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Nonspecific adsorption of charged mesoporous nanoparticles on supported thiol/lipid hybrid bilayers

Lu Nai-Yan Yuan Bing Yang Kai

Nonspecific adsorption of charged mesoporous nanoparticles on supported thiol/lipid hybrid bilayers

Lu Nai-Yan, Yuan Bing, Yang Kai
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  • Mesoporous silica nanoparticles (MSN) with cationic and anionic surface charges were synthesized, Their adsorption behaviors to the supported lipid membranes at different pH values were also studied using QCM-D. We found that NH2-MSN could be adsorbed onto the membrane at pH values from 4 to 8, while the adsorption of COOH-MSN onto the membrane could not occur due to its charge being always the same as that of the membrane at any pH values. These results might provide the information for understanding and predicting the interactions between nanoparticles and cell membranes, and could be effectively used in drug delivery systems and disease treatment.
    • Funds: Project supported by the National Natural Science Foundation of China (Grant Nos. 11104192, 21106114), the Key Project of Chinese Ministry of Education, China (Grant No. 210208), and the Applied Basic Research Program of Yunnan Province, China (Grant No. 2010CD091).
    [1]

    Yousaf M Z, Yu J, Hou Y L, Gao S 2013 Chin. Phys. B 22 058702

    [2]

    Liu J W, Jiang X M, Ashley C, Brinker C J 2009 J. Am. Chem. Soc. 131 7567

    [3]

    Giri S, Trewyn B G, Stellmaker M P, Lin V S Y 2005 Angew. Chem. Int. Ed. 44 5038

    [4]

    Hong C Y, Li X, Pan C Y 2008 J. Phys. Chem. C 112 15320

    [5]

    Liu R, Zhang Y, Zhao X, Agarwal A, Mueller L J, Feng P Y 2010 J. Am. Chem. Soc. 132 1500

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    Ashley C E, Carnes E C, Phillips G K, Padilla D, Durfee P N, Brown P A, Hanna T N, Liu J W, Phillips B, Carter M B, Carroll N J, Jiang X M, Dunphy D R, Willman C L, Petsev D N, Evans D G, Parikh A N, Chackerian B, Wharton W, Peabody D S, Brinker C J 2011 Nature Materials 10 389

    [7]

    Rosenholm J M, Peuhu E, Eriksson J E, Sahlgren C, Lindén M 2009 Nano Lett. 9 3308

    [8]

    Liong M, Lu J, Kovochich M, Xia T, Ruehm S G, Nel A E, Tamanoi F, Zink J I 2008 ACS Nano. 2 889

    [9]

    Lei J M, L L, Liu L, Xu X L 2011 Acta Phys. Sin. 60 017501 (in Chinese) [雷洁梅, 吕柳, 刘玲, 许小亮 2011 物理学报 60 017501]

    [10]

    Kirchner C, Liedl T, Kudera S, Pellegrino T, Muñoz-Javier A, Gaub H E, Stölzle S, Fertig N, Parak W J 2005 Nano Lett. 5 2331

    [11]

    Cho E C, Xie J, Wurm P A, Xia Y 2009 Nano Lett. 9 1080

    [12]

    Arvizo R R, Miranda O R, Thompson M A, Pabelick C M, Bhattacharya R, Robertson J D, Rotello V M, Prakash Y S, Mukherjee P 2010 Nano Lett. 10 2543

    [13]

    Xia T, Kovochich M, Liong M, Zink J I, Nel A E 2008 ACS Nano. 2 85

    [14]

    Wilhelm C, Billotey C, Roger J, Pons J N, Bacri J C, Gazeau F 2003 Biomaterials 24 1001

    [15]

    Ryman-Rasmussen J P, Riviere J E, Monteiro-Riviere N A 2007 Nano Lett. 7 1344

    [16]

    Zhang X F, Yang S H 2011 Langmuir 27 2528

    [17]

    Rodahl M, Höök F, Fredriksson C, Keller C A, Krozer A, Brzezinski P, Voinova M, Kasemo B 1997 Faraday Discuss 107 229

    [18]

    Voinova M V, Jonson M, Kasemo B 2002 Biosensors and Bioelectronics 17 835

    [19]

    Richter R, Mukhopadhyay A, Brisson A 2003 Biophys. J 85 3035

    [20]

    Lu N Y, Yang K, Yuan B, Ma Y Q 2012 J. Phys. Chem. B 116 9432

    [21]

    Plant A L, Gueguechkeri M, Yap W 1994 Biophys. J. 67 1126

    [22]

    Plant A L 1999 Langmuir 15 5128

    [23]

    Jiang Z Y, Zhang G L, Ma J, Zhu T 2013 Acta Phys. Sin. 62 018701 (in Chinese) [蒋中英, 张国梁, 马晶, 朱涛 2013 物理学报 62 018701]

    [24]

    Möller K, Kobler J, Bein T 2007 Adv. Funct. Mater. 17 605

    [25]

    Kecht J, Schlossbauer A, Bein T 2008 Chem. Mater. 20 7207

    [26]

    Cauda V, Engelke H, Sauer A, Arcizet D, Bräuchle C, Rädler J, Bein T 2010 Nano Lett. 10 2484

    [27]

    Park C, Oh K, Lee S C, Kim C 2007 Angew. Chem. Int. Ed. 46 1455

    [28]

    Academic A U 1991 Nature 354 120

    [29]

    Diao P, Jiang D L, Cui X L, Gu D P, Tong R T, Zhong B 1999 Bioelectrochem. Bioenerg. 48 469

    [30]

    Ding L, Li J H, Dong S J, Wang E K 1996 J. Electroanal. Chem. 416 105

    [31]

    Tu C K, Chen K, Tian W D, Ma Y Q 2013 Macromol. Rapid Comm. 34 1237

    [32]

    Ding H M, Ma Y Q 2012 Biomaterials 33 5798

  • [1]

    Yousaf M Z, Yu J, Hou Y L, Gao S 2013 Chin. Phys. B 22 058702

    [2]

    Liu J W, Jiang X M, Ashley C, Brinker C J 2009 J. Am. Chem. Soc. 131 7567

    [3]

    Giri S, Trewyn B G, Stellmaker M P, Lin V S Y 2005 Angew. Chem. Int. Ed. 44 5038

    [4]

    Hong C Y, Li X, Pan C Y 2008 J. Phys. Chem. C 112 15320

    [5]

    Liu R, Zhang Y, Zhao X, Agarwal A, Mueller L J, Feng P Y 2010 J. Am. Chem. Soc. 132 1500

    [6]

    Ashley C E, Carnes E C, Phillips G K, Padilla D, Durfee P N, Brown P A, Hanna T N, Liu J W, Phillips B, Carter M B, Carroll N J, Jiang X M, Dunphy D R, Willman C L, Petsev D N, Evans D G, Parikh A N, Chackerian B, Wharton W, Peabody D S, Brinker C J 2011 Nature Materials 10 389

    [7]

    Rosenholm J M, Peuhu E, Eriksson J E, Sahlgren C, Lindén M 2009 Nano Lett. 9 3308

    [8]

    Liong M, Lu J, Kovochich M, Xia T, Ruehm S G, Nel A E, Tamanoi F, Zink J I 2008 ACS Nano. 2 889

    [9]

    Lei J M, L L, Liu L, Xu X L 2011 Acta Phys. Sin. 60 017501 (in Chinese) [雷洁梅, 吕柳, 刘玲, 许小亮 2011 物理学报 60 017501]

    [10]

    Kirchner C, Liedl T, Kudera S, Pellegrino T, Muñoz-Javier A, Gaub H E, Stölzle S, Fertig N, Parak W J 2005 Nano Lett. 5 2331

    [11]

    Cho E C, Xie J, Wurm P A, Xia Y 2009 Nano Lett. 9 1080

    [12]

    Arvizo R R, Miranda O R, Thompson M A, Pabelick C M, Bhattacharya R, Robertson J D, Rotello V M, Prakash Y S, Mukherjee P 2010 Nano Lett. 10 2543

    [13]

    Xia T, Kovochich M, Liong M, Zink J I, Nel A E 2008 ACS Nano. 2 85

    [14]

    Wilhelm C, Billotey C, Roger J, Pons J N, Bacri J C, Gazeau F 2003 Biomaterials 24 1001

    [15]

    Ryman-Rasmussen J P, Riviere J E, Monteiro-Riviere N A 2007 Nano Lett. 7 1344

    [16]

    Zhang X F, Yang S H 2011 Langmuir 27 2528

    [17]

    Rodahl M, Höök F, Fredriksson C, Keller C A, Krozer A, Brzezinski P, Voinova M, Kasemo B 1997 Faraday Discuss 107 229

    [18]

    Voinova M V, Jonson M, Kasemo B 2002 Biosensors and Bioelectronics 17 835

    [19]

    Richter R, Mukhopadhyay A, Brisson A 2003 Biophys. J 85 3035

    [20]

    Lu N Y, Yang K, Yuan B, Ma Y Q 2012 J. Phys. Chem. B 116 9432

    [21]

    Plant A L, Gueguechkeri M, Yap W 1994 Biophys. J. 67 1126

    [22]

    Plant A L 1999 Langmuir 15 5128

    [23]

    Jiang Z Y, Zhang G L, Ma J, Zhu T 2013 Acta Phys. Sin. 62 018701 (in Chinese) [蒋中英, 张国梁, 马晶, 朱涛 2013 物理学报 62 018701]

    [24]

    Möller K, Kobler J, Bein T 2007 Adv. Funct. Mater. 17 605

    [25]

    Kecht J, Schlossbauer A, Bein T 2008 Chem. Mater. 20 7207

    [26]

    Cauda V, Engelke H, Sauer A, Arcizet D, Bräuchle C, Rädler J, Bein T 2010 Nano Lett. 10 2484

    [27]

    Park C, Oh K, Lee S C, Kim C 2007 Angew. Chem. Int. Ed. 46 1455

    [28]

    Academic A U 1991 Nature 354 120

    [29]

    Diao P, Jiang D L, Cui X L, Gu D P, Tong R T, Zhong B 1999 Bioelectrochem. Bioenerg. 48 469

    [30]

    Ding L, Li J H, Dong S J, Wang E K 1996 J. Electroanal. Chem. 416 105

    [31]

    Tu C K, Chen K, Tian W D, Ma Y Q 2013 Macromol. Rapid Comm. 34 1237

    [32]

    Ding H M, Ma Y Q 2012 Biomaterials 33 5798

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  • Received Date:  19 April 2013
  • Accepted Date:  15 May 2013
  • Published Online:  05 September 2013

Nonspecific adsorption of charged mesoporous nanoparticles on supported thiol/lipid hybrid bilayers

  • 1. National Laboratory of Solid State Microstructures and Department of Physics, Nanjing University, Nanjing 210093, China;
  • 2. Center for Soft Condensed Matter Physics and Interdisciplinary Research, Soochow University, Suzhou 215006, China
Fund Project:  Project supported by the National Natural Science Foundation of China (Grant Nos. 11104192, 21106114), the Key Project of Chinese Ministry of Education, China (Grant No. 210208), and the Applied Basic Research Program of Yunnan Province, China (Grant No. 2010CD091).

Abstract: Mesoporous silica nanoparticles (MSN) with cationic and anionic surface charges were synthesized, Their adsorption behaviors to the supported lipid membranes at different pH values were also studied using QCM-D. We found that NH2-MSN could be adsorbed onto the membrane at pH values from 4 to 8, while the adsorption of COOH-MSN onto the membrane could not occur due to its charge being always the same as that of the membrane at any pH values. These results might provide the information for understanding and predicting the interactions between nanoparticles and cell membranes, and could be effectively used in drug delivery systems and disease treatment.

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