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通过对基于空间相干源和具有分析光栅功能的X射线转换屏的微分干涉X射线相位衬度成像 系统的理论分析, 利用线发射体阵列结构阳极X射线管和光助电化学刻蚀技术 研制的相位光栅和具有分析光栅功能的X射线转换屏, 组建了一种无吸收光栅的X射线微分干涉相衬成像系统. 在此系统上开展了生物样品的实验研究, 获得了较传统吸收成像更为清晰和更多样品结构信息的相位衬度图像. 从而试验验证了该系统方案设计的可行性, 为X射线相衬成像技术从实验室走向临床应用提供了有效途径.
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关键词:
- X射线相衬成像 /
- 阵列结构阳极 /
- 相位光栅 /
- 具有分析光栅功能的转换屏
According to the theoretical analysis of X-ray differential phase-contrast imaging system based on one-dimensional spatial-coherence X-ray source with multi-line structured anode, a scintillator functioning as an absorption grating, and a phase grating fabricated by photo-assisted electrochemical etching technique developed by us, we construct a non-absorption grating X-ray differential phase-contrast imaging system, conduct the experiments on some biological samples prepared with the above system, and finally obtain some phase-contrast images with more structural information than the ones obtained by conventional X-ray absorption method. Consequently, out system can be considered as a feasible imaging system and can have potential applications in hospitals and laboratories.[1] Momose A 1995 Nucl. Instrum. Meth. A 352 622
[2] Ingal V N, Beliaevskaya E A 1995 J. Phys. D: Appl. Phys. 28 2314
[3] Snigirev A, Snigireva I 1995 Rev. Sci. Instrum. 66 5486
[4] Wilkins S W, Gureyev T E, Gao D, Pogany A, Stevenson A W 1996 Nature 384 335
[5] Pfeiffer F, Weitkamp T, Bunk O, David C 2006 Nature Phys. 2 258
[6] Rutishauser S, Zanette I, Donath T, Sahlholm A, Linnros J, David C 2011 Appl. Phys. Lett. 98 171107
[7] Niu H B, Guo J C, Wang K G, Yang Q L 2006 China Patent 200610062487.1
[8] Lei Y H, Liu X, Guo J C, Zhao Z G, Niu H B 2011 Chin. Phys. B 20 042901
[9] Engelhardt M, Baumann J, Schuster M, Kottler C, Pfeiffer F, Bunk O, David C 2007 Appl. Phys. Lett. 90 224101
[10] Liu X 2007 Ph. D. Dissertation (Wuhan: Huazhong University of Science and Technology) (in Chinese) [刘鑫 2007 博士学位论文 (武汉:华中科技大学)]
[11] Liu X, Lei Y H, Zhao Z G, Guo J C, Niu H B 2010 Acta Phys. Sin. 59 6927 (in Chinese) [刘鑫, 雷耀虎, 赵志刚, 郭金川, 牛憨笨 2010 物理学报 59 6927]
[12] Du Y, Liu X, Lei Y H, Guo J C, Niu H B 2011 Opt. Express 19 22669
[13] Liu X, Guo J C, Niu H B 2010 Chin. Phys. B 19 070701
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[1] Momose A 1995 Nucl. Instrum. Meth. A 352 622
[2] Ingal V N, Beliaevskaya E A 1995 J. Phys. D: Appl. Phys. 28 2314
[3] Snigirev A, Snigireva I 1995 Rev. Sci. Instrum. 66 5486
[4] Wilkins S W, Gureyev T E, Gao D, Pogany A, Stevenson A W 1996 Nature 384 335
[5] Pfeiffer F, Weitkamp T, Bunk O, David C 2006 Nature Phys. 2 258
[6] Rutishauser S, Zanette I, Donath T, Sahlholm A, Linnros J, David C 2011 Appl. Phys. Lett. 98 171107
[7] Niu H B, Guo J C, Wang K G, Yang Q L 2006 China Patent 200610062487.1
[8] Lei Y H, Liu X, Guo J C, Zhao Z G, Niu H B 2011 Chin. Phys. B 20 042901
[9] Engelhardt M, Baumann J, Schuster M, Kottler C, Pfeiffer F, Bunk O, David C 2007 Appl. Phys. Lett. 90 224101
[10] Liu X 2007 Ph. D. Dissertation (Wuhan: Huazhong University of Science and Technology) (in Chinese) [刘鑫 2007 博士学位论文 (武汉:华中科技大学)]
[11] Liu X, Lei Y H, Zhao Z G, Guo J C, Niu H B 2010 Acta Phys. Sin. 59 6927 (in Chinese) [刘鑫, 雷耀虎, 赵志刚, 郭金川, 牛憨笨 2010 物理学报 59 6927]
[12] Du Y, Liu X, Lei Y H, Guo J C, Niu H B 2011 Opt. Express 19 22669
[13] Liu X, Guo J C, Niu H B 2010 Chin. Phys. B 19 070701
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