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基于聚焦光声层析技术的甲状腺离体组织成像

曾志平 谢文明 张建英 李莉 陈树强 李志芳 李晖

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基于聚焦光声层析技术的甲状腺离体组织成像

曾志平, 谢文明, 张建英, 李莉, 陈树强, 李志芳, 李晖

Imaging of human thyroid in vitro using focused photoacoustic tomography

Zeng Zhi-Ping, Xie Wen-Ming, Zhang Jian-Ying, Li Li, Chen Shu-Qiang, Li Zhi-Fang, Li Hui
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  • 对人体甲状腺内的病变组织进行定位和成像对于准确诊断和有效治疗甲状腺疾病是至关重要的. 本文评估了利用光声层析技术对离体甲状腺组织进行成像的可行性, 并利用基于30 MHz超声换能器的聚焦光声成像系统对甲状腺进行扫描成像. 实验中成像系统的横向分辨率和纵向分辨率分别达到了350 upm和74 upm. 分别对正常离体甲状腺组织和模拟病变甲状腺组织进行光声成像. 实验结果表明, 本成像系统能够有效区分和鉴别正常甲状腺组织和病变组织. 此项技术有望进一步提高甲状腺疾病诊断的准确率, 以便更为有效地指导疾病的治疗, 具有潜在的临床应用前景.
    Locating and imaging the specific pathological lesions in human thyroid are pretty helpful for reliable diagnosis and effective treatment of thyroid nodules. In this paper, we evaluate the feasibility of photoacoustic tomography (PAT) for imaging thyroid tissue in vitro. Imaging is performed based on an imaging system with a 30 MHz focused transducer. In the experiment, 350 upm transverse resolution and 74 upm axial resolution are achieved. A normal thyroid tissue and the tissue with a mimic lesion embedded are imaged in vitro, Separately. As a result, the localization and the imaging of mimic pathological lesion in human thyroid tissue are realized. We demonstrate that our imaging system is able to detect the lesion from normal thyroid tissue successfully. This technique is expected to be a potential clinical tool for increasing diagnostic accuracy and performing more effective treatment of thyroid diseases.
    • 基金项目: 国家自然科学基金(批准号: 61178089), 高等学校博士学科点专项科研基金(批准号: 200803940001), 教育部新世纪优秀人才计划(批准号: NCET-04-0615)和福建省自然科学基金(批准号: 2009J01137)资助的课题.
    • Funds: Project supported by the National Natural Science Foundation of China (Grant No. 61178089), the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No. 200803940001), the Program for New Century Excellent Talents in University of Ministry of Education of China (Grant No.NCET-04-0615), and the Natural Science Foundation of Fujian Province, China (Grant No. 2009J01137).
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    [2]

    Li C, Wang L V 2009 Phys. Med. Biol. 54 59

    [3]

    Wang L V 2008Med. Phys. 35 5758

    [4]

    Shi W, Kerr S, Utkin I, Ranasinghesagara J, Pan L, Godwal Y, Zemp R J, Fedosejevs R 2010 J. Biomed. Opt. 15 056017

    [5]

    Sheaff C, Lau N, Patel H, Huang S W, Ashkenazi S 2009 Engineering in Medicine and Biology SocietyMinneapolis, USA, September 3--6, 2009 p1983

    [6]

    Fang H, Maslov K, Wang L V 2007 Phys. Rev. Lett. 99 184501

    [7]

    Fang H, Wang L V 2009 Opt. Lett. 34 671

    [8]

    Zhang C, Maslov K, Wang L V 2010 Opt. Lett. 35 3195

    [9]

    Treeby B E, Cox B T 2010 J. Biomed. Opt. 15 021314

    [10]

    Fronheiser M P, Ermilov S A, Brecht H P, Conjusteau A, Su R, Mehta K, Oraevsky A A 2010 J. Biomed. Opt. 15 021305

    [11]

    Wang X, Roberts W W, Carson P L, Wood, D P, Fowlkes J B 2010 Biomed. Opt. Express. 1 1117

    [12]

    Hu J, Yu M, Ye F, Xing D 2011 J. Biomed. Opt. 16 020503

    [13]

    Xu X H, Li H 2008 Acta. Phys. Sin. 57 4623 (in Chinese) [徐晓辉, 李晖 2008 物理学报 57 4623]

    [14]

    Xie W M, Li H, Li Z F, Zhang J Y, Zeng Z P 2010 Proc. SPIE 7850 785004

    [15]

    Zhou C, Wang Y, Aguirre A D, Tsai T H, Cohen D W, Connolly J L, Fujimoto J G 2010 J. Biomed. Opt. 15 016001

    [16]

    Ku G, Maslov K, Li L, Wang L V 2010 J. Biomed. Opt. 15 021302

  • [1]

    Bell A G 1880 Am. J. Sci. 20 305

    [2]

    Li C, Wang L V 2009 Phys. Med. Biol. 54 59

    [3]

    Wang L V 2008Med. Phys. 35 5758

    [4]

    Shi W, Kerr S, Utkin I, Ranasinghesagara J, Pan L, Godwal Y, Zemp R J, Fedosejevs R 2010 J. Biomed. Opt. 15 056017

    [5]

    Sheaff C, Lau N, Patel H, Huang S W, Ashkenazi S 2009 Engineering in Medicine and Biology SocietyMinneapolis, USA, September 3--6, 2009 p1983

    [6]

    Fang H, Maslov K, Wang L V 2007 Phys. Rev. Lett. 99 184501

    [7]

    Fang H, Wang L V 2009 Opt. Lett. 34 671

    [8]

    Zhang C, Maslov K, Wang L V 2010 Opt. Lett. 35 3195

    [9]

    Treeby B E, Cox B T 2010 J. Biomed. Opt. 15 021314

    [10]

    Fronheiser M P, Ermilov S A, Brecht H P, Conjusteau A, Su R, Mehta K, Oraevsky A A 2010 J. Biomed. Opt. 15 021305

    [11]

    Wang X, Roberts W W, Carson P L, Wood, D P, Fowlkes J B 2010 Biomed. Opt. Express. 1 1117

    [12]

    Hu J, Yu M, Ye F, Xing D 2011 J. Biomed. Opt. 16 020503

    [13]

    Xu X H, Li H 2008 Acta. Phys. Sin. 57 4623 (in Chinese) [徐晓辉, 李晖 2008 物理学报 57 4623]

    [14]

    Xie W M, Li H, Li Z F, Zhang J Y, Zeng Z P 2010 Proc. SPIE 7850 785004

    [15]

    Zhou C, Wang Y, Aguirre A D, Tsai T H, Cohen D W, Connolly J L, Fujimoto J G 2010 J. Biomed. Opt. 15 016001

    [16]

    Ku G, Maslov K, Li L, Wang L V 2010 J. Biomed. Opt. 15 021302

计量
  • 文章访问数:  3033
  • PDF下载量:  622
  • 被引次数: 0
出版历程
  • 收稿日期:  2011-06-06
  • 修回日期:  2012-05-10
  • 刊出日期:  2012-05-05

基于聚焦光声层析技术的甲状腺离体组织成像

  • 1. 医学光电科学与技术教育部重点实验室, 福建省光子技术重点实验室, 福建师范大学物理与光电信息科技学院, 福州 350007;
  • 2. 福建医科大学附属第一医院, 福州 350007
    基金项目: 国家自然科学基金(批准号: 61178089), 高等学校博士学科点专项科研基金(批准号: 200803940001), 教育部新世纪优秀人才计划(批准号: NCET-04-0615)和福建省自然科学基金(批准号: 2009J01137)资助的课题.

摘要: 对人体甲状腺内的病变组织进行定位和成像对于准确诊断和有效治疗甲状腺疾病是至关重要的. 本文评估了利用光声层析技术对离体甲状腺组织进行成像的可行性, 并利用基于30 MHz超声换能器的聚焦光声成像系统对甲状腺进行扫描成像. 实验中成像系统的横向分辨率和纵向分辨率分别达到了350 upm和74 upm. 分别对正常离体甲状腺组织和模拟病变甲状腺组织进行光声成像. 实验结果表明, 本成像系统能够有效区分和鉴别正常甲状腺组织和病变组织. 此项技术有望进一步提高甲状腺疾病诊断的准确率, 以便更为有效地指导疾病的治疗, 具有潜在的临床应用前景.

English Abstract

参考文献 (16)

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