The degree of freedom of orbital angular momentum of light has been used as a new information carrier in optical holographic information processing technology. However, current research on orbital angular momentum holography mainly focuses on two-dimensional orbital angular momentum holography, where the reconstructed two-dimensional holographic image is located in a certain plane in three-dimensional space. How to further implement three-dimensional spatial orbital angular momentum holographic technology and use it to increase the information capacity of holographic communication is still a blank. Here, we implement three-dimensional spatial orbital angular momentum holographic technology based on the degrees of freedom of orbital angular momentum and the positional degrees of freedom of reconstructed two-dimensional images in three-dimensional space. In other words, in the three-dimensional spatial orbital angular momentum holography, the acquisition of the target object image requires not only the correct orbital angular momentum state used for decoding, but also the correct spatial position where the object’s image is detected. In addition, we further investigate the three-dimensional spatial orbit angular momentum holographic multiplexing technology and point out that this multiplexing technology can be used for information encryption. Compared with traditional two-dimensional orbital angular momentum holography, three-dimensional spatial orbital angular momentum holography uses an additional degree of freedom. Therefore, the encryption scheme based on three-dimensional spatial orbital angular momentum holographic technology can further improve the security level of information. Our simulation results and experimental results have verified the feasibility of three-dimensional spatial orbit angular momentum holographic technology and three-dimensional spatial orbit angular momentum holographic encryption technology.