In this work, the vibrational energy transfer of organic molecule CH2C12 was studied with laser induced fluorescence method for the first time. The activation and deactiva-tion rate constants of modes ν3 and ν3/ν9 of pure CH2C12, as well as the effect of rare gases on the deactivation processes for ν3/ν9, were obtained. The relative propablities of energy transfer from ν3/ν9 vibrational modes of CH2Cl2 to translational degree of freedom were calculated by means of SSH theory for the collision relaxation processes of CH2Cl2-rare gas mixtures. A vibrational energy transfer channel in CH2C12 is also discussed.