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少节点基因调控网络的控制

叶纬明 吕彬彬 赵琛 狄增如

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少节点基因调控网络的控制

叶纬明, 吕彬彬, 赵琛, 狄增如

Control of few node genetic regulatory networks

Ye Wei-Ming, Lü Bin-Bin, Zhao Chen, Di Zeng-Ru
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  • 近年来, 自组织振荡网络受到越来越多科学家的关注, 对生物体的生长、 发育起调控作用的基因调控网络即是其中的一种. 本文研究了少节点基因调控网络的控制问题. 运用多相位超前驱动方法对该种网络进行调控, 可以有效地提高对网络的控制效率. 通过数值模拟, 发现对于少节点基因调控网络, 当系统参数确定时, 网络的有效控制率可以达到95%以上(10节点网络); 当系统参数不确定时, 控制的效率也非常高.
    Recently, self-organized oscillation networks have aroused great interest in diverse natural and social fields. Genetic regulatory networks are one of the most typical examples of this kind. They control the growth and develop of organism. We investigate the control of few node genetic regulatory networks. We use a method of multiple phase advanced driving to control the networks, which can improve the control efficiency. The numerical simulation, results show that for the network in which system parameter is fixed, the control efficiency will reach 95% (for 10-node network), and the method will also applicable for the network in which system parameter is unfixed.
    • 基金项目: 国家自然科学基金(批准号: 11174034)资助的课题.
    • Funds: Project supported by the National Natural Science Foundation of China (Grant No. 11174034).
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    Li C, Chen L, Aihara L S, Kazuyuki L 2006 IEEE 53 2451

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    Mangan S, Alon U 2001 P. Natl. Acad. Sci. USA 100 11980

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    Setty Y, Mayo A E, Surette M G, Alon U 2003 P. Natl. Acad. Sci. USA 100 7702

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    Ishilara S, Fujimoto K, Shibata T 2005 Genes to Cells 10 1025

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    Wu Y, Zhang X, Yu J, Ouyang Q 2009 PLoS Computational Biology 5 e1000442

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    Ye W, Li P, Huang X, Hu G 2010 Phys. Lett. A 374 4749

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  • [1]

    Tavazoie S, Hughes J D, Campbell M J, Cho G M 1999 Nat. Genet. 22 281

    [2]

    Xu P X, Zhang X, Heaney S, Yoon A, Michelson A M, Maas R L 1999 Development 126 383

    [3]

    Peterson K J, Davidson E H 2000 P. Natl. Acad. Sci. USA 97 4430

    [4]

    Lee T I, Rinaldi N J, Robert F, Odom D T 2002 Science 298 799

    [5]

    Ihmels J, Friedlander G, Bergmann S, Sarig O 2002 Nat. Genet. 31 370

    [6]

    Ma H W, Kumar B, Ditges U, Gunzer F 2004 Nucleic Acids Res. 32 6643

    [7]

    Posfai G, Plunkett G 2006 Science 312 1044

    [8]

    Gilchrist M, Thorsson V, Li B, Rust A G 2006 Nature 441 173

    [9]

    Kurland C G, Collins L J, Penny D 2006 Science 312 1011

    [10]

    Mcadams H H, Srinivasan B, Arkin A P 2004 Nature Rev. Genet. 5 1

    [11]

    Shen-Orr S S, Milo R, Mangan S, Alon U 2002 Nat. Genet. 31 64

    [12]

    Lipshtat A, Purushothaman S P, Lyengar R, Maayan A 2008 Biophysical Journal 94 2566

    [13]

    Kim J R, Yoon Y, Cho K H 2008 Biophysical Journal 94 359

    [14]

    Snoussi E H 1998 J. Biol. Sys. 6 3

    [15]

    Plahte E H, Mestl T, Omholt W S 1995 J. Biol. Sys. 3 409

    [16]

    Goh K G, Kahng B, Cho K H 2008 Biophysical Journal 94 4270

    [17]

    Elowitz M B, Leibler S 2000 Nature 403 335

    [18]

    Nochomovitz Y D, Li H 2006 P. Natl. Acad. Sci. USA 103 4180

    [19]

    Qian Y, Liao X, Huang X, Hu G 2010 Phys. Rev. E 81 036101

    [20]

    Liao X, Hu G 2011 Front. Phys. 6 124

    [21]

    Ye W, Huang X, Li P, Hu G 2010 Phys. Lett. A 374 2521

    [22]

    Li C, Chen L, Aihara L S, Kazuyuki L 2006 IEEE 53 2451

    [23]

    Mangan S, Alon U 2001 P. Natl. Acad. Sci. USA 100 11980

    [24]

    Setty Y, Mayo A E, Surette M G, Alon U 2003 P. Natl. Acad. Sci. USA 100 7702

    [25]

    Ishilara S, Fujimoto K, Shibata T 2005 Genes to Cells 10 1025

    [26]

    Wu Y, Zhang X, Yu J, Ouyang Q 2009 PLoS Computational Biology 5 e1000442

    [27]

    Ye W, Li P, Huang X, Hu G 2010 Phys. Lett. A 374 4749

    [28]

    Ye W, Zhang Z, L B, Di Z, Hu G 2012 Chin. Phys. B 21 060203

计量
  • 文章访问数:  5720
  • PDF下载量:  743
  • 被引次数: 0
出版历程
  • 收稿日期:  2012-07-18
  • 修回日期:  2012-07-31
  • 刊出日期:  2013-01-05

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