生物医学微波热声成像

王雨; 张慧敏; 覃欢

doi:10.7498/aps.72.20230732

摘要

微波热声成像是一种以生物组织电特性差异为原理基础的多物理场耦合成像方法. 其采用脉冲微波作为激发源, 通过热弹性效应产生的超声波呈递深层生物组织的结构与功能信息, 融合了微波成像高对比度和超声成像高分辨率的优点. 目前已在无损脑结构成像、乳腺肿瘤筛查、人体关节炎成像、肝脂肪含量检测等方面展现出了广阔的医学应用前景, 有望成为新的物理医学影像方法. 本文对微波热声成像技术的物理原理、系统装置以及近来的代表性研究进展进行了系统性的介绍, 并分析探讨了微波热声成像技术值得关注的发展方向以及面临的挑战.

关键词:

Abstract

Microwave thermoacoustic imaging (MTAI) is an exciting imaging technique rooted from the underlying principle of exploiting the distinct electrical properties of biological tissues. By using short-pulsed microwaves as a stimulation source and their interaction with the human body, MTAI has paved the way for revolutionary advancements in medical imaging. When microwaves are absorbed by polar molecules and ions within the tissues, an ingenious thermoelastic effect gives rise to ultrasound waves. These ultrasound waves, brimming with invaluable pathological and physiological insights, propagate outward, carrying the essence of the composition and functionality of biological tissue. Through a meticulous collection of ultrasound signals from all directions surrounding the tissue, it becomes possible to reconstruct intricate internal structures and visualize the tissue's functional dynamics. The MTAI excels in non-invasiveness, capable of delving several centimeters beneath the surface with a microscopic resolution on the order of micrometers. The magic lies in converting microwave energy into ultrasound waves, entering into the hidden depths of tissues without causing harm. This groundbreaking imaging modality unlocks a realm of possibilities for acquiring profound insights into the intricate structures and functionality of deep-seated tissues. Furthermore, the inherent polarization characteristics of microwaves empower MTAI to capture additional dimensions of information, unraveling the intricate polarization properties and illuminating a richer understanding of the tissue's complexity. The great potential of MTAI extends far and wide within the medicine field. It has made remarkable achievements in non-invasive imaging of brain structures, screening breast tumors, visualizing human arthritis, and detecting liver fat content. These accomplishments have laid a solid foundation, firmly establishing MTAI as a trailblazing medical imaging technique. The present study offers a comprehensive and in-depth exploration of the physical principles underpinning MTAI, the sophisticated system devices involved, and the recent groundbreaking research breakthroughs. Moreover, it delves into the exciting prospects and challenges that lie ahead in the future development of MTAI. As the technology continues to progress by leaps and bounds, MTAI is ready to break down barriers, and usher in a new era of unmatched imaging quality and performance. This, in turn, will open the floodgates for transformative innovations and applications in medical diagnosis and treatment. The anticipation is palpable as MTAI strives to make substantial contributions to the ever-developing medical imaging field, bestowing upon humanity more accurate, reliable, and life-enhancing diagnostic capabilities.

Keywords:

microwave-induced thermoacoustic imaging /
electrical properties of biological tissues /
microwave sources /
technique of brain imaging

作者及机构信息

1.
华南师范大学, 激光生命科学教育部重点实验室, 广州　510631

2.
华南师范大学, 广东省激光生命科学重点实验室, 广州　510631

3.
华南师范大学, 广州市光谱分析与功能探针重点实验室, 广州　510631

4.
华南师范大学生物光子学研究院, 广州　510631

通信作者: 覃欢, qinghuan@scnu.edu.cn

基金项目: 国家自然科学基金(批准号: 62075066 )、广东省基础与应用基础研究基金(批准号: 2023A1515010824)和广州市科技计划(批准号: 202201010718)资助的课题.

Authors and contacts

1.
Key Laboratory of Laser Life Science & Institute of Laser Life Science, Ministry of Education,South China Normal University, Guangzhou 510631, China

2.
Guangdong Provincial Key Laboratory of Laser Life Science, South China Normal University, Guangzhou 510631, China

3.
Guangzhou Key Laboratory of Spectral Analysis and Functional Probes, South China Normal University, Guangzhou 510631, China

4.
College of Biophotonics, South China Normal University, Guangzhou 510631, China

Corresponding author: Qin Huan, qinghuan@scnu.edu.cn

Funds: Project supported by the National Natural Science Foundation of China (Grant No. 62075066), the Basic and Applied Basic Research Foundation of Guangdong Province, China (Grant No. 2023A1515010824), and the Science and Technology Program of Guangzhou, China (Grant No. 202201010718).

文章全文 : translate this paragraph

参考文献

[1]	Ketcham R A, Carlson W D 2001 Comput. Geosci. 27 381 Google Scholar
[2]	Bushong S C, Clarke G 2003 Magnetic Resonance Imaging: Physical and Biological Principles (Amsterdam: Elsevier Health Sciences) pp58–65
[3]	Bushberg J T, Boone J M 2011 The Essential Physics of Medical Imaging (Philadelphia: Lippincott Williams & Wilkins) pp171–202
[4]	Haribabu V, Girigoswami K, Sharmiladevi P, Girigoswami A 2020 ACS Biomater. Sci. Eng. 6 4377 Google Scholar
[5]	Chan V, Perlas A 2011 Atlas of Ultrasound-guided Procedures in Interventional Pain Management (New York: Springer) p13
[6]	Nguyen K C T, Le L H, Kaipatur N R, Zheng R, Lou E H, Major P W 2016 Ann. Biomed. Eng. 44 2874 Google Scholar
[7]	Wang H, Liu N 2020 J. Med. Imaging Health Inf. 10 918 Google Scholar
[8]	Xu M H, Ku G, Jin X, Wang L V, Fornage B D, Hunt K K 2005 The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics 5697 45
[9]	Behari J 2019 Radio Frequency and Microwave Effects on Biological Tissues (New York: CRC Press) pp63–82
[10]	Chen H, Tang X, Nie G, Wang Z, Hu J, Hu J, Qin H 2023 J. Innovative Opt. Health Sci. 16 2243002 Google Scholar
[11]	Lin J C 2005 Advances in Electromagnetic Fields in Living Systems (Boston: Springer) p41
[12]	Zhao S X, Wang H H, Li Y J, Nie L M, Zhang S X, Xing D, Qin H 2021 IEEE Trans. Biomed. Eng. 69 725
[13]	Rahpeima R, Soltani M, Kashkooli F M 2020 Comput. Methods Programs Biomed. 196 105606 Google Scholar
[14]	Liu Q, Liang X, Li T, Chao W, Qi W Z, Jin T, Gong Y, Jiang H B, Xi L 2023 IEEE Trans. Med. Imaging 42 2425
[15]	Zhao Y, Shan T, Chi Z H, Jiang H B 2020 J. Xray Sci. Technol. 28 83
[16]	Ren M Y, Cheng Z W, Wu L H, et al. 2023 IEEE Trans. Biomed. Eng. 70 175 Google Scholar
[17]	Chi Z H, Huang L, Wu D, Long X J, Xu X L, Jiang H B 2022 Med. Phys. 49 84 Google Scholar
[18]	Vander Vorst A, Rosen A, Kotsuka Y 2006 RF/microwave Interaction With Biological Tissues (Hoboken: John Wiley & Sons) pp30–38
[19]	Schwan H P, Foster K R 1980 Proc. IEEE 68 104 Google Scholar
[20]	Foster K R, Schwan H P 2019 CRC Handbook of Biological Effects of Electromagnetic Fields (Boca Raton: CRC press) pp27–76
[21]	Fiedler T M, Ladd M E, Bitz A K 2018 Neuroimage 168 33 Google Scholar
[22]	Williams J M 2001 arXiv: 0102007 [physics.gen-ph
[23]	Bacon C, Guilliorit E, Hosten B, Chimenti D E 2001 J. Acoust. Soc. Am. 110 1398 Google Scholar
[24]	Dagro A M, Wilkerson J W, Thomas T P, Kalinosky B T, Payne J A 2021 Sci. Adv. 7 eabd8405 Google Scholar
[25]	Zhang X C, Xu J 2010 Introduction to THz Wave Photonics (Vol. 29) (New York: Springer) pp70–82
[26]	Drain L 2019 Laser Ultrasonics: Techniques and Applications (New York: Routledge) pp305–322
[27]	Paltauf G, Dyer P E 2003 Chem. Rev. 103 487 Google Scholar
[28]	Harris C M, Piersol A G 2002 Harris’ Shock and Vibration Handbook (Vol. 5) (New York: McGraw-Hill) p21
[29]	Drebushchak V 2020 J. Therm. Anal. Calorim. 142 1097 Google Scholar
[30]	Gao F, Zheng Q, Zheng Y J 2014 Med. Phys. 41 053302 Google Scholar
[31]	Luo W L, Ji Z, Yang S H, Xing D 2018 Phys. Rev. Appl. 10 1728
[32]	Lou C G, Yang S H, Ji Z, Chen Q, Xing D 2012 Phys. Rev. Lett. 109 218101 Google Scholar
[33]	Ji Z, Lou C G, Yang S H, Xing D 2012 Med. Phys. 39 6738 Google Scholar
[34]	Yan J, Tao C J, Wu S Z 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference Shanghai, China, 17–18 January 2006 p1521
[35]	Lou C G, Nie L M, Xu D 2011 J. Appl. Phys. 110 083101 Google Scholar
[36]	Ji Z, Ding W Z, Ye F H, Lou C G, Xing D 2015 Appl. Phys. Lett. 107 094104 Google Scholar
[37]	Ji Z, Lou C G, Shi Y, Ding W Z, Yang S H, Xing D 2015 Appl. Phys. Lett. 107 839
[38]	Wang X, Bauer D R, Vollin J L, Manzi D G, Witte R S, Xin H 2012 IEEE Antennas Wirel. Propag. Lett. 11 1634 Google Scholar
[39]	Sharif-Khodaei Z, Aliabadi M 2014 Smart Mater. Struct. 23 075007 Google Scholar
[40]	Berger C R, Demissie B, Heckenbach J, Willett P, Zhou S 2010 IEEE J. Sel. Top. Sign. Proces. 4 226 Google Scholar
[41]	Li J, Wu R B 1998 IEEE Trans. Sign. Proces. 46 2231 Google Scholar
[42]	Xu Q W, Zheng Z, Jiang H B 2021 Chin. Phys. B 30 024302 Google Scholar
[43]	Zhang J L, Li C Z, Jiang W C, Wang Z C, Zhang L J, Wang X 2022 IEEE Trans. Antennas Propag. 70 6336 Google Scholar
[44]	Li C Z, Xi Z J, Jin G F, Jiang W C, Wang B S, Cai X R, Wang X 2023 IEEE Trans. Biomed. Eng. 70 2350 Google Scholar
[45]	Wang B S, Sun Y F, Wang Z C, Wang X 2020 IEEE Trans. Microwave Theory Tech. 68 377 Google Scholar
[46]	Yu L, Antoni J, Wu H, Leclere Q, Jiang W 2019 Mech. Syst. Sig. Process. 134 106309 Google Scholar
[47]	Song J, Shen T, Wang Q W 2022 IEEE J. Electromagn. RF Microwaves Med. Biol. 7 59
[48]	Luo Z X, Li C Z, Liu D T, Wang B S, Zhang L J, Ma Y X, Xu K W, Wang X 2023 IEEE Trans. Microwave Theory Tech. 71 2652 Google Scholar
[49]	Huang L, Rong J, Yao L, Qi W Z, Wu D, Xu J Y, Jiang H B 2013 Chin. Phys. Lett. 30 124301 Google Scholar
[50]	Nie L M, Xing D, Zhou Q, Yang D W, Guo H 2008 Med. Phys. 35 4026 Google Scholar
[51]	Huang L, Zheng Z, Chi Z H, Jiang H B 2021 Med. Phys. 48 4242 Google Scholar
[52]	Ku G, Wang L V 2001 Med. Phys. 28 4 Google Scholar
[53]	Liang X, Guo H, Liu Q, Wu C F, Gong Y B, Xi L 2020 Appl. Phys. Lett. 116 013702 Google Scholar
[54]	Fu Y, Ji Z, Ding W Z, Ye F H, Lou C G 2014 Med. Phys. 41 110701 Google Scholar
[55]	Ding W Z, Ji Z, Ye F H, Lou C G, Xing D 2015 IEEE Trans. Microwave Theory Tech. 63 3272 Google Scholar
[56]	Volmer C, Weber J, Stephan R, Blau K, Hein M A 2008 IEEE Trans. Antennas Propag. 56 360 Google Scholar
[57]	Nan H, Arbabian A 2017 IEEE Trans. Microwave Theory Tech. 65 2607 Google Scholar
[58]	Ku G, Wang L V 2000 Med. Phys. 27 1195 Google Scholar
[59]	Xu M H, Xu Y, Wang L V 2003 IEEE Trans. Biomed. Eng. 50 1086 Google Scholar
[60]	Xu M H, Wang L V 2002 IEEE Trans. Med. Imaging 21 814 Google Scholar
[61]	Zhao Z Q, Song J, Zhu X Z, Wang J G, Wu J N, Liu Y L, Nie Z P, Liu Q H 2012 Electromagn. Waves 134 323
[62]	Cannata J M, Ritter T A, Chen W H, Silverman R H, Shung K K 2003 IEEE Trans. Ultrason. Ferroelectr. Freq. Control 50 1548 Google Scholar
[63]	Sun X L, Yang X C, Zhu X Y, Liu H H 2017 IEEE Sens. J. 18 1373
[64]	Li Z X, Chen D D, Fei C L, Li D, Feng W, Yang Y T 2021 IEEE Trans. Ultrason. Ferroelectr. Freq. Control 68 2202 Google Scholar
[65]	Candès E J, Wakin M B 2008 IEEE Signal Process Mag. 25 21 Google Scholar
[66]	Ye F H, Ji Z, Ding W Z, Lou C G, Yang S H, Xing D 2016 IEEE Trans. Med. Imaging 35 839 Google Scholar
[67]	Chia S K, Speers C H, D’yachkova Y, Kang A, Malfair‐Taylor S, Barnett J, Coldman A, Gelmon K A, O’reilly S E, Olivotto I A 2007 Cancer 110 973 Google Scholar
[68]	Youlden D R, Cramb S M, Dunn N A, Muller J M, Pyke C M, Baade P D 2012 Cancer Epidemiol. 36 237 Google Scholar
[69]	Verkman A, Hara-Chikuma M, Papadopoulos M C 2008 J. Mol. Med. 86 523 Google Scholar
[70]	Yu C H, Tang W, Wang Y H, Shen Q, Wang B, Cai C Q, Meng X J, Zou F 2016 Cancer Lett. 376 268 Google Scholar
[71]	Baritaki S, Apostolakis S, Kanellou P, Dimanche‐Boitrel M T, Spandidos D A, Bonavida B 2007 Adv. Cancer Res. 98 149
[72]	Li X, Davis S K, Hagness S C, Van der Weide D W, Van Veen B D 2004 IEEE Trans. Microwave Theory Tech. 52 1856 Google Scholar
[73]	Celik A R, Kurt M B, Helhel S 2019 ACES 34 1549
[74]	Kruger R A, Miller K D, Reynolds H E, Kiser Jr W L, Reinecke D R, Kruger G A 2000 Radiology 216 279 Google Scholar
[75]	Wu L H, Cheng Z W, Ma Y Z, Li Y J, Ren M Y, Xing D, Qin H 2022 IEEE Trans. Med. Imaging 41 1080 Google Scholar
[76]	Huang Y, Omar M, Tian W, Lopez-Schier H, Westmeyer G G, Chmyrov A, Sergiadis G, Ntziachristos V 2021 Sci. Adv. 7 eabd1505 Google Scholar
[77]	Joines W T, Jirtle R L, Rafal M D, Schaefer D J 1980 Inte. J. Radiat. Oncol. Biol. Phys. 6 681 Google Scholar
[78]	Zheng Z, Jiang Y C, Huang L, Zhao Y, Jiang H B 2020 J. X-Ray Sci. Technol. 28 137
[79]	Zhao Y, Chi Z H, Huang L, Zheng Z, Yang J G, Jiang H B 2017 J. Innovative Opt. Health Sci. 10 1740001 Google Scholar
[80]	Cunningham L S, Kelsey J L 1984 Am. J. Public Health 74 574 Google Scholar
[81]	Tański W, Dudek K, Tomasiewicz A, Świątoniowska-Lonc N 2022 Int. J. Environ. Res. Public Health 19 3088 Google Scholar
[82]	Gadeval A, Chaudhari S, Bollampally S P, et al. 2021 Drug Discovery Today 26 2315 Google Scholar
[83]	Thornton G, Shrive N, Frank C 2001 J. Orthop. Res. 19 845 Google Scholar
[84]	Buckwalter J A, Mow V C, Ratcliffe A 1994 JAAOS-J. Am. Acad. Orthopaedic Surgeons 2 192 Google Scholar
[85]	Sultan K S, Mohammed B, Manoufali M, Abbosh A M 2021 IEEE Trans. Antennas Propag. 69 6824 Google Scholar
[86]	Chi Z H, Zhao Y, Huang L, Zheng Z, Jiang H B 2016 Med. Phys. 43 6226 Google Scholar
[87]	Chi Z H, Zhao Y, Yang J G, Li T T, Zhang G, Jiang H B 2019 IEEE Trans. Biomed. Eng. 66 1598 Google Scholar
[88]	Gandhi M S, Kamalov G, Shahbaz A U, Bhattacharya S K, Ahokas R A, Sun Y, Gerling I C, Weber K T 2011 Heart Fail. Rev. 16 23 Google Scholar
[89]	Weber K T, Sun Y, Bhattacharya S K, Ahokas R A, Gerling I C 2013 Nat. Rev. Cardiol. 10 15 Google Scholar
[90]	Friedberg C K, Horn H 1939 J. Am. Med. Assoc. 112 1675 Google Scholar
[91]	Smit M, Coetzee A, Lochner A 2020 J. Cardiothorac. Vasc. Anesth. 34 2501 Google Scholar
[92]	Alpert J S 1989 Cardiology 76 85 Google Scholar
[93]	Li Y J, Zhang S X, Wu L H, et al. 2022 Photonics Res. 10 1297 Google Scholar

施引文献

图 1 热声效应示意图

Fig. 1. Schematic diagram of TA effect.

下载: 全尺寸图片幻灯片

图 2 微波热声信号延时叠加算法示意图

Fig. 2. Schematic diagram of the thermoacoustic signal delay superposition algorithm.

下载: 全尺寸图片幻灯片

图 3 微波热声成像技术典型实现方案　(a)微波乳腺热声成像一体化探头装置图^[16]; (b)微波热声脑成像装置图^[15]; (c)微波乳腺热声成像装置^[66]; (d)微波热声关节成像装置图^[17]

Fig. 3. Typical implementation scheme of microwave thermoacoustic imaging technology: (a) Microwave-induced breast thermoacoustic imaging integrated probe device^[16]; (b) diagram of a Microwave-induced brain thermoacoustic imaging device^[15]; (c) microwave-induced breast thermoacoustic imaging system^[66]; (d) microwave-induced thermoacoustic joint imaging device^[17].

下载: 全尺寸图片幻灯片

图 4 微波热声成像乳腺成像　(a) Kruger等^[74]的乳腺成像图; (b) 微波热声乳腺成像实操图^[16]; (c) 乳房的解剖结构示意图^[16]; (d) 覃欢团队^[16]乳腺成像图

Fig. 4. MTAI breast imaging: (a) Kruger et al.^[74] breast imaging; (b) microwave thermoacoustic breast imaging actual operation diagram^[16]; (c) anatomical diagram of the breast^[16]; (d) breast imaging of Professor Qin Huan’s team^[16].

下载: 全尺寸图片幻灯片

图 5 微波热声脑成像^[15]　(a) 两只新生小鼠脑出血的热声图像及出血区域标注(白色区域); (b) 脑出血组织切片与相应热声图像对照

Fig. 5. MTAI brain imaging^[15]: (a) MTAI image and bleeding area (white area) of cerebral hemorrhage in two newborn mice; (b) comparison of cerebral hemorrhage tissue slices with corresponding MTAI images.

下载: 全尺寸图片幻灯片

图 6 受试者中指的热声图像 (T0-T30)和MRI (M2-M30)的比较^[17]

Fig. 6. Comparison of MTAI (T0-T30) and MRI (M2-M30) of subjects’ middle fingers^[17].

下载: 全尺寸图片幻灯片

图 7 偏振微波热声心梗模型成像^[93]　(a) 偏振微波热声成像系统的示意图和用于计算异质性参数(DOMA)的偏振微波热声成像机制; (b) 超声图像及相应的DOMA图像

Fig. 7. P-MTAI myocardial infarction model detection^[93]: (a) Schematic diagram of the P-MTAI imaging system and the P-MTAI mechanism used to calculate DOMA; (b) ultrasonic images and corresponding DOMA images.

下载: 全尺寸图片幻灯片

表 1 微波源各参数对成像影响

Table 1. Influence of various parameters of microwave source on imaging.

成像影响	微波源参数
分辨率	脉冲宽度、脉冲波形
信噪比	脉冲重复频率、脉冲能量强度
对比度	中心频率、脉冲能量强度
成像深度	中心频率、脉冲能量强度

下载: 导出CSV

表 2 主要脑组织在3.05 GHz下的电导率^[15]

Table 2. Conductivity property of major brain tissues at 3.05 GHz^[15].

物质	电导率/(S·m^–1)
脑灰质	2.2588
脑白质	1.5393
血液	3.0991
脑脊液	4.0592
小脑	2.5189
血管壁	1.8444
硬膜	2.0485
脊髓	1.3530

下载: 导出CSV

表 3 关节各组织在3 GHz下的电导率和介电常数^[85]

Table 3. Conductivity and permittivity of each tissue of the joint at 3 GHz^[85].

物质	相对介电常数	电导率/(S·m^–1)
肌腱/韧带	42.13	2.17
软骨	37.61	2.21
骨松质	17.94	1.01

下载: 导出CSV

[1]	Ketcham R A, Carlson W D 2001 Comput. Geosci. 27 381 Google Scholar
[2]	Bushong S C, Clarke G 2003 Magnetic Resonance Imaging: Physical and Biological Principles (Amsterdam: Elsevier Health Sciences) pp58–65
[3]	Bushberg J T, Boone J M 2011 The Essential Physics of Medical Imaging (Philadelphia: Lippincott Williams & Wilkins) pp171–202
[4]	Haribabu V, Girigoswami K, Sharmiladevi P, Girigoswami A 2020 ACS Biomater. Sci. Eng. 6 4377 Google Scholar
[5]	Chan V, Perlas A 2011 Atlas of Ultrasound-guided Procedures in Interventional Pain Management (New York: Springer) p13
[6]	Nguyen K C T, Le L H, Kaipatur N R, Zheng R, Lou E H, Major P W 2016 Ann. Biomed. Eng. 44 2874 Google Scholar
[7]	Wang H, Liu N 2020 J. Med. Imaging Health Inf. 10 918 Google Scholar
[8]	Xu M H, Ku G, Jin X, Wang L V, Fornage B D, Hunt K K 2005 The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics 5697 45
[9]	Behari J 2019 Radio Frequency and Microwave Effects on Biological Tissues (New York: CRC Press) pp63–82
[10]	Chen H, Tang X, Nie G, Wang Z, Hu J, Hu J, Qin H 2023 J. Innovative Opt. Health Sci. 16 2243002 Google Scholar
[11]	Lin J C 2005 Advances in Electromagnetic Fields in Living Systems (Boston: Springer) p41
[12]	Zhao S X, Wang H H, Li Y J, Nie L M, Zhang S X, Xing D, Qin H 2021 IEEE Trans. Biomed. Eng. 69 725
[13]	Rahpeima R, Soltani M, Kashkooli F M 2020 Comput. Methods Programs Biomed. 196 105606 Google Scholar
[14]	Liu Q, Liang X, Li T, Chao W, Qi W Z, Jin T, Gong Y, Jiang H B, Xi L 2023 IEEE Trans. Med. Imaging 42 2425
[15]	Zhao Y, Shan T, Chi Z H, Jiang H B 2020 J. Xray Sci. Technol. 28 83
[16]	Ren M Y, Cheng Z W, Wu L H, et al. 2023 IEEE Trans. Biomed. Eng. 70 175 Google Scholar
[17]	Chi Z H, Huang L, Wu D, Long X J, Xu X L, Jiang H B 2022 Med. Phys. 49 84 Google Scholar
[18]	Vander Vorst A, Rosen A, Kotsuka Y 2006 RF/microwave Interaction With Biological Tissues (Hoboken: John Wiley & Sons) pp30–38
[19]	Schwan H P, Foster K R 1980 Proc. IEEE 68 104 Google Scholar
[20]	Foster K R, Schwan H P 2019 CRC Handbook of Biological Effects of Electromagnetic Fields (Boca Raton: CRC press) pp27–76
[21]	Fiedler T M, Ladd M E, Bitz A K 2018 Neuroimage 168 33 Google Scholar
[22]	Williams J M 2001 arXiv: 0102007 [physics.gen-ph
[23]	Bacon C, Guilliorit E, Hosten B, Chimenti D E 2001 J. Acoust. Soc. Am. 110 1398 Google Scholar
[24]	Dagro A M, Wilkerson J W, Thomas T P, Kalinosky B T, Payne J A 2021 Sci. Adv. 7 eabd8405 Google Scholar
[25]	Zhang X C, Xu J 2010 Introduction to THz Wave Photonics (Vol. 29) (New York: Springer) pp70–82
[26]	Drain L 2019 Laser Ultrasonics: Techniques and Applications (New York: Routledge) pp305–322
[27]	Paltauf G, Dyer P E 2003 Chem. Rev. 103 487 Google Scholar
[28]	Harris C M, Piersol A G 2002 Harris’ Shock and Vibration Handbook (Vol. 5) (New York: McGraw-Hill) p21
[29]	Drebushchak V 2020 J. Therm. Anal. Calorim. 142 1097 Google Scholar
[30]	Gao F, Zheng Q, Zheng Y J 2014 Med. Phys. 41 053302 Google Scholar
[31]	Luo W L, Ji Z, Yang S H, Xing D 2018 Phys. Rev. Appl. 10 1728
[32]	Lou C G, Yang S H, Ji Z, Chen Q, Xing D 2012 Phys. Rev. Lett. 109 218101 Google Scholar
[33]	Ji Z, Lou C G, Yang S H, Xing D 2012 Med. Phys. 39 6738 Google Scholar
[34]	Yan J, Tao C J, Wu S Z 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference Shanghai, China, 17–18 January 2006 p1521
[35]	Lou C G, Nie L M, Xu D 2011 J. Appl. Phys. 110 083101 Google Scholar
[36]	Ji Z, Ding W Z, Ye F H, Lou C G, Xing D 2015 Appl. Phys. Lett. 107 094104 Google Scholar
[37]	Ji Z, Lou C G, Shi Y, Ding W Z, Yang S H, Xing D 2015 Appl. Phys. Lett. 107 839
[38]	Wang X, Bauer D R, Vollin J L, Manzi D G, Witte R S, Xin H 2012 IEEE Antennas Wirel. Propag. Lett. 11 1634 Google Scholar
[39]	Sharif-Khodaei Z, Aliabadi M 2014 Smart Mater. Struct. 23 075007 Google Scholar
[40]	Berger C R, Demissie B, Heckenbach J, Willett P, Zhou S 2010 IEEE J. Sel. Top. Sign. Proces. 4 226 Google Scholar
[41]	Li J, Wu R B 1998 IEEE Trans. Sign. Proces. 46 2231 Google Scholar
[42]	Xu Q W, Zheng Z, Jiang H B 2021 Chin. Phys. B 30 024302 Google Scholar
[43]	Zhang J L, Li C Z, Jiang W C, Wang Z C, Zhang L J, Wang X 2022 IEEE Trans. Antennas Propag. 70 6336 Google Scholar
[44]	Li C Z, Xi Z J, Jin G F, Jiang W C, Wang B S, Cai X R, Wang X 2023 IEEE Trans. Biomed. Eng. 70 2350 Google Scholar
[45]	Wang B S, Sun Y F, Wang Z C, Wang X 2020 IEEE Trans. Microwave Theory Tech. 68 377 Google Scholar
[46]	Yu L, Antoni J, Wu H, Leclere Q, Jiang W 2019 Mech. Syst. Sig. Process. 134 106309 Google Scholar
[47]	Song J, Shen T, Wang Q W 2022 IEEE J. Electromagn. RF Microwaves Med. Biol. 7 59
[48]	Luo Z X, Li C Z, Liu D T, Wang B S, Zhang L J, Ma Y X, Xu K W, Wang X 2023 IEEE Trans. Microwave Theory Tech. 71 2652 Google Scholar
[49]	Huang L, Rong J, Yao L, Qi W Z, Wu D, Xu J Y, Jiang H B 2013 Chin. Phys. Lett. 30 124301 Google Scholar
[50]	Nie L M, Xing D, Zhou Q, Yang D W, Guo H 2008 Med. Phys. 35 4026 Google Scholar
[51]	Huang L, Zheng Z, Chi Z H, Jiang H B 2021 Med. Phys. 48 4242 Google Scholar
[52]	Ku G, Wang L V 2001 Med. Phys. 28 4 Google Scholar
[53]	Liang X, Guo H, Liu Q, Wu C F, Gong Y B, Xi L 2020 Appl. Phys. Lett. 116 013702 Google Scholar
[54]	Fu Y, Ji Z, Ding W Z, Ye F H, Lou C G 2014 Med. Phys. 41 110701 Google Scholar
[55]	Ding W Z, Ji Z, Ye F H, Lou C G, Xing D 2015 IEEE Trans. Microwave Theory Tech. 63 3272 Google Scholar
[56]	Volmer C, Weber J, Stephan R, Blau K, Hein M A 2008 IEEE Trans. Antennas Propag. 56 360 Google Scholar
[57]	Nan H, Arbabian A 2017 IEEE Trans. Microwave Theory Tech. 65 2607 Google Scholar
[58]	Ku G, Wang L V 2000 Med. Phys. 27 1195 Google Scholar
[59]	Xu M H, Xu Y, Wang L V 2003 IEEE Trans. Biomed. Eng. 50 1086 Google Scholar
[60]	Xu M H, Wang L V 2002 IEEE Trans. Med. Imaging 21 814 Google Scholar
[61]	Zhao Z Q, Song J, Zhu X Z, Wang J G, Wu J N, Liu Y L, Nie Z P, Liu Q H 2012 Electromagn. Waves 134 323
[62]	Cannata J M, Ritter T A, Chen W H, Silverman R H, Shung K K 2003 IEEE Trans. Ultrason. Ferroelectr. Freq. Control 50 1548 Google Scholar
[63]	Sun X L, Yang X C, Zhu X Y, Liu H H 2017 IEEE Sens. J. 18 1373
[64]	Li Z X, Chen D D, Fei C L, Li D, Feng W, Yang Y T 2021 IEEE Trans. Ultrason. Ferroelectr. Freq. Control 68 2202 Google Scholar
[65]	Candès E J, Wakin M B 2008 IEEE Signal Process Mag. 25 21 Google Scholar
[66]	Ye F H, Ji Z, Ding W Z, Lou C G, Yang S H, Xing D 2016 IEEE Trans. Med. Imaging 35 839 Google Scholar
[67]	Chia S K, Speers C H, D’yachkova Y, Kang A, Malfair‐Taylor S, Barnett J, Coldman A, Gelmon K A, O’reilly S E, Olivotto I A 2007 Cancer 110 973 Google Scholar
[68]	Youlden D R, Cramb S M, Dunn N A, Muller J M, Pyke C M, Baade P D 2012 Cancer Epidemiol. 36 237 Google Scholar
[69]	Verkman A, Hara-Chikuma M, Papadopoulos M C 2008 J. Mol. Med. 86 523 Google Scholar
[70]	Yu C H, Tang W, Wang Y H, Shen Q, Wang B, Cai C Q, Meng X J, Zou F 2016 Cancer Lett. 376 268 Google Scholar
[71]	Baritaki S, Apostolakis S, Kanellou P, Dimanche‐Boitrel M T, Spandidos D A, Bonavida B 2007 Adv. Cancer Res. 98 149
[72]	Li X, Davis S K, Hagness S C, Van der Weide D W, Van Veen B D 2004 IEEE Trans. Microwave Theory Tech. 52 1856 Google Scholar
[73]	Celik A R, Kurt M B, Helhel S 2019 ACES 34 1549
[74]	Kruger R A, Miller K D, Reynolds H E, Kiser Jr W L, Reinecke D R, Kruger G A 2000 Radiology 216 279 Google Scholar
[75]	Wu L H, Cheng Z W, Ma Y Z, Li Y J, Ren M Y, Xing D, Qin H 2022 IEEE Trans. Med. Imaging 41 1080 Google Scholar
[76]	Huang Y, Omar M, Tian W, Lopez-Schier H, Westmeyer G G, Chmyrov A, Sergiadis G, Ntziachristos V 2021 Sci. Adv. 7 eabd1505 Google Scholar
[77]	Joines W T, Jirtle R L, Rafal M D, Schaefer D J 1980 Inte. J. Radiat. Oncol. Biol. Phys. 6 681 Google Scholar
[78]	Zheng Z, Jiang Y C, Huang L, Zhao Y, Jiang H B 2020 J. X-Ray Sci. Technol. 28 137
[79]	Zhao Y, Chi Z H, Huang L, Zheng Z, Yang J G, Jiang H B 2017 J. Innovative Opt. Health Sci. 10 1740001 Google Scholar
[80]	Cunningham L S, Kelsey J L 1984 Am. J. Public Health 74 574 Google Scholar
[81]	Tański W, Dudek K, Tomasiewicz A, Świątoniowska-Lonc N 2022 Int. J. Environ. Res. Public Health 19 3088 Google Scholar
[82]	Gadeval A, Chaudhari S, Bollampally S P, et al. 2021 Drug Discovery Today 26 2315 Google Scholar
[83]	Thornton G, Shrive N, Frank C 2001 J. Orthop. Res. 19 845 Google Scholar
[84]	Buckwalter J A, Mow V C, Ratcliffe A 1994 JAAOS-J. Am. Acad. Orthopaedic Surgeons 2 192 Google Scholar
[85]	Sultan K S, Mohammed B, Manoufali M, Abbosh A M 2021 IEEE Trans. Antennas Propag. 69 6824 Google Scholar
[86]	Chi Z H, Zhao Y, Huang L, Zheng Z, Jiang H B 2016 Med. Phys. 43 6226 Google Scholar
[87]	Chi Z H, Zhao Y, Yang J G, Li T T, Zhang G, Jiang H B 2019 IEEE Trans. Biomed. Eng. 66 1598 Google Scholar
[88]	Gandhi M S, Kamalov G, Shahbaz A U, Bhattacharya S K, Ahokas R A, Sun Y, Gerling I C, Weber K T 2011 Heart Fail. Rev. 16 23 Google Scholar
[89]	Weber K T, Sun Y, Bhattacharya S K, Ahokas R A, Gerling I C 2013 Nat. Rev. Cardiol. 10 15 Google Scholar
[90]	Friedberg C K, Horn H 1939 J. Am. Med. Assoc. 112 1675 Google Scholar
[91]	Smit M, Coetzee A, Lochner A 2020 J. Cardiothorac. Vasc. Anesth. 34 2501 Google Scholar
[92]	Alpert J S 1989 Cardiology 76 85 Google Scholar
[93]	Li Y J, Zhang S X, Wu L H, et al. 2022 Photonics Res. 10 1297 Google Scholar

[1]	张嘉禧, 李凌峰, 钟洪文, 肖嘉莹. 用于深层组织分子成像的小型化光声/超声内窥成像探头. 物理学报, 2024, 73(21): 214203. doi: 10.7498/aps.73.20241076
[2]	尹鸿润, 叶明, 吴阳, 刘凯, 潘化平, 姚佳烽. 基于生物阻抗谱成像的生物组织检测方法. 物理学报, 2022, 71(4): 048706. doi: 10.7498/aps.71.20211600
[3]	尹鸿润, 叶明, 吴阳, 刘凯, 潘化平, 姚佳烽. 基于生物阻抗谱成像的生物组织检测方法. 物理学报, 2021, (): . doi: 10.7498/aps.70.20211600
[4]	谢实梦, 黄林, 王雪, 迟子惠, 汤永辉, 郑铸, 蒋华北. 基于镂空阵列探头的反射式光声/热声双模态组织成像. 物理学报, 2021, 70(10): 100701. doi: 10.7498/aps.70.20202012
[5]	汤永辉, 郑铸, 谢实梦, 黄林, 蒋华北. 基于多路放大器加法电路噪声抑制的热声成像技术. 物理学报, 2020, 69(24): 240701. doi: 10.7498/aps.69.20201036
[6]	周天益. 基于随机场照射的最优微波成像. 物理学报, 2019, 68(5): 055201. doi: 10.7498/aps.68.20182122
[7]	姜海峰. 超稳光生微波源研究进展. 物理学报, 2018, 67(16): 160602. doi: 10.7498/aps.67.20180751
[8]	闫孝鲁, 张晓萍, 李阳梅. X波段新型低阻抗高功率微波源的模拟研究. 物理学报, 2016, 65(13): 138402. doi: 10.7498/aps.65.138402
[9]	张宇, 唐志列, 吴泳波, 束刚. 基于声透镜的三维光声成像技术. 物理学报, 2015, 64(24): 240701. doi: 10.7498/aps.64.240701
[10]	杨华斌, 仝丽, 朱逸伦. 先进微波成像诊断技术中高通滤波板的优化设计. 物理学报, 2015, 64(16): 165202. doi: 10.7498/aps.64.165202
[11]	杜劲松, 高扬, 毕欣, 齐伟智, 黄林, 荣健. S波段微波热致超声成像系统研究. 物理学报, 2015, 64(3): 034301. doi: 10.7498/aps.64.034301
[12]	毕欣, 黄林, 杜劲松, 齐伟智, 高扬, 荣健, 蒋华北. 脉冲微波辐射场空间分布的热声成像研究. 物理学报, 2015, 64(1): 014301. doi: 10.7498/aps.64.014301
[13]	刘西川, 高太长, 刘磊, 翟东力. 基于粒子成像测速技术的雨滴微物理特性研究. 物理学报, 2014, 63(2): 029203. doi: 10.7498/aps.63.029203
[14]	肖夏, 宋航, 王梁, 王宗杰, 路红. 早期乳腺肿瘤的超宽带微波稳健波束形成成像检测系统. 物理学报, 2014, 63(19): 194102. doi: 10.7498/aps.63.194102
[15]	丁亮, 刘培国, 何建国, Joe LoVetri. 一种金属腔体中微波断层成像的最优分层非均一背景. 物理学报, 2014, 63(18): 184102. doi: 10.7498/aps.63.184102
[16]	丁亮, 刘培国, 何建国, Amer Zakaria, Joe LoVetri. 金属圆柱腔体中使用非均一背景增强微波断层成像. 物理学报, 2014, 63(4): 044102. doi: 10.7498/aps.63.044102
[17]	陈再高, 王建国, 王玥, 乔海亮, 郭伟杰, 张殿辉. 基于粒子模拟和并行遗传算法的高功率微波源优化设计. 物理学报, 2013, 62(16): 168402. doi: 10.7498/aps.62.168402
[18]	曾志平, 谢文明, 张建英, 李莉, 陈树强, 李志芳, 李晖. 基于聚焦光声层析技术的甲状腺离体组织成像. 物理学报, 2012, 61(9): 097801. doi: 10.7498/aps.61.097801
[19]	刘广东, 张业荣. 乳腺癌检测的三维微波热声成像技术. 物理学报, 2011, 60(7): 074303. doi: 10.7498/aps.60.074303
[20]	张航. 基于δ声波场的生物组织光学断层成像研究. 物理学报, 2004, 53(8): 2515-2519. doi: 10.7498/aps.53.2515

计量

文章访问数: 5211
PDF下载量: 125
被引次数: 0

姓名
邮箱
手机号码
标题
留言内容
验证码

搜索

留言板