观测包膜微泡在超声场中的动力学行为

梁金福; 陈伟中; 邵纬航; 周超; 杜联芳; 金利芳

doi:10.7498/aps.62.084708

摘要

运用长距离显微成像系统与锁相积分拍摄技术相结合的方法, 拍到了单个造影剂微泡在两种不同频率和不同声压下的周期性振动图像. 根据这些图像得到了微泡直径的实验数据, 并分别用Hoff模型和Rayleigh-Plesset模型对数据进行拟合, 并对数据进行了频谱分析. 结果表明:Hoff模型对实验数据的拟合结果优于Rayleigh-Plesset模型的拟合结果; 二次谐波的相对强度随着声压幅度的升高而增大.

关键词:

Abstract

Using a long-distance microscope imaging system and a lock-in phase integrate technique, optical measurements demonstrate that the evolutional behaviors of a phospholipid-shelled micro-bubble, a kind of ultrasound contrast agent, under two ultrasound frequencies and different pressures. Dozens of frames of an oscillating microbubble for one acoustic cycle are captured. The experimental data of micro-bubble diameter are fit by the numerical calculations of the Hoff model and the Rayleigh-Plesset model, respectively. The results show the good agreement between experimental data and the theoretical calculation in the Hoff model. In addition, the spectral analysis based on the experimental data indicates that the relative intensity of the second harmonic increases with the driving pressure amplitude.

Keywords:

作者及机构信息

1.
南京大学声学研究所, 近代声学国家重点实验室, 南京 210093;

2.
上海第一人民医院, 超声部, 上海 200089

基金项目: 国家自然科学基金(批准号:10974095, 11174145)资助的课题.

Authors and contacts

1.
The Key Laboratory of Modern Acoustics, Ministry of Education, Institution of Acoustics, Nanjing University, Nanjing 210093, China;

2.
Department of Ultrasound, Shanghai First People's Hospital, Shanghai 200089, China

Funds: Project supported the National Natural Science Foundation of China (Grant Nos. 10974095, 11174145).

参考文献

[1]	Goldberg B B, Raichlen J S, Forsberg F 2001 Ultrasound Contrast Agents-Basic Principles and Clinical Applications (2nd Ed.) (London:Martin Dunitz) p25
[2]	Shankar P M, Krishna P D, Newhouse V L 1998 Ultrasound Med. Biol. 24 395
[3]	Bloch S H, Dayton P A, Ferrara K W 2004 IEEE Eng. Med. Biol. Mag. 23 18
[4]	Robertson V J, Baker K G 2001 Phys. Ther. 81 1339
[5]	Church C C 1995 J. Acoust. Soc. Am. 97 1510
[6]	Hoff L, Sontum P C, Hovem J M 2000 J. Acoust. Soc. Am. 107 2272
[7]	Marmottant P, van der Meer S, Emmer M, Versluis M, de Jong N, Hilgenfeldt S, Lohse D 2005 J. Acoust. Soc. Am. 118 3499
[8]	de Jong N, Frinking P J A, Bouakaz A, Goorden M, Schourmans T, Jingping X, Mastik F 2000 Ultrasound Med. Biol. 26 487
[9]	Chomas J E, Dayton P, May D, Ferrara K 2001 J. Biomed. Opt. 6 41
[10]	Postema M, Bouakaaz A, Chin C T, de Jong N 2003 IEEE Trans. Ultrason. Ferroelect. Freq. Contr. 50 523
[11]	Chen H, Kreider W, Brayman A A, Bailey M R, Matula T J 2011 Phys. Rev. Lett. 106 034301
[12]	Wolfrum B, Mettin R, Lauterborn W 2002 Appl. Phys. Lett. 81 5060
[13]	Liu Y N, Chen W Z, Huang W, Gao X X 2005 Chin. Sci. Bull. 50 2458 (in Chinese) [刘亚楠, 陈伟中, 黄威, 高娴娴 2005 科学通报 50 2458]
[14]	Huang W, Chen W Z, Liu Y N, Gao X X 2006 Ultrasonics 44 e407
[15]	Matula T J 2000 Ultrasonics 38 559
[16]	Keller J B, Miksis M 1980 J. Acoust. Soc. Am. 68 628

施引文献

[1]	Goldberg B B, Raichlen J S, Forsberg F 2001 Ultrasound Contrast Agents-Basic Principles and Clinical Applications (2nd Ed.) (London:Martin Dunitz) p25
[2]	Shankar P M, Krishna P D, Newhouse V L 1998 Ultrasound Med. Biol. 24 395
[3]	Bloch S H, Dayton P A, Ferrara K W 2004 IEEE Eng. Med. Biol. Mag. 23 18
[4]	Robertson V J, Baker K G 2001 Phys. Ther. 81 1339
[5]	Church C C 1995 J. Acoust. Soc. Am. 97 1510
[6]	Hoff L, Sontum P C, Hovem J M 2000 J. Acoust. Soc. Am. 107 2272
[7]	Marmottant P, van der Meer S, Emmer M, Versluis M, de Jong N, Hilgenfeldt S, Lohse D 2005 J. Acoust. Soc. Am. 118 3499
[8]	de Jong N, Frinking P J A, Bouakaz A, Goorden M, Schourmans T, Jingping X, Mastik F 2000 Ultrasound Med. Biol. 26 487
[9]	Chomas J E, Dayton P, May D, Ferrara K 2001 J. Biomed. Opt. 6 41
[10]	Postema M, Bouakaaz A, Chin C T, de Jong N 2003 IEEE Trans. Ultrason. Ferroelect. Freq. Contr. 50 523
[11]	Chen H, Kreider W, Brayman A A, Bailey M R, Matula T J 2011 Phys. Rev. Lett. 106 034301
[12]	Wolfrum B, Mettin R, Lauterborn W 2002 Appl. Phys. Lett. 81 5060
[13]	Liu Y N, Chen W Z, Huang W, Gao X X 2005 Chin. Sci. Bull. 50 2458 (in Chinese) [刘亚楠, 陈伟中, 黄威, 高娴娴 2005 科学通报 50 2458]
[14]	Huang W, Chen W Z, Liu Y N, Gao X X 2006 Ultrasonics 44 e407
[15]	Matula T J 2000 Ultrasonics 38 559
[16]	Keller J B, Miksis M 1980 J. Acoust. Soc. Am. 68 628

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