant Nos. 10805071, 10705020), and the Key Basic Research Program of Shanghai, China (Grant No. 08Jc1411900).
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    Chen R C 2010 Ph. D. Thesis (Shanghai: Shanghai Institute of Applied Physics, Chinese Academy of Sciences) (in Chinese) [陈荣昌 2010 博士学位论文 (上海:中国科学院上海应用物理研究所)]

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    Xue Y L, Xiao T Q,Wu L H, Chen C, Guo R Y, Du G H, Xie H L, Deng B, Ren Y Q, Xu H J 2010 Acta Phys. Sin. 59 5496 [薛艳玲, 肖体乔, 吴立宏, 陈灿, 郭荣怡, 杜国浩, 谢红兰, 邓彪, 任玉琦, 徐洪杰 2010 物理学报 textbf 59 5496]

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    Chen R C, Longo R, Rigon L, Zanconati F, Pellegrin A De, Arfelli F, Dreossi D, Menk R H, Vallazza E, Xiao T Q, Castelli E 2010 Phys. Med. Biol. 55 4993

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    Zhou G Z, Tong Y J, Chen C, Ren Y Q,Wang Y D, Xiao T Q 2011 Acta Phys. Sin. 60 028071 [周光照, 佟亚军, 陈灿, 任玉琦, 王玉丹, 肖体乔 2011 物理学报 textbf 60 028071]

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    Chen R C, Xie H L, Rigon L, Longo R, Castelli E, Xiao T Q 2011 Opt. Lett. 36 1719

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    Yuqi Ren, Can Chen, Rongchang Chen, Guangzhao Zhou, Yudan Wang, Tiqiao Xiao 2011 Opt. Express. 19 4170

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    Su X Y, Li J T 1999 Information Optics (1st Edition) (Beijing: Science Press) p3446 (in Chinese) [苏显渝, 李继陶 1999 信息光学 (第一版) (北京: 科学出版) 第3446页]

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    Hsieh J 2006 Computed Tomography: Principle, Design, Artifacts and Recent Advances (1st Edition) (Beijing: Science Press) p27 50 (in Chinese) [ 谢强 2006 计算机断层成像技术: 原理、设计、伪像和进展 (第一版) (北京: 科学出版社) 第2750页]

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    Wu X Z, Liu H, Yan A M 2008 EJR 68S S8

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    Wu X Z, Liu H, Yan A M 2005 Opt. Lett. 30 379

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    Guigay J P, Langer M, Boistel R, Cloetens P 2007 Opt. Lett. 32 1617

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    Wu X Z, Yan A M 2009 Opt. Express. 17 11187

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    Groso A, Stampanoni M, Abela R, Schneider P, Linga S, Muller R 2006 Appl. Phys. Lett. 88 214014

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    Langer M, Cloetens P, Guigay J P, Peyrin F 2008 Am. Assoc. Phys. Med. 35 4556

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    Zabler S, Cloetens P, Guigay J P, Baruchel J 2005 Rev. Sci. Instrum. 76 073705

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    Langer M, Cloetens P, Peyrin F 2009 J. Opt. Soc. Am. A 26 1876

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    Cloetens P, Mache R, Schlenker M, Mache S L 2006 PNAS 103 14626

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    Langer M, Peyrin F 2010 IEEE 19 2428

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    Groso A, Abela R, Stampanoni M 2006 Opt. Express 14 8103

  • [1]

    Chen R C, Xie H L, Du G H, Deng B, Zhu P P, Tong Y J, Wang Y D, Xiao T Q 2010 Acta Opt. Sin. 30 1106 [陈荣昌, 谢红兰, 杜国浩, 邓彪, 朱佩平, 佟亚军, 王玉丹, 肖体乔 2010 光学学报 textbf 30 1106]

    [2]

    Chen R C 2010 Ph. D. Thesis (Shanghai: Shanghai Institute of Applied Physics, Chinese Academy of Sciences) (in Chinese) [陈荣昌 2010 博士学位论文 (上海:中国科学院上海应用物理研究所)]

    [3]
    [4]

    Xue Y L, Xiao T Q,Wu L H, Chen C, Guo R Y, Du G H, Xie H L, Deng B, Ren Y Q, Xu H J 2010 Acta Phys. Sin. 59 5496 [薛艳玲, 肖体乔, 吴立宏, 陈灿, 郭荣怡, 杜国浩, 谢红兰, 邓彪, 任玉琦, 徐洪杰 2010 物理学报 textbf 59 5496]

    [5]
    [6]
    [7]

    Chen R C, Longo R, Rigon L, Zanconati F, Pellegrin A De, Arfelli F, Dreossi D, Menk R H, Vallazza E, Xiao T Q, Castelli E 2010 Phys. Med. Biol. 55 4993

    [8]

    Zhou G Z, Tong Y J, Chen C, Ren Y Q,Wang Y D, Xiao T Q 2011 Acta Phys. Sin. 60 028071 [周光照, 佟亚军, 陈灿, 任玉琦, 王玉丹, 肖体乔 2011 物理学报 textbf 60 028071]

    [9]
    [10]
    [11]

    Chen R C, Xie H L, Rigon L, Longo R, Castelli E, Xiao T Q 2011 Opt. Lett. 36 1719

    [12]
    [13]

    Yuqi Ren, Can Chen, Rongchang Chen, Guangzhao Zhou, Yudan Wang, Tiqiao Xiao 2011 Opt. Express. 19 4170

    [14]
    [15]

    Su X Y, Li J T 1999 Information Optics (1st Edition) (Beijing: Science Press) p3446 (in Chinese) [苏显渝, 李继陶 1999 信息光学 (第一版) (北京: 科学出版) 第3446页]

    [16]

    Hsieh J 2006 Computed Tomography: Principle, Design, Artifacts and Recent Advances (1st Edition) (Beijing: Science Press) p27 50 (in Chinese) [ 谢强 2006 计算机断层成像技术: 原理、设计、伪像和进展 (第一版) (北京: 科学出版社) 第2750页]

    [17]
    [18]
    [19]

    Wu X Z, Liu H, Yan A M 2008 EJR 68S S8

    [20]

    Wu X Z, Liu H, Yan A M 2005 Opt. Lett. 30 379

    [21]
    [22]
    [23]

    Guigay J P, Langer M, Boistel R, Cloetens P 2007 Opt. Lett. 32 1617

    [24]
    [25]

    Wu X Z, Yan A M 2009 Opt. Express. 17 11187

    [26]

    Groso A, Stampanoni M, Abela R, Schneider P, Linga S, Muller R 2006 Appl. Phys. Lett. 88 214014

    [27]
    [28]

    Langer M, Cloetens P, Guigay J P, Peyrin F 2008 Am. Assoc. Phys. Med. 35 4556

    [29]
    [30]
    [31]

    Zabler S, Cloetens P, Guigay J P, Baruchel J 2005 Rev. Sci. Instrum. 76 073705

    [32]
    [33]

    Langer M, Cloetens P, Peyrin F 2009 J. Opt. Soc. Am. A 26 1876

    [34]

    Cloetens P, Mache R, Schlenker M, Mache S L 2006 PNAS 103 14626

    [35]
    [36]

    Langer M, Peyrin F 2010 IEEE 19 2428

    [37]
    [38]
    [39]

    Groso A, Abela R, Stampanoni M 2006 Opt. Express 14 8103

  • [1] Wang Wen-Hui,  Zhang Nao. Energy loss of surface plasmon polaritons on Ag nanowire waveguide. Acta Physica Sinica, 2018, 67(24): 247302. doi: 10.7498/aps.67.20182085
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  • Received Date:  20 June 2011
  • Accepted Date:  05 April 2012
  • Published Online:  05 April 2012

Investigation on the application of phase-attenuation duality to X-ray mixed contrast quantitative micro-tomography

    Corresponding author: tqxiao@sinap.ac.cn
  • 1. Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China;
  • 2. Graduate University of Chinese Academy of Sciences, Beijing 100049, China
Fund Project:  Project supported by the National Basic Research Program of China (Grant No. 2010CB834301), the External Cooperation Program of Chinese Academy of sciences (Grant No. GJHZ09058), the National Natural Science Foundation of China (Grant Nos. 10805071, 10705020), and the Key Basic Research Program of Shanghai, China (Grant No. 08Jc1411900).

Abstract: Weak absorption is the main condition of conventional phase retrieval of in-line X-ray phase-contrast CT. The absorption of most samples, however, cannot be neglected in practice, it is needed to find new algorithms of attaining quantitative information. The phase retrieval algorithm of phase-attenuation duality (PAD) is used to realize the quantitative imaging of different density parts in a mixed contrast sample, and the digital simulation and experimental investigation are carried out in order to prove its feasibility in this paper. The simulated results show that the reconstructive errors of three materials are less than 1%, and the values decrease with the increase of refractive index. The experiment was carried out in the X-ray imaging and biological application beam-line of Shanghai Synchrotron Facility, and the results show that the PAD method can attain the sample quantitative information and the reconstructive accuracy is relatively low compared with that of simulation. Through the analysis of experimental data, ring artifact is mostly the primary cause. One single projection data set is used only in simulation and experiment. So the PAD approach can be applied to the quantitative information research of mixed contrast objects. In addition, because of the relatively low radiation dose, it should be suited to investigate the quantitative phase-contrast CT of biomedical sample with soft tissue and bone together.

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