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The extreme pH-induced lateral reorganization of supported lipid bilayer membranes are studied by fluorescence microscopy. The results show that the fluid dioleoyl-phosphatidylcholine bilayers in extreme acidic or basic solution presents a similar phenomenon to endocytosis and exocytosis, such as rupture, detachment, budding, formation of microtubules etc. In the view of the interaction of polar molecules with H+/H3O+ or OH ions, we conclude that the zwitterionic phospholipid headgroup as core adsorbs the H+/H3O+ or OH ions in electrolyte solution. The asymmetric charge adsorption quantity of the lipid headgroups leads to the effective area discrepancy between the outer and inner leaflets of lipid bilayers. The asymmetric membrane curvatures induce a variety of structures and dynamic responses. The present study helps explain lipid membranes reorganization under extreme pH conditions and provides some guidelines for deformation process of lipid membranes.
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Keywords:
- supported lipid bilayers /
- pH value /
- membrane curvature /
- lateral reorganization
[1] Suresh S, Edwardson J M 2010 Biochem. Bioph. Res. Co. 399 571
[2] Li L, Liang X Y, Lin M Y, Qiu F, Yang Y L 2005 JACS 127 17996
[3] Li R T, Xie L, Zhu Z S, Liu Q, Hu Y, Jiang X Q, Yu L X, Qian X P, Guo W H, Ding Y T, Liu B R 2011 PLoS One 6 24172
[4] Li D X, He Q, Cui Y, Li J B 2007 Chem. Mater. 19 412
[5] Yang K, Ma Y Q 2012 Soft Matter 8 606
[6] Zhou X H, Zhang S G, Yang J Q, Qu X M, Liu Y S, Wang S G 2007 Acta Phys. Sin. 56 6137 (in Chinese) [周晓华, 张劭光, 杨继庆, 屈学民, 刘渊声, 王斯刚 2007 物理学报 56 6137]
[7] Xie Y Z, Liu J X, Ouyang Z C 2002 Elastic Theory of Surfaces of Biomembrane-Vesicle (Shanghai: Shanghai Scientific and Technical Publishers) p87 (in Chinese) [谢毓章, 刘寄星, 欧阳钟灿 2002 生物膜泡曲面弹性理论 (上海: 上海科学技术出版社) 第87 页]
[8] Xia B K, Li J F, Li W H, Zhang H D, Qiu F 2013 Acta Phys. Sin. 62 248701 (in Chinese) [夏彬凯, 李剑锋, 李卫华, 张红东, 邱枫 2013 物理学报 62 248701]
[9] Bandekar A, Sofou S 2012 Langmuir 28 4113
[10] Goertz M P, Goyal N, Montano G A, Bunker B C 2011 Langmuir 27 5481
[11] Liu X H, Huang W M, Wang E K 2005 J. Electroanal. Chem. 577 349
[12] Jiang Z Y, Zhang G L, Ma J, Zhu T 2013 Acta Phys. Sin. 62 018701 (in Chinese) [蒋中英, 张国梁, 马晶, 朱涛 2013 物理学报 62 018701]
[13] Yamazaki V, Sirenko O, Schafer R J, Groves J T 2005 JACS 127 2826
[14] Zhang J A A, Pawelchak J 2000 Eur. J. Pharm. Biopharm. 50 357
[15] Wang B, Zhang L F, Bae S C, Granick S 2008 PNAS 105 18171
[16] Garcia-Manyes S, Oncins G, Sanz F 2006 Electrochim. Acta 51 5029
[17] Wang C Y, Tao Y 1993 Glass Surface and Surface Treatment (Beijing: China Building Materials Press) p123 (in Chinese) [王承遇, 陶瑛 1993 玻璃表面和表面处理 (北京: 中国建材工业出版社) 第123页]
[18] Liang X Y 2007 Ph. D. Dissertation (Shanghai: Fudan University) (in Chinese) [梁新宇2007 博士学位论文 (上海: 复旦大学)]
[19] Vacha R, Siu S W I, Petrov M, Bockmann R A, Barucha-Kraszewska J, Jurkiewicz P, Hof M, Berkowitz, M L, Jungwirth P 2009 J. Phys. Chem. A 113 7235
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[1] Suresh S, Edwardson J M 2010 Biochem. Bioph. Res. Co. 399 571
[2] Li L, Liang X Y, Lin M Y, Qiu F, Yang Y L 2005 JACS 127 17996
[3] Li R T, Xie L, Zhu Z S, Liu Q, Hu Y, Jiang X Q, Yu L X, Qian X P, Guo W H, Ding Y T, Liu B R 2011 PLoS One 6 24172
[4] Li D X, He Q, Cui Y, Li J B 2007 Chem. Mater. 19 412
[5] Yang K, Ma Y Q 2012 Soft Matter 8 606
[6] Zhou X H, Zhang S G, Yang J Q, Qu X M, Liu Y S, Wang S G 2007 Acta Phys. Sin. 56 6137 (in Chinese) [周晓华, 张劭光, 杨继庆, 屈学民, 刘渊声, 王斯刚 2007 物理学报 56 6137]
[7] Xie Y Z, Liu J X, Ouyang Z C 2002 Elastic Theory of Surfaces of Biomembrane-Vesicle (Shanghai: Shanghai Scientific and Technical Publishers) p87 (in Chinese) [谢毓章, 刘寄星, 欧阳钟灿 2002 生物膜泡曲面弹性理论 (上海: 上海科学技术出版社) 第87 页]
[8] Xia B K, Li J F, Li W H, Zhang H D, Qiu F 2013 Acta Phys. Sin. 62 248701 (in Chinese) [夏彬凯, 李剑锋, 李卫华, 张红东, 邱枫 2013 物理学报 62 248701]
[9] Bandekar A, Sofou S 2012 Langmuir 28 4113
[10] Goertz M P, Goyal N, Montano G A, Bunker B C 2011 Langmuir 27 5481
[11] Liu X H, Huang W M, Wang E K 2005 J. Electroanal. Chem. 577 349
[12] Jiang Z Y, Zhang G L, Ma J, Zhu T 2013 Acta Phys. Sin. 62 018701 (in Chinese) [蒋中英, 张国梁, 马晶, 朱涛 2013 物理学报 62 018701]
[13] Yamazaki V, Sirenko O, Schafer R J, Groves J T 2005 JACS 127 2826
[14] Zhang J A A, Pawelchak J 2000 Eur. J. Pharm. Biopharm. 50 357
[15] Wang B, Zhang L F, Bae S C, Granick S 2008 PNAS 105 18171
[16] Garcia-Manyes S, Oncins G, Sanz F 2006 Electrochim. Acta 51 5029
[17] Wang C Y, Tao Y 1993 Glass Surface and Surface Treatment (Beijing: China Building Materials Press) p123 (in Chinese) [王承遇, 陶瑛 1993 玻璃表面和表面处理 (北京: 中国建材工业出版社) 第123页]
[18] Liang X Y 2007 Ph. D. Dissertation (Shanghai: Fudan University) (in Chinese) [梁新宇2007 博士学位论文 (上海: 复旦大学)]
[19] Vacha R, Siu S W I, Petrov M, Bockmann R A, Barucha-Kraszewska J, Jurkiewicz P, Hof M, Berkowitz, M L, Jungwirth P 2009 J. Phys. Chem. A 113 7235
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