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制备了表面带阴/阳离子的多孔二氧化硅纳米颗粒, 通过QCM-D研究了颗粒在不同pH值环境下与磷脂膜的非特异性吸附情况. 结果表明, NH2-MSN 在48的pH值范围内与磷脂膜相互吸引, 而COOH-MSN由于与磷脂膜的电性始终保持一致而无法发生吸附现象. 本研究能够帮助理解和预测纳米颗粒与细胞膜间的相互作用, 为药物输运提供载体, 有助于多孔二氧化硅纳米颗粒在药物输运体系中的应用.
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关键词:
- 多孔二氧化硅纳米颗粒 /
- 磷脂膜 /
- 非特异性吸附 /
- QCM-D
[1] Yousaf M Z, Yu J, Hou Y L, Gao S 2013 Chin. Phys. B 22 058702
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[13] Xia T, Kovochich M, Liong M, Zink J I, Nel A E 2008 ACS Nano. 2 85
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[21] Plant A L, Gueguechkeri M, Yap W 1994 Biophys. J. 67 1126
[22] Plant A L 1999 Langmuir 15 5128
[23] Jiang Z Y, Zhang G L, Ma J, Zhu T 2013 Acta Phys. Sin. 62 018701 (in Chinese) [蒋中英, 张国梁, 马晶, 朱涛 2013 物理学报 62 018701]
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[25] Kecht J, Schlossbauer A, Bein T 2008 Chem. Mater. 20 7207
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[27] Park C, Oh K, Lee S C, Kim C 2007 Angew. Chem. Int. Ed. 46 1455
[28] Academic A U 1991 Nature 354 120
[29] Diao P, Jiang D L, Cui X L, Gu D P, Tong R T, Zhong B 1999 Bioelectrochem. Bioenerg. 48 469
[30] Ding L, Li J H, Dong S J, Wang E K 1996 J. Electroanal. Chem. 416 105
[31] Tu C K, Chen K, Tian W D, Ma Y Q 2013 Macromol. Rapid Comm. 34 1237
[32] Ding H M, Ma Y Q 2012 Biomaterials 33 5798
-
[1] Yousaf M Z, Yu J, Hou Y L, Gao S 2013 Chin. Phys. B 22 058702
[2] Liu J W, Jiang X M, Ashley C, Brinker C J 2009 J. Am. Chem. Soc. 131 7567
[3] Giri S, Trewyn B G, Stellmaker M P, Lin V S Y 2005 Angew. Chem. Int. Ed. 44 5038
[4] Hong C Y, Li X, Pan C Y 2008 J. Phys. Chem. C 112 15320
[5] Liu R, Zhang Y, Zhao X, Agarwal A, Mueller L J, Feng P Y 2010 J. Am. Chem. Soc. 132 1500
[6] Ashley C E, Carnes E C, Phillips G K, Padilla D, Durfee P N, Brown P A, Hanna T N, Liu J W, Phillips B, Carter M B, Carroll N J, Jiang X M, Dunphy D R, Willman C L, Petsev D N, Evans D G, Parikh A N, Chackerian B, Wharton W, Peabody D S, Brinker C J 2011 Nature Materials 10 389
[7] Rosenholm J M, Peuhu E, Eriksson J E, Sahlgren C, Lindén M 2009 Nano Lett. 9 3308
[8] Liong M, Lu J, Kovochich M, Xia T, Ruehm S G, Nel A E, Tamanoi F, Zink J I 2008 ACS Nano. 2 889
[9] Lei J M, L L, Liu L, Xu X L 2011 Acta Phys. Sin. 60 017501 (in Chinese) [雷洁梅, 吕柳, 刘玲, 许小亮 2011 物理学报 60 017501]
[10] Kirchner C, Liedl T, Kudera S, Pellegrino T, Muñoz-Javier A, Gaub H E, Stölzle S, Fertig N, Parak W J 2005 Nano Lett. 5 2331
[11] Cho E C, Xie J, Wurm P A, Xia Y 2009 Nano Lett. 9 1080
[12] Arvizo R R, Miranda O R, Thompson M A, Pabelick C M, Bhattacharya R, Robertson J D, Rotello V M, Prakash Y S, Mukherjee P 2010 Nano Lett. 10 2543
[13] Xia T, Kovochich M, Liong M, Zink J I, Nel A E 2008 ACS Nano. 2 85
[14] Wilhelm C, Billotey C, Roger J, Pons J N, Bacri J C, Gazeau F 2003 Biomaterials 24 1001
[15] Ryman-Rasmussen J P, Riviere J E, Monteiro-Riviere N A 2007 Nano Lett. 7 1344
[16] Zhang X F, Yang S H 2011 Langmuir 27 2528
[17] Rodahl M, Höök F, Fredriksson C, Keller C A, Krozer A, Brzezinski P, Voinova M, Kasemo B 1997 Faraday Discuss 107 229
[18] Voinova M V, Jonson M, Kasemo B 2002 Biosensors and Bioelectronics 17 835
[19] Richter R, Mukhopadhyay A, Brisson A 2003 Biophys. J 85 3035
[20] Lu N Y, Yang K, Yuan B, Ma Y Q 2012 J. Phys. Chem. B 116 9432
[21] Plant A L, Gueguechkeri M, Yap W 1994 Biophys. J. 67 1126
[22] Plant A L 1999 Langmuir 15 5128
[23] Jiang Z Y, Zhang G L, Ma J, Zhu T 2013 Acta Phys. Sin. 62 018701 (in Chinese) [蒋中英, 张国梁, 马晶, 朱涛 2013 物理学报 62 018701]
[24] Möller K, Kobler J, Bein T 2007 Adv. Funct. Mater. 17 605
[25] Kecht J, Schlossbauer A, Bein T 2008 Chem. Mater. 20 7207
[26] Cauda V, Engelke H, Sauer A, Arcizet D, Bräuchle C, Rädler J, Bein T 2010 Nano Lett. 10 2484
[27] Park C, Oh K, Lee S C, Kim C 2007 Angew. Chem. Int. Ed. 46 1455
[28] Academic A U 1991 Nature 354 120
[29] Diao P, Jiang D L, Cui X L, Gu D P, Tong R T, Zhong B 1999 Bioelectrochem. Bioenerg. 48 469
[30] Ding L, Li J H, Dong S J, Wang E K 1996 J. Electroanal. Chem. 416 105
[31] Tu C K, Chen K, Tian W D, Ma Y Q 2013 Macromol. Rapid Comm. 34 1237
[32] Ding H M, Ma Y Q 2012 Biomaterials 33 5798
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